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Current Oncology Reports

Erschienen in:

01.03.2019 | Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)

Management of Adrenocortical Carcinoma

verfasst von: Sina Jasim, Mouhammed Amir Habra

Erschienen in: Current Oncology Reports | Ausgabe 3/2019

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Abstract

Purpose of Review

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy typically with poor prognosis. This review aims to summarize the current knowledge regarding the clinical management of ACC.

Recent Findings

Surgery remains the cornerstone for localized ACC management. In more advanced cases, debulking surgery when feasible can help with hormonal control and may allow the initiation of systemic therapy. Over the last few years, our understanding of ACC molecular pathogenesis has expanded with no significant change in treatment options. Platinum-based chemotherapy is the gold standard in metastatic ACC despite suboptimal efficacy. Tyrosine kinase inhibitor use did not result in meaningful benefit in ACC patients. Multiple clinical trials are currently exploring the role of immunotherapy in ACC.

Summary

Despite the remarkable improvement in our understanding of the molecular signature and pathways in ACC, this knowledge did not yield a major breakthrough in management of advanced ACC. Multi-institutional and international collaborations are needed to identify promising treatments and new therapeutic targets to improve the care of ACC patients.

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Titel: Management of Adrenocortical Carcinoma
verfasst von: Sina Jasim
Mouhammed Amir Habra
Publikationsdatum: 01.03.2019
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 3/2019
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-019-0773-7

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Purpose of Review

Recent Findings

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