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Current HIV/AIDS Reports

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01.09.2013 | Metabolic Complications and Comorbidity (JM Kilby, Section Editor)

Solid Organ Transplants in HIV-Infected Patients

verfasst von: Jack Harbell, Norah A. Terrault, Peter Stock

Erschienen in: Current HIV/AIDS Reports | Ausgabe 3/2013

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Abstract

There is a growing need for kidney and liver transplants in persons living with HIV. Fortunately, with the significant advances in antiretroviral therapy and management of opportunistic infections, HIV infection is no longer an absolute contraindication for solid organ transplantation. Data from several large prospective multi-center cohort studies have shown that solid organ transplantation in carefully selected HIV-infected individuals is safe. However, significant challenges have been identified including prevention of acute rejection, management of drug-drug interactions and treatment of recurrent viral hepatitis. This article reviews the selection criteria, outcomes, and special management considerations for HIV-infected patients undergoing liver or kidney transplantation.

Spital A. Should all human immunodeficiency virus-infected patients with end-stage renal disease be excluded from transplantation? The views of U.S. transplant centers. Transplantation. 1998;65:1187–91.PubMedCrossRef

Palella Jr FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338:853–60.PubMedCrossRef

Feinberg MB. Changing the natural history of HIV disease. Lancet. 1996;348:239–46.PubMedCrossRef

Kaplan JE, Hanson D, Dworkin MS, et al. Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy. Clin Infect Dis. 2000;30 Suppl 1:S5–14.PubMedCrossRef

Ockenga J, Tillmann HL, Trautwein C, et al. Hepatitis B and C in HIV-infected patients. Prevalence and prognostic value. J Hepatol. 1997;27:18–24.PubMedCrossRef

Staples Jr CT, Rimland D, Dudas D. Hepatitis C in the HIV (human immunodeficiency virus) Atlanta V.A. (Veterans Affairs Medical Center) Cohort Study (HAVACS): the effect of coinfection on survival. Clin Infect Dis. 1999;29:150–4.PubMedCrossRef

Soto B, Sanchez-Quijano A, Rodrigo L, et al. Human immunodeficiency virus infection modifies the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis. J Hepatol. 1997;26:1–5.PubMedCrossRef

Selik RM, Byers Jr RH, Dworkin MS. Trends in diseases reported on U.S. death certificates that mentioned HIV infection, 1987-1999. J Acquir Immune Defic Syndr. 2002;29:378–87.PubMed

USRDS: the United States Renal Data System. Am J Kidney Dis. 2003;42:1–230.

10.

Tokizawa S, Shimizu N, Hui-Yu L, et al. Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor. Kidney Int. 2000;58:607–17.PubMedCrossRef

11.

Winston JA, Bruggeman LA, Ross MD, et al. Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection. N Engl J Med. 2001;344:1979–84.PubMedCrossRef

12.

Erice A, Rhame FS, Heussner RC, et al. Human immunodeficiency virus infection in patients with solid-organ transplants: report of five cases and review. Rev Infect Dis. 1991;13:537–47.PubMedCrossRef

13.

Trullas JC, Cofan F, Tuset M, et al. Renal transplantation in HIV-infected patients: 2010 update. Kidney Int. 2011;79:825–42.PubMedCrossRef

14.

• Coffin CS, Stock PG, Dove LM, et al. Virologic and clinical outcomes of hepatitis B virus infection in HIV-HBV co-infected transplant recipients. Am J Transplant. 2010;10:1268–75. A prospective cohort study of HIV-hepatitis B virus (HBV) co-infected patients transplanted between 2001-2007. Compared with 20 HBV monoinfected patients on similar HBV, patient and graft survival were similar.PubMedCrossRef

15.

