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Current Osteoporosis Reports

Erschienen in:

22.06.2017 | Pediatrics (L Ward and E Imel, Section Editors)

Denosumab: an Emerging Therapy in Pediatric Bone Disorders

Erschienen in: Current Osteoporosis Reports | Ausgabe 4/2017

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Abstract

Purpose of Review

Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children.

Recent Findings

Considerable safety and efficacy data exists for denosumab treatment of adults with osteoporosis, bone metastases, and giant cell tumors. Pediatric data is limited; however, evidence suggests denosumab may be beneficial in decreasing bone turnover, increasing bone density, and preventing growth of certain skeletal neoplasms in children. Denosumab’s effect on bone turnover is rapidly reversible after drug discontinuation, representing a key difference from bisphosphonates. Rebound increased bone turnover has led to severe hypercalcemia in several pediatric patients.

Summary

Denosumab is a promising therapy for pediatric skeletal disorders. At present, safety concerns related to rebounding bone turnover and mineral homeostasis impact use of denosumab in children. Research is needed to determine if and how these effects can be mitigated.

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Titel: Denosumab: an Emerging Therapy in Pediatric Bone Disorders
Publikationsdatum: 22.06.2017
Erschienen in: Current Osteoporosis Reports / Ausgabe 4/2017
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-017-0380-1

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Springer Medizin

Denosumab: an Emerging Therapy in Pediatric Bone Disorders

Abstract

Purpose of Review

Recent Findings

Summary

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Purpose of Review

Recent Findings

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