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Current Neurology and Neuroscience Reports
Erschienen in: Current Neurology and Neuroscience Reports 9/2017

01.09.2017 | Dementia (K Marder, Section Editor)

New Therapeutic Strategies for Lewy Body Dementias

verfasst von: Latha Velayudhan, Dominic Ffytche, Clive Ballard, Dag Aarsland

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 9/2017

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Abstract

This article reviews current treatment strategies and recent advances for the Lewy body dementias (LBDs). Current available symptom treatment strategies are based on monoaminergic, cholinergic and glutaminergic neurotransmitter systems. Relatively robust evidence exists for cholinesterase inhibitors for cognitive impairment in LBD and in Parkinson’s disease for antidepressants, clozapine and recently pimavanserin for psychosis. interpidine (RVT 101) and nelotanserin are currently under investigation. Non-pharmacological interventions, such as cognitive stimulation, physical exercises and neuromodulation strategies, may be useful in Parkinson’s disease but have not yet been tested in dementias. Disease-modifying approaches are aimed at preventing, slowing or ameliorating the production, aggregation and deposition of pathological proteins, including immunotherapy targeting α-synuclein and an ongoing trial using ambroxol which increases glucocerebrosidase activity to lower the levels of the protein alpha-synuclein. Other disease-modifying clinical trials are using agents to augment insulin signalling, stem cell therapy, reducing amyloid pathology and gene therapy.
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Metadaten
Titel
New Therapeutic Strategies for Lewy Body Dementias
verfasst von
Latha Velayudhan
Dominic Ffytche
Clive Ballard
Dag Aarsland
Publikationsdatum
01.09.2017
Verlag
Springer US
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 9/2017
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-017-0778-2

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