•• Terrault NA, Roland ME, Schiano T, et al. Outcomes of liver transplant recipients with hepatitis C and human immunodeficiency virus coinfection. Liver Transpl. 2012;18:716–26. A prospective, multicenter US cohort study comparing patient and graft survival for 89 HCV/HIV-co-infected patients and 2 control groups: 235 HCV-monoinfected liver transplant controls and all US transplant recipients who were 65 years old or older. Patient and graft survival rates were lower for HCV/HIV-co-infected liver transplant patients compared to HCV-monoinfected liver transplant patients, and rates of treated acute rejection (but not the rates of HCV disease severity) were significantly higher for HCV/HIV-co-infected recipients versus HCV-infected recipients. The authors concluded that HCV per se is not a contraindication to liver transplant in HIV-infected patients, but recipient and donor selection and the management of acute rejection strongly influence outcomes.PubMedCrossRef

16.

Harbell J, Fung J, Nissen N, et al. Surgical complications in 275 HIV-infected liver and/or kidney transplantation recipients. Surgery. 2012;152:376–81.PubMedCrossRef

17.

•• Stock PG, Barin B, Murphy B, et al. Outcomes of kidney transplantation in HIV-infected recipients. N Engl J Med. 2010;363:2004–14. A prospective, nonrandomized trial of kidney transplantation in 150 HIV-infected patients. The patient survival of HIV-infected recipients in this study was similar to that observed in HIV-uninfected recipients older than 65 years of age during the same time period. Rejection rates were higher in HIV-infected kidney recipients than what is observed in non-infected patients. However, the higher observed rejection rates did not have a significant impact on overall short-term graft survival.PubMedCrossRef

18.

Stock PG, Roland ME, Carlson L, et al. Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study. Transplantation. 2003;76:370–5.PubMedCrossRef

19.

Stock PG, Roland ME. Evolving clinical strategies for transplantation in the HIV-positive recipient. Transplantation. 2007;84:563–71.PubMedCrossRef

20.

Abbott KC, Swanson SJ, Agodoa LY, Kimmel PL. Human immunodeficiency virus infection and kidney transplantation in the era of highly active antiretroviral therapy and modern immunosuppression. J Am Soc Nephrol. 2004;15:1633–9.PubMedCrossRef

21.

Kumar MS, Sierka DR, Damask AM, et al. Safety and success of kidney transplantation and concomitant immunosuppression in HIV-positive patients. Kidney Int. 2005;67:1622–9.PubMedCrossRef

22.

Qiu J, Terasaki PI, Waki K, et al. HIV-positive renal recipients can achieve survival rates similar to those of HIV-negative patients. Transplantation. 2006;81:1658–61.PubMedCrossRef

23.

Pelletier SJ, Norman SP, Christensen LL, et al. Review of transplantation in HIV patients during the HAART era. Clin Transpl. 2004;63–82.

24.

Carter JT, Melcher ML, Carlson LL, et al. Thymoglobulin-associated Cd4+ T-cell depletion and infection risk in HIV-infected renal transplant recipients. Am J Transplant. 2006;6:753–60.PubMedCrossRef

25.

Neff GW, Bonham A, Tzakis AG, et al. Orthotopic liver transplantation in patients with human immunodeficiency virus and end-stage liver disease. Liver Transpl. 2003;9:239–47.PubMedCrossRef

26.

Prachalias AA, Pozniak A, Taylor C, et al. Liver transplantation in adults co-infected with HIV. Transplantation. 2001;72:1684–8.PubMedCrossRef

27.

Ragni MV, Belle SH, Im K, et al. Survival of human immunodeficiency virus-infected liver transplant recipients. J Infect Dis. 2003;188:1412–20.PubMedCrossRef

28.

• Cooper C, Kanters S, Klein M, et al. Liver transplant outcomes in HIV-infected patients: a systematic review and meta-analysis with synthetic cohort. AIDS. 2011;25:777–86. A meta-analysis to evaluate the effectiveness of liver transplantation in HIV-hepatitis co-infected patients. Within the HIV-infected population evaluated, HIV-hepatitis B virus (HBV) co-infection was associated with optimal survival. Individuals with an undetectable HIV viral load at the time of transplantation were more likely to survive when compared to those with detectable HIV viremia.PubMedCrossRef

29.

Terrault NA, Carter JT, Carlson L, et al. Outcome of patients with hepatitis B virus and human immunodeficiency virus infections referred for liver transplantation. Liver Transpl. 2006;12:801–7.PubMedCrossRef

30.

•• Miro JM, Montejo M, Castells L, et al. Outcome of HCV/HIV-co-infected liver transplant recipients: a prospective and multicenter cohort study. Am J Transplant. 2012;12:1866–76. A prospective multicenter study evaluating eighty-four HCV/HIV-co-infected and 252-matched HCV-monoinfected liver transplant recipients. 5-year survival in HCV/HIV-co-infected liver recipients was lower than in HCV-monoinfected recipients, although an important subset with a favorable prognosis was identified in the HCV/HIV-co-infected group.PubMedCrossRef

31.

Heredia A, Margolis D, Oldach D, et al. Abacavir in combination with the inosine monophosphate dehydrogenase (IMPDH)-inhibitor mycophenolic acid is active against multidrug-resistant HIV-1. J Acquir Immune Defic Syndr. 1999;22:406–7.PubMed

32.

Margolis D, Heredia A, Gaywee J, et al. Abacavir and mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, have profound and synergistic anti-HIV activity. J Acquir Immune Defic Syndr. 1999;21:362–70.PubMed

33.

Andrieu JM, Even P, Venet A, et al. Effects of cyclosporin on T-cell subsets in human immunodeficiency virus disease. Clin Immunol Immunopathol. 1988;47:181–98.PubMedCrossRef

34.

Groux H, Torpier G, Monte D, et al. Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med. 1992;175:331–40.PubMedCrossRef

35.

Schwarz A, Offermann G, Keller F, et al. The effect of cyclosporine on the progression of human immunodeficiency virus type 1 infection transmitted by transplantation–data on four cases and review of the literature. Transplantation. 1993;55:95–103.PubMedCrossRef

36.

Streblow DN, Kitabwalla M, Malkovsky M, Pauza CD. Cyclophilin a modulates processing of human immunodeficiency virus type 1 p55Gag: mechanism for antiviral effects of cyclosporin A. Virology. 1998;245:197–202.PubMedCrossRef

37.

Rizzardi GP, Harari A, Capiluppi B, et al. Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy. J Clin Invest. 2002;109:681–8.PubMed

38.

Stallone G, Schena A, Infante B, et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med. 2005;352:1317–23.PubMedCrossRef

39.

Heredia A, Amoroso A, Davis C, et al. Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines: an approach to suppress R5 strains of HIV-1. Proc Natl Acad Sci U S A. 2003;100:10411–6.PubMedCrossRef

40.

Gilliam BL, Heredia A, Devico A, et al. Rapamycin reduces CCR5 mRNA levels in macaques: potential applications in HIV-1 prevention and treatment. AIDS. 2007;21:2108–10.PubMedCrossRef

41.

Izzedine H, Launay-Vacher V, Baumelou A, Deray G. Antiretroviral and immunosuppressive drug-drug interactions: an update. Kidney Int. 2004;66:532–41.PubMedCrossRef

42.

Frassetto L, Baluom M, Jacobsen W, et al. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005;80:13–7.PubMedCrossRef

43.

Frassetto L, Thai T, Aggarwal AM, et al. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metab Pharmacokinet. 2003;18:114–20.PubMedCrossRef

44.

Vogel M, Voigt E, Michaelis HC, et al. Management of drug-to-drug interactions between cyclosporine A and the protease-inhibitor lopinavir/ritonavir in liver-transplanted HIV-infected patients. Liver Transpl. 2004;10:939–44.PubMedCrossRef

45.

Frassetto LA, Browne M, Cheng A, et al. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Am J Transplant. 2007;7:2816–20.PubMedCrossRef

46.

McMahon MA, Jilek BL, Brennan TP, et al. The HBV drug entecavir - effects on HIV-1 replication and resistance. N Engl J Med. 2007;356:2614–21.PubMedCrossRef

47.

Fox AN, Terrault NA. Individualizing hepatitis B infection prophylaxis in liver transplant recipients. J Hepatol. 2011;55:507–9.PubMedCrossRef

48.

