Erschienen in:
01.04.2012 | Head and Neck Cancers (EY Hanna, Section Editor)
Functional Outcomes after Chemoradiotherapy of Laryngeal and Pharyngeal Cancers
verfasst von:
Katherine A. Hutcheson, Jan S. Lewin
Erschienen in:
Current Oncology Reports
|
Ausgabe 2/2012
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Abstract
Organ preservation regimens that combine chemotherapy and radiotherapy (chemoradiotherapy) are increasingly used as the primary treatment of laryngeal and pharyngeal cancers. Meta-analytic data show a survival benefit with combined modality therapy, but the functional sequelae can be significant. Dysphagia is recognized as a common and often devastating late effect of chemoradiotherapy. This review examines functional outcomes after chemoradiotherapy for laryngeal and pharyngeal cancers, with a particular emphasis on dysphagia. Topics examined include the burden of dysphagia after chemoradiation, pathophysiology of dysphagia, baseline functioning, recommendations to improve long-term function, and voice outcomes.