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Current Gastroenterology Reports
Erschienen in: Current Gastroenterology Reports 8/2021

01.08.2021 | Pediatric Gastroenterology (S Orenstein and S Khan, Section Editors)

Overview of Albumin Physiology and its Role in Pediatric Diseases

verfasst von: Charles B. Chen, Bilasan Hammo, Jessica Barry, Kadakkal Radhakrishnan

Erschienen in: Current Gastroenterology Reports | Ausgabe 8/2021

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Abstract

Purpose of Review

Albumin plays a critical role in a wide range of disease processes; however, the role of albumin in pediatric patients has not been well described. This article aims to review albumin physiology and kinetics in children, albumin’s impact on pediatric diseases, and the utility of albumin as a predictor of clinical outcome.

Recent Findings

Hypoalbuminemia is seen in a wide range of conditions, including protein-losing enteropathy, hepatic synthetic failure, malnutrition, inflammatory states, and renal disease. While the impact of hypoalbuminemia has been more extensively studied in adult patients, there is a relative paucity of literature in the pediatric population.

Summary

Hypoalbuminemia is a marker of poor outcome in critically ill children and those undergoing a wide range of medical interventions. Albumin infusions may be an effective therapy for fluid resuscitation and for patients with severe hypoalbuminemia.
Literatur
1.
2.
Sethi PK, White CA, Cummings BS, Hines RN, Muralidhara S, Bruckner JV. Ontogeny of plasma proteins, albumin and binding of diazepam, cyclosporine, and deltamethrin. Pediatr Res. 2016;79(3):409–15.PubMedCrossRef
3.
Levitt DG, Levitt MD. Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements. Int J Gen Med. 2016;9:229–55.PubMedPubMedCentralCrossRef
4.
Weaving G, Batstone GF, Jones RG. Age and sex variation in serum albumin concentration: an observational study. Ann Clin Biochem. 2016;53(Pt 1):106–11.PubMedCrossRef
5.
Kanakoudi F, Drossou V, Tzimouli V, Diamanti E, Konstantinidis T, Germenis A, et al. Serum concentrations of 10 acute-phase proteins in healthy term and preterm infants from birth to age 6 months. Clin Chem. 1995;41(4):605–8.PubMedCrossRef
6.
Lee M, Youn S, Lim BK, Kim JS. Serum albumin concentrations and clinical disorders byGestational ages in preterm babies. Korean Journal of Pediatrics. 2005;48:148–53.
7.
Nicholson JP, Wolmarans MR, Park GR. The role of albumin in critical illness. Br J Anaesth. 2000;85(4):599–610.PubMedCrossRef
8.
Peters TJ. All about Albumin. Biochemistry, Genetics, and Medical Applications. San Diego: Academic Press; 1996. p. 188–250.
9.
Caso G, Feiner J, Mileva I, Bryan LJ, Kelly P, Autio K, et al. Response of albumin synthesis to oral nutrients in young and elderly subjects. Am J Clin Nutr. 2007;85(2):446–51.PubMedCrossRef
10.
Chen Q, Lu M, Monks BR, Birnbaum MJ. Insulin is required to maintain albumin expression by inhibiting Forkhead box O1 protein. J Biol Chem. 2016;291(5):2371–8.PubMedCrossRef
11.
Schnitzer JE, Bravo J. High affinity binding, endocytosis, and degradation of conformationally modified albumins. Potential role of gp30 and gp18 as novel scavenger receptors. J Biol Chem. 1993;268(10):7562–70.PubMedCrossRef
12.
Guthe HJ, Indrebø M, Nedrebø T, Norgård G, Wiig H, Berg A. Interstitial fluid colloid osmotic pressure in healthy children. PLoS One. 2015;10(4):e0122779.PubMedPubMedCentralCrossRef
13.
14.
15.
16.
Neuzil J, Stocker R. Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J Biol Chem. 1994;269(24):16712–9.PubMedCrossRef
17.
Mertens L, Hagler DJ, Sauer U, Somerville J, Gewillig M. Protein-losing enteropathy after the Fontan operation: an international multicenter study. PLE study group. J Thorac Cardiovasc Surg. 1998;115(5):1063–73.PubMedCrossRef
18.
19.
