Introduction
Goblet Cells: Differentiation and Biology
Mucins: Main Goblet Cell Product
Structure and Classification of Mucins
Biosynthesis and Secretion of Mucins
Regulation of Mucin Synthesis
Intestinal Mucus Layer and Commensal Microbes
Intestinal Mucus Layer
Mucus layer | Mean mucus thickness ± SE, μm
| |||||
---|---|---|---|---|---|---|
Stomach | Small intestine | Colon | ||||
Corpus | Antrum | Duodenum | Jejunum | Ileum | 1–2 cm distal to cecum | |
Loosely adherent mucus layer | 109 ± 12 | 120 ± 38 | 154 ± 39 | 108 ± 5 | 447 ± 47 | 714 ± 109 |
Firmly adherent mucus layer | 80 ± 5 | 154 ± 16 | 16 ± 3 | 15 ± 2 | 29 ± 8 | 116 ± 51 |
Total mucus layer | 189 ± 11 | 274 ± 41 | 170 ± 38 | 123 ± 4 | 476 ± 47 | 830 ± 110 |
Intestinal Mucus Barrier, Microbes, and Probiotics
Other Goblet Cell Products
Intestinal Trefoil Factor
Study | Name | Other names | Peptide | Functions |
---|---|---|---|---|
MUC2 | Goblet cell mucin Secretory mucin | Monomer (2.5 MDa) | Major component of mucus layers (protective barrier, lubrication, elimination). Binding sites and nutrient sources of microbes. | |
Oigomer (100 MDa) | ||||
MUC1/MUC3/MUC17 | Membrane-bound mucin | Variable sizes 200– > 2000 kDa | Cell surface protective barrier, extracellular portions cleaved or shed and bioactive for epithelial restitution | |
TFF3 | Intestinal trefoil factor (ITF) | Monomer (6.6 kDa) | Epithelial restitution and wound healing. Facilitates cell migration. Blocks apoptosis. Increases mucus viscosity and structural integrity of mucus layers. | |
Dimer (13 kDa) | ||||
RELMβ | Resistin-like molecule β, F1ZZ2 | Monomer (12.5 kDa) | Upregulates MUC2 expression/secretion. Induces goblet cell hyperplasia. Functions as Th2 cytokine-induced immune-effector molecule in resistance to intestinal nematode infection. Inhibits chemotaxis of nematode by direct binding to their chemosensory apparatus. | |
Dimer (25 kDa) | ||||
Fcgbp | Fc-γ binding protein | Full-length protein | Binds 1gG antibodies. Stabilization and cross-linking of the MUC2 mucin networks of the inner firm mucus layer. | |
IgG Fc binding protein | (596 kDa) |