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01.03.2019 | Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)

Current Status and Future Direction of Immunotherapy in Urothelial Carcinoma

verfasst von: Michael Lattanzi, Arjun V. Balar

Erschienen in: Current Oncology Reports | Ausgabe 3/2019

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Abstract

Purpose of Review

Since 2016, five new programmed cell death protein 1/ligand 1 (PD-1/L1) checkpoint inhibitors have been approved for metastatic urothelial carcinoma. This review will summarize the data supporting the widespread use of these agents and highlight areas of ongoing clinical development.

Recent Findings

PD-1/L1 axis inhibition has demonstrated clear superiority to chemotherapy for the treatment of metastatic urothelial cancer in the second-line setting. A multitude of ongoing studies are investigating the feasibility and efficacy of incorporating established and novel immunotherapies into earlier lines of therapy, including non-metastatic muscle-invasive bladder cancer and even non-muscle-invasive disease. Early-phase clinical trials have begun to explore the safety and activity of novel immune-oncology combinations across a range of clinical settings.

Summary

Immunotherapy has a clearly defined role in the treatment of metastatic urothelial cancer both in the platinum-refractory setting and in the first-line cisplatin-ineligible setting. Ongoing clinical trials will dictate how to best incorporate immunotherapy into earlier lines of therapy and define the safety and activity of novel immunotherapy agents and combinations.

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Titel: Current Status and Future Direction of Immunotherapy in Urothelial Carcinoma
verfasst von: Michael Lattanzi
Arjun V. Balar
Publikationsdatum: 01.03.2019
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 3/2019
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-019-0775-5

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24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Current Status and Future Direction of Immunotherapy in Urothelial Carcinoma

Abstract

Purpose of Review

Recent Findings

Summary

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie