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Current Infectious Disease Reports

Erschienen in:

01.10.2013 | Sepsis and ICU (J Russell, Section Editor)

Noncanonical Nuclear Factor Kappa B (NF-κB) Signaling and Potential for Therapeutics in Sepsis

verfasst von: Simone Thair, James A. Russell

Erschienen in: Current Infectious Disease Reports | Ausgabe 5/2013

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Abstract

NF-κB signaling plays a central role in the pathophysiology of severe sepsis and septic shock. Despite tremendous and missed efforts, novel therapeutics for severe sepsis and septic shock are still needed. Many drugs have been designed to target the canonical NF-κB signaling pathway with limited success, potentially due to the nonspecificity of the drugs for other kinases and the interaction of canonical signaling with other pathways. Here, we review the canonical and noncanonical signaling pathways of NF-κB, the cross talk and negative regulation of the two pathways, and the potential for therapeutics arising from the noncanonical NF-κB pathway in relation to the pathophysiology of septic shock.

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Titel: Noncanonical Nuclear Factor Kappa B (NF-κB) Signaling and Potential for Therapeutics in Sepsis
verfasst von: Simone Thair
James A. Russell
Publikationsdatum: 01.10.2013
Verlag: Springer US
Erschienen in: Current Infectious Disease Reports / Ausgabe 5/2013
Print ISSN: 1523-3847
Elektronische ISSN: 1534-3146
DOI: https://doi.org/10.1007/s11908-013-0362-0

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