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Current Neurology and Neuroscience Reports
Erschienen in: Current Neurology and Neuroscience Reports 12/2018

01.12.2018 | Critical Care (S Mayer, Section Editor)

Septic Encephalopathy

verfasst von: Chiara Robba, Ilaria Alice Crippa, Fabio Silvio Taccone

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 12/2018

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Abstract

Purpose of the Review

To discuss the diagnostic approach to patients with septic encephalopathy as well as the need for specific neuro-monitoring and the perspectives on future therapeutic approaches in this setting.

Recent Findings

Most of data-concern experimental studies evaluating the pathophysiology of septic encephalopathy. A combination of neurodegenerative pathways with neurovascular injury is the cornerstone for the development of such complication and the long-term neurological sequelae among survivors.

Summary

Septic encephalopathy is a common complication in septic patients. Clinical presentation may range from mild confusion and disorientation to convulsions and deep coma. The diagnosis of septic encephalopathy is made difficult by the lack of any specific clinical and non-clinical feature, in particular among sedated patients in whom neurological examination is unreliable. In spite of the high mortality rate associated with this condition, there is no prophylactic or targeted therapy to reduce or minimize brain damage in septic patients and clinical management is limited to the treatment of the underlying infection.
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Metadaten
Titel
Septic Encephalopathy
verfasst von
Chiara Robba
Ilaria Alice Crippa
Fabio Silvio Taccone
Publikationsdatum
01.12.2018
Verlag
Springer US
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 12/2018
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-018-0895-6

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