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Current Infectious Disease Reports
Erschienen in: Current Infectious Disease Reports 11/2014

01.11.2014 | Skin, Soft Tissue, Bone and Joint Infectious Diseases (N Safdar, Section Editor)

Mycobacterial Skin and Soft Tissue Infection

verfasst von: Shu-Hua Wang, Preeti Pancholi

Erschienen in: Current Infectious Disease Reports | Ausgabe 11/2014

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Abstract

Mycobacterial skin and soft tissue infection (SSTI) includes nontuberculous mycobacterial (NTM) infections, tuberculosis (TB), and leprosy. Diagnosis of mycobacterial SSTI can be challenging due to diverse clinical presentation, low yield from cultured specimens, and nonspecific histopathology on tissue biopsy. In addition, immunosuppressed patients may present with atypical or disseminated disease. Despite aggressive medical treatment and often with surgical intervention, results may be suboptimal with poor outcomes. Regimens typically require multiple antibiotics for extended periods of time and are often complicated by medication side effects and drug-drug interactions. Biopsy with culture is the gold standard for diagnosis, but newer molecular diagnostics and proteomics such as matrix-assisted laser desorption ionization-time of flight mass spectrometry have improved diagnosis with increased identification of clinically significant mycobacteria species in clinically relevant time frames. We will review updates in diagnostic tests along with clinical presentation and treatment of mycobacterial SSTI for NTM, TB, and leprosy.
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Metadaten
Titel
Mycobacterial Skin and Soft Tissue Infection
verfasst von
Shu-Hua Wang
Preeti Pancholi
Publikationsdatum
01.11.2014
Verlag
Springer US
Erschienen in
Current Infectious Disease Reports / Ausgabe 11/2014
Print ISSN: 1523-3847
Elektronische ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-014-0438-5

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