Feldt RH, Driscoll DJ, Offord KP, Cha RH, Perrault J, Schaff HV, et al. Protein-losing enteropathy after the Fontan operation. J Thorac Cardiovasc Surg. 1996;112(3):672–80.PubMedCrossRef
20.
Pundi KN, Johnson JN, Dearani JA, Pundi KN, Li Z, Hinck CA, et al. 40-year follow-up after the Fontan operation: long-term outcomes of 1,052 patients. J Am Coll Cardiol. 2015;66(15):1700–10.PubMedCrossRef
21.
Levitt DG, Levitt MD. Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states. Clin Exp Gastroenterol. 2017;10:147–68.PubMedPubMedCentralCrossRef
22.
Stephen J, Vilboux T, Haberman Y, Pri-Chen H, Pode-Shakked B, Mazaheri S, et al. Congenital protein losing enteropathy: an inborn error of lipid metabolism due to DGAT1 mutations. Eur J Hum Genet. 2016;24(9):1268–73.PubMedPubMedCentralCrossRef
23.
Altinel Acoglu E, Akcaboy M, Melek Oguz M, Kilic M, Zorlu P, Senel S. Hypoalbuminemia and malnutrition associated with Cow's Milk allergy: a case report. Iran Red Crescent Med J. 2016;18(6):e34810.PubMedPubMedCentralCrossRef
24.
Hwang JB, Lee SH, Kang YN, Kim SP, Suh SI, Kam S. Indexes of suspicion of typical cow's milk protein-induced enterocolitis. J Korean Med Sci. 2007;22(6):993–7.PubMedPubMedCentralCrossRef
25.
Yasuda JL, Rufo PA. Protein-losing enteropathy in the setting of severe Iron deficiency Anemia. J Investig Med High Impact Case Rep. 2018;6:2324709618760078.PubMedPubMedCentral
26.
Tracy MS, Yasuda JL, Rufo PA. Protein-losing enteropathy in the setting of Iron deficiency Anemia: a case series. JPGN Reports. 2020;1(2):e009.CrossRef
27.
Eastham EJ. Walker WA effect of cow's milk on the gastrointestinal tract: a persistent dilemma for the pediatrician. Pediatrics. 1977;60(4):477–81.PubMed
28.
Wong CS, Hingorani S, Gillen DL, Sherrard DJ, Watkins SL, Brandt JR, et al. Hypoalbuminemia and risk of death in pediatric patients with end-stage renal disease. Kidney Int. 2002;61(2):630–7.PubMedCrossRef
29.
Honda M, Kamiyama Y, Kawamura K, Kawahara K, Shishido S, Nakai H, et al. Growth, development and nutritional status in Japanese children under 2 years on continuous ambulatory peritoneal dialysis. Pediatr Nephrol. 1995;9(5):543–8.PubMedCrossRef
30.
Roy RR, Islam MR, Jesmin T, Matin A, Islam MR. Prognostic value of biochemical and hematological parameters in children with nephrotic syndrome. J Shaheed Suhrawardy Med Coll. 2013;5(2):95–8.CrossRef
31.
Mishra OP, Abhinay A, Mishra RN, Prasad R, Pohl M. Can we predict relapses in children with idiopathic steroid-sensitive nephrotic syndrome? J Trop Pediatr. 2013;59(5):343–9.PubMedCrossRef
32.
Fagundes ED, Ferreira AR, Roquete ML, Penna FJ, Goulart EM, Figueiredo Filho PP, et al. Clinical and laboratory predictors of esophageal varices in children and adolescents with portal hypertension syndrome. J Pediatr Gastroenterol Nutr. 2008;46:178–83.PubMedCrossRef
33.
Gana JC, Turner D, Roberts EA, Ling SC. Derivation of a clinical prediction rule for the noninvasive diagnosis of varices in children. J Pediatr Gastroenterol Nutr. 2010;50:188–93.PubMedCrossRef
34.
35.
Minchiotti L, Caridi G, Campagnoli M, Lugani F, Galliano M, Kragh-Hansen U. Diagnosis, phenotype, and molecular genetics of congenital Analbuminemia. Front Genet. 2019;10:336.PubMedPubMedCentralCrossRef
36.
Suppressa P, Carbonara C, Lugani F, Campagnoli M, Troiano T, Minchiotti L, et al. Congenital analbuminemia in a patient affected by hypercholesterolemia: a case report. World J Clin Cases. 2019;7(4):466–72.PubMedPubMedCentralCrossRef
37.
Del Ben M, Angelico F, Loffredo L, Violi F. Treatment of a patient with congenital analbuminemia with atorvastatin and albumin infusion. World J Clin Cases. 2013;1(1):44–8.PubMedPubMedCentralCrossRef
38.
Yokoseki A, Ishihara T, Koyama A, Shiga A, Yamada M, Suzuki C, et al. Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminaemia. Brain. 2011;134(Pt 5):1387–99.PubMedCrossRef