Duclos-Vallee JC, Feray C, Sebagh M, et al. Survival and recurrence of hepatitis C after liver transplantation in patients co-infected with human immunodeficiency virus and hepatitis C virus. Hepatology. 2008;47:407–17.PubMedCrossRef

49.

Berenguer M, Palau A, Aguilera V, et al. Clinical benefits of antiviral therapy in patients with recurrent hepatitis C following liver transplantation. Am J Transplant. 2008;8:679–87.PubMedCrossRef

50.

Xirouchakis E, Triantos C, Manousou P, et al. Pegylated-interferon and ribavirin in liver transplant candidates and recipients with HCV cirrhosis: systematic review and meta-analysis of prospective controlled studies. J Viral Hepat. 2008;15:699–709.PubMedCrossRef

51.

Terrault N, Barin B, Schiano T, et al. Safety and efficacy of antiviral therapy in Hepatitis C Virus (HCV)-Human Immunodeficiency Virus (HIV) Co-infected Liver Transplant (LT) recipients. Am J Transplant. 2012;12LS3:Abs.196.

52.

Lok AS, Gardiner DF, Lawitz E, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med. 2012;366:216–24.PubMedCrossRef

53.

Ghany MG, Nelson DR, Strader DB, et al. An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology. 2011;54:1433–44.PubMedCrossRef

54.

Lawitz E, Poordad F, Kowdley KV, et al. A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1. J Hepatol. 2013;59(1):18–23

55.

Poordad F, Lawitz E, Kowdley KV, et al. Exploratory study of oral combination antiviral therapy for hepatitis C. N Engl J Med. 2013;368:45–53.PubMedCrossRef

56.

Baid S, Tolkoff-Rubin N, Saidman S, et al. Acute humoral rejection in hepatitis C-infected renal transplant recipients receiving antiviral therapy. Am J Transplant. 2003;3:74–8.PubMedCrossRef

57.

Goedert JJ, Cote TR, Virgo P, et al. Spectrum of AIDS-associated malignant disorders. Lancet. 1998;351:1833–9.PubMedCrossRef

58.

Frisch M, Biggar RJ, Engels EA, Goedert JJ. Association of cancer with AIDS-related immunosuppression in adults. Jama. 2001;285:1736–45.PubMedCrossRef

59.

Clifford GM, Polesel J, Rickenbach M, et al. Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J Natl Cancer Inst. 2005;97:425–32.PubMedCrossRef

60.

Engels EA, Biggar RJ, Hall HI, et al. Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer. 2008;123:187–94.PubMedCrossRef

61.

MacDonald DC, Nelson M, Bower M, Powles T. Hepatocellular carcinoma, human immunodeficiency virus and viral hepatitis in the HAART era. World J Gastroenterol. 2008;14:1657–63.PubMedCrossRef

62.

Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet. 2007;370:59–67.PubMedCrossRef

63.

Holly EA, Ralston ML, Darragh TM, et al. Prevalence and risk factors for anal squamous intraepithelial lesions in women. J Natl Cancer Inst. 2001;93:843–9.PubMedCrossRef

64.

Palefsky JM, Holly EA, Ralston ML, et al. Effect of highly active antiretroviral therapy on the natural history of anal squamous intraepithelial lesions and anal human papillomavirus infection. J Acquir Immune Defic Syndr. 2001;28:422–8.PubMed

65.

Nissen NN, Barin B, Stock PG. Malignancy in the HIV-infected patients undergoing liver and kidney transplantation. Curr Opin Oncol. 2012;24:517–21.PubMedCrossRef

66.

• Muller E, Kahn D, Mendelson M. Renal transplantation between HIV-positive donors and recipients. N Engl J Med. 2010;362:2336–7. A report of four successful kidney transplants between HIV infected brain dead donors and HIV-infected recipients showed that with careful donor selection this can be carried out safely.PubMedCrossRef

Titel: Solid Organ Transplants in HIV-Infected Patients
verfasst von: Jack Harbell
Norah A. Terrault
Peter Stock
Publikationsdatum: 01.09.2013
Verlag: Springer US
Erschienen in: Current HIV/AIDS Reports / Ausgabe 3/2013
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-013-0170-z

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