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Current Hematologic Malignancy Reports

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01.12.2013 | Myelodysplastic Syndromes (M Sekeres, Section Editor)

There’s Risk, and Then There’s RISK: The Latest Clinical Prognostic Risk Stratification Models in Myelodysplastic Syndromes

verfasst von: Amer M. Zeidan, Rami S. Komrokji

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 4/2013

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Abstract

Myelodysplastic syndromes (MDS) include a diverse group of clonal hematopoietic disorders characterized by progressive cytopenias and propensity for leukemic progression. The biologic heterogeneity that underlies MDS translates clinically in wide variations of clinical outcomes. Several prognostic schemes were developed to predict the natural course of MDS, counsel patients, and allow evidence-based, risk-adaptive implementation of therapeutic strategies. The prognostic schemes divide patients into subgroups with similar prognosis, but the extent to which the prognostic prediction applies to any individual patient is more variable. None of these instruments was designed to predict the clinical benefit in relation to any specific MDS therapy. The prognostic impact of molecular mutations is being more recognized and attempts at incorporating it into the current prognostic schemes are ongoing.

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Titel: There’s Risk, and Then There’s RISK: The Latest Clinical Prognostic Risk Stratification Models in Myelodysplastic Syndromes
verfasst von: Amer M. Zeidan
Rami S. Komrokji
Publikationsdatum: 01.12.2013
Verlag: Springer US
Erschienen in: Current Hematologic Malignancy Reports / Ausgabe 4/2013
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-013-0172-3

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There’s Risk, and Then There’s RISK: The Latest Clinical Prognostic Risk Stratification Models in Myelodysplastic Syndromes

Abstract

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