39.
Renaud M, Moreira MC, Ben Monga B, Rodriguez D, Debs R, Charles P, et al. Clinical, biomarker, and molecular delineations and genotype-phenotype correlations of Ataxia with oculomotor apraxia type 1. JAMA Neurol. 2018;75(4):495–502.PubMedPubMedCentralCrossRef
40.
JG L. Congenital disorders of N-glycosylation including diseases associated with O- as well as N-glycosylation defects. Pediatr Res 2006;60:643–656.
41.
42.
43.
Lark RK, Williams CL, Stadler D, Simpson SL, Henderson RC, Samson-Fang L, et al. Serum prealbumin and albumin concentrations do not reflect nutritional state in children with cerebral palsy. J Pediatr. 2005;147(5):695–7.PubMedCrossRef
44.
Soeters PB, Wolfe RR, Shenkin A. Hypoalbuminemia: pathogenesis and clinical significance. JPEN J Parenter Enteral Nutr. 2019;43(2):181–93.PubMedCrossRef
45.
De Bandt JP. Understanding the pathophysiology of malnutrition for better treatment. Ann Pharm Fr. 2015;73:332–5.PubMedCrossRef
46.
Gopalan C. Kwashiorkor and marasmus: evolution and distinguishing features. 1968. Natl Med J India. 1992;5:145–51.PubMed
47.
Morlese JF, Forrester T, Badaloo A, Del Rosario M, Frazer M, Jahoor F. Albumin kinetics in edematous and nonedematous protein-energy malnourished children. Am J Clin Nutr. 1996;64(6):952–9.PubMedCrossRef
48.
Narayanan V, Gaudiani JL, Mehler PS. Serum albumin levels may not correlate with weight status in severe anorexia nervosa. Eat Disord. 2009;17(4):322–6.PubMedCrossRef
49.
Winston AP. The clinical biochemistry of anorexia nervosa. Ann Clin Biochem. 2012;49(Pt 2):132–43.PubMedCrossRef
50.
Herzog W, Deter HC, Fiehn W, Petzold E. Medical findings and predictors of long-term physical outcome in anorexia nervosa: a prospective, 12-year follow-up study. Psychol Med. 1997;27(2):269–79.PubMedCrossRef
51.
Don BR, Kaysen G. Serum albumin: relationship to inflammation and nutrition. Semin Dial. 2004;17(6):432–7.PubMedCrossRef
52.
53.
Qian SY, Liu J. Relationship between serum albumin level and prognosis in children with sepsis, severe sepsis or septic shock. Zhonghua Er Ke Za Zhi. 2012;50(3):184–7.PubMed
54.
Tiwari LK, Singhi S, Jayashree M, Baranwal AK, Bansal A. Hypoalbuminemia in critically sick children. Indian J Crit Care Med. 2014;18(9):565–9.PubMedPubMedCentralCrossRef
55.
Kim YS, Sol IS, Kim MJ, Kim SY, Kim JD, Kim YH, et al. Serum albumin as a biomarker of poor prognosis in the pediatric patients in intensive care unit. Korean J Crit Care Med. 2017;32(4):347–55.PubMedPubMedCentralCrossRef
56.
Leite HP, Rodrigues da Silva AV, de Oliveira Iglesias SB, Koch Nogueira PC. Serum albumin is an independent predictor of clinical outcomes in critically ill children. Pediatr Crit Care Med 2016;17(2):e50–e57.
57.
Horowitz IN, Tai K. Hypoalbuminemia in critically ill children. Arch Pediatr Adolesc Med. 2007;161(11):1048–52.PubMedCrossRef
58.
Leite HP, Fisberg M, de Carvalho WB, de Camargo Carvalho AC. Serum albumin and clinical outcome in pediatric cardiac surgery. Nutrition. 2005;21(5):553–8.PubMedCrossRef
59.
Schiller O, Goldshmid O, Mowassi S, Shostak E, Manor O, Amir G, et al. The utility of albumin level as a marker of postoperative course in infants undergoing repair of congenital heart disease. Pediatr Cardiol. 2020;41(5):939–46.PubMedCrossRef
60.
Henry BM, Borasino S, Ortmann L, Figueroa M, Rahman AKMF, Hock KM, et al. Perioperative serum albumin and its influence on clinical outcomes in neonates and infants undergoing cardiac surgery with cardiopulmonary bypass: a multi-Centre retrospective study. Cardiol Young. 2019;29(6):761–7.PubMedCrossRef
61.
Castleberry C, White-Williams C, Naftel D, Tresler MA, Pruitt E, Miyamoto SD, et al. Hypoalbuminemia and poor growth predict worse outcomes in pediatric heart transplant recipients. Pediatr Transplant. 2014;18(3):280–7.PubMedCrossRef
62.
Tancredi DJ, Butani L. Pretransplant serum albumin is an independent predictor of graft failure in pediatric renal transplant recipients. J Pediatr. 2014;164(3):602–6.PubMedCrossRef
63.
Teagarden AM, Skiles JL, Beardsley AL, Hobson MJ, Moser EAS, Renbarger JL, et al. Low serum albumin levels prior to pediatric allogeneic HCT are associated with increased need for critical care interventions and increased 6-month mortality. Pediatr Transplant. 2017;21(6). https://​doi.​org/​10.​1111/​petr.​13016.
64.
Wayman KI, Cox KL, Esquivel CO. Neurodevelopmental outcome of young children with extrahepatic biliary atresia 1 year after liver transplantation. J Pediatr. 1997;131(6):894–8.PubMedCrossRef
65.
Myers RP, Shaheen AA, Faris P, Aspinall AI, Burak KW. Revision of MELD to include serum albumin improves prediction of mortality on the liver transplant waiting list. PLoS One. 2013;8(1):e51926.PubMedPubMedCentralCrossRef
66.
McDiarmid SV, Anand R, Lindblad AS. Principal investigators and institutions of the studies of pediatric liver transplantation (SPLIT) research group. Development of a pediatric end-stage liver disease score to predict poor outcome in children awaiting liver transplantation. Transplantation. 2002;74(2):173–81.PubMedCrossRef
67.
Jiang L, Jiang S, Zhang M, Zheng Z, Ma Y. Albumin versus other fluids for fluid resuscitation in patients with sepsis: a meta-analysis. PLoS One. 2014;9(12):e114666.PubMedPubMedCentralCrossRef
68.
Dingankar AR, Cave DA, Anand V, Sivarajan VB, Nahirniak S, Sheppard C, et al. Albumin 5% versus crystalloids for fluid resuscitation in children after cardiac surgery. Pediatr Crit Care Med. 2018;19(9):846–53.PubMedCrossRef
69.
Romanowski KS, Palmieri TL. Pediatric burn resuscitation: past, present, and future. Burns Trauma. 2017;5(26).
70.
Müller Dittrich MH. Brunow de Carvalho W, lopes Lavado E. evaluation of the "early" use of albumin in children with extensive burns: a randomized controlled trial. Pediatr Crit Care Med. 2016;17(6):e280–6.PubMedCrossRef
71.
Faraklas I, Lam U, Cochran A, Stoddard G, Saffle J. Colloid normalizes resuscitation ratio in pediatric burns. J Burn Care Res. 2011;32(1):91–7.PubMedCrossRef
72.
Greenhalgh DG, Housinger TA, Kagan RJ, Rieman M, James L, Novak S, et al. Maintenance of serum albumin levels in pediatric burn patients: a prospective, randomized trial. J Trauma. 1995;39(1):67–73.PubMedCrossRef
73.
Kapur G, Valentini RP, Imam AA, Mattoo TK. Treatment of severe edema in children with nephrotic syndrome with diuretics alone--a prospective study. Clin J Am Soc Nephrol. 2009;4:907–13.PubMedPubMedCentralCrossRef
74.
Liumbruno GM, Bennardello F, Lattanzio A, Piccoli P, Rossettias G. Italian Society of Transfusion Medicine and Immunohaematology (SIMTI). Recommendations for the use of albumin and immunoglobulins. Blood Transfus. 2009;7(3):216–34.PubMedPubMedCentral
75.
Vincent JL, Wilkes MM, Navickis RJ. Safety of human albumin--serious adverse events reported worldwide in 1998-2000. Br J Anaesth. 2003;91(5):625–30.PubMedCrossRef
76.
Dharmaraj R, Hari P, Bagga A. Randomized cross-over trial comparing albumin and frusemide infusions in nephrotic syndrome. Pediatr Nephrol. 2009;24:775–82.PubMedCrossRef
77.
Yoshimura A, Ideura T, Iwasaki S, Taira T, Koshikawa S. Aggravation of minimal change nephrotic syndrome by administration of human albumin. Clin Nephrol. 1992;37:109–14.PubMed
Metadaten
Titel
Overview of Albumin Physiology and its Role in Pediatric Diseases
verfasst von
Charles B. Chen
Bilasan Hammo
Jessica Barry
Kadakkal Radhakrishnan
Publikationsdatum
01.08.2021
Verlag
Springer US
Erschienen in
Current Gastroenterology Reports / Ausgabe 8/2021
Print ISSN: 1522-8037
Elektronische ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-021-00813-6

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