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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 4/2016

04.06.2016 | Biomechanics (M Silva and K Jepsen, Section Editors)

Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk

verfasst von: Jeffry S. Nyman, Mathilde Granke, Robert C. Singleton, George M. Pharr

Erschienen in: Current Osteoporosis Reports | Ausgabe 4/2016

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Abstract

Tissue-level mechanical properties characterize mechanical behavior independently of microscopic porosity. Specifically, quasi-static nanoindentation provides measurements of modulus (stiffness) and hardness (resistance to yielding) of tissue at the length scale of the lamella, while dynamic nanoindentation assesses time-dependent behavior in the form of storage modulus (stiffness), loss modulus (dampening), and loss factor (ratio of the two). While these properties are useful in establishing how a gene, signaling pathway, or disease of interest affects bone tissue, they generally do not vary with aging after skeletal maturation or with osteoporosis. Heterogeneity in tissue-level mechanical properties or in compositional properties may contribute to fracture risk, but a consensus on whether the contribution is negative or positive has not emerged. In vivo indentation of bone tissue is now possible, and the mechanical resistance to microindentation has the potential for improving fracture risk assessment, though determinants are currently unknown.
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Metadaten
Titel
Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk
verfasst von
Jeffry S. Nyman
Mathilde Granke
Robert C. Singleton
George M. Pharr
Publikationsdatum
04.06.2016
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 4/2016
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-016-0314-3

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