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Current Hematologic Malignancy Reports

Erschienen in:

01.06.2013 | Acute Leukemias (E Feldman, Section Editor)

Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

verfasst von: A. K. Fielding, G. A. Zakout

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 2/2013

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Abstract

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is characterized by expression of oncogenic fusion product BCR-ABL1, resulting from reciprocal translocation between chromosomes 9 and 22 [t(9;22)(q34;q11.2)]. Previously perceived to confer poor outcome with at least 10 % lower chance of remission than standard-risk ALL. With the advent of targeted BCR-ABL specific tyrosine-kinase inhibitors (TKIs), higher remission rates were achieved, thus allowing more patients to proceed with the definitive treatment modality—allogeneic hematopoietic stem cell transplantation (alloHSCT). Prime challenges to treatment of Ph+ ALL include appropriate integration of TKIs into remission induction chemotherapeutic regimes, appropriate understanding and implementation of BCR-ABL monitoring for guiding therapeutic intervention(s), and minimizing transplant-related toxicities.

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Titel: Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
verfasst von: A. K. Fielding
G. A. Zakout
Publikationsdatum: 01.06.2013
Verlag: Current Science Inc.
Erschienen in: Current Hematologic Malignancy Reports / Ausgabe 2/2013
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-013-0155-4

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

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