Skip to main content
Erschienen in: Current Osteoporosis Reports 1/2018

29.01.2018 | Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors)

Diabetes and Abdominal Aortic Calcification—a Systematic Review

verfasst von: Emilie Frey Bendix, Eskild Johansen, Thomas Ringgaard, Martin Wolder, Jakob Starup-Linde

Erschienen in: Current Osteoporosis Reports | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

A systematic literature review was performed to evaluate diabetes mellitus (DM) as a risk factor of abdominal aortic calcification (AAC), and address factors that might contribute to the development of AAC in DM patients.

Recent Findings

DM is an independent risk factor of AAC development. Bone metabolism along with lifestyle factors among DM patients makes them more prone to AAC. Hip and vertebral fractures, high phosphate, smoking, hypertension, and low osteocalcin could make DM patients prone to AAC. Low levels of high-density lipoprotein (HDL), high low-density lipoprotein (LDL), high total cholesterol/HDL ratio, low bone mineral density (BMD) may be risk factors, but the literature is more ambiguous. Body mass index (BMI) does not appear to increase risk of AAC.

Summary

High phosphate levels and low osteocalcin levels seem to be biomarkers of AAC in patients with diabetes. However, the association between DM and AAC is complicated.
Literatur
2.
Zurück zum Zitat Kalofoutis C, Piperi C, Kalofoutis A, Harris F, Phoenix D, Singh J. Type II diabetes mellitus and cardiovascular risk factors: current therapeutic approaches. Exp Clin Cardiol. 2007;12(1):17–28.PubMedPubMedCentral Kalofoutis C, Piperi C, Kalofoutis A, Harris F, Phoenix D, Singh J. Type II diabetes mellitus and cardiovascular risk factors: current therapeutic approaches. Exp Clin Cardiol. 2007;12(1):17–28.PubMedPubMedCentral
23.
Zurück zum Zitat • Wei D, Zheng G, Gao Y, Guo J, Zhang T. Abdominal aortic calcification and the risk of bone fractures: a meta-analysis of prospective cohort studies. J Bone Miner Metab. 2017; This study suggests that AAC is independently associated with a higher fracture risk. • Wei D, Zheng G, Gao Y, Guo J, Zhang T. Abdominal aortic calcification and the risk of bone fractures: a meta-analysis of prospective cohort studies. J Bone Miner Metab. 2017; This study suggests that AAC is independently associated with a higher fracture risk.
24.
Zurück zum Zitat El Maghraoui A, Hamza T, Sadni S, El Maataoui A, Majjad A, Rezqi A, et al. Vitamin D status and abdominal aortic calcification in postmenopausal women. J Bone Miner Metab 2017. El Maghraoui A, Hamza T, Sadni S, El Maataoui A, Majjad A, Rezqi A, et al. Vitamin D status and abdominal aortic calcification in postmenopausal women. J Bone Miner Metab 2017.
25.
Zurück zum Zitat • Canepa M, Ameri P, AlGhatrif M, Pestelli G, Milaneschi Y, Strait JB, et al. Role of bone mineral density in the inverse relationship between body size and aortic calcification: results from the Baltimore Longitudinal Study of Aging. Atherosclerosis. 2014;235(1):169–75. This study suggests that BMD is negatively correlated with aortic calcification. Smoking, high SBP, age, and lipid lowering drugs were positively associated with AAC. CrossRefPubMedPubMedCentral • Canepa M, Ameri P, AlGhatrif M, Pestelli G, Milaneschi Y, Strait JB, et al. Role of bone mineral density in the inverse relationship between body size and aortic calcification: results from the Baltimore Longitudinal Study of Aging. Atherosclerosis. 2014;235(1):169–75. This study suggests that BMD is negatively correlated with aortic calcification. Smoking, high SBP, age, and lipid lowering drugs were positively associated with AAC. CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Confavreux CB, Szulc P, Casey R, Boutroy S, Varennes A, Vilayphiou N, et al. Higher serum osteocalcin is associated with lower abdominal aortic calcification progression and longer 10-year survival in elderly men of the MINOS cohort. J Clin Endocrinol Metab. 2013;98(3):1084–92. https://doi.org/10.1210/jc.2012-3426.CrossRefPubMed Confavreux CB, Szulc P, Casey R, Boutroy S, Varennes A, Vilayphiou N, et al. Higher serum osteocalcin is associated with lower abdominal aortic calcification progression and longer 10-year survival in elderly men of the MINOS cohort. J Clin Endocrinol Metab. 2013;98(3):1084–92. https://​doi.​org/​10.​1210/​jc.​2012-3426.CrossRefPubMed
47.
Zurück zum Zitat Wang XR, Yuan L, Zhang JJ, Hao L, Wang DG. Serum sclerostin values are associated with abdominal aortic calcification and predict cardiovascular events in patients with chronic kidney disease stages 3-5D. Nephrology (Carlton). 2017;22(4):286–92. https://doi.org/10.1111/nep.12813.CrossRef Wang XR, Yuan L, Zhang JJ, Hao L, Wang DG. Serum sclerostin values are associated with abdominal aortic calcification and predict cardiovascular events in patients with chronic kidney disease stages 3-5D. Nephrology (Carlton). 2017;22(4):286–92. https://​doi.​org/​10.​1111/​nep.​12813.CrossRef
49.
Zurück zum Zitat Tanna N, Patel K, Moore AE, Dulnoan D, Edwards S, Hampson G. The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women. J Endocrinol Investig. 2017;40(12):1345–53. https://doi.org/10.1007/s40618-017-0711-1.CrossRef Tanna N, Patel K, Moore AE, Dulnoan D, Edwards S, Hampson G. The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women. J Endocrinol Investig. 2017;40(12):1345–53. https://​doi.​org/​10.​1007/​s40618-017-0711-1.CrossRef
50.
Zurück zum Zitat Sakura T, Okuno S, Nishio E, Norimine K, Ishimura E, Yamakawa T, et al. The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study. Sci Rep. 2017;7(1):6434.CrossRefPubMedPubMedCentral Sakura T, Okuno S, Nishio E, Norimine K, Ishimura E, Yamakawa T, et al. The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study. Sci Rep. 2017;7(1):6434.CrossRefPubMedPubMedCentral
63.
Zurück zum Zitat Kimura K, Saika Y, Otani H, Fujii R, Mune M, Yukawa S. Factors associated with calcification of the abdominal aorta in hemodialysis patients. Kidney Int Suppl. 1999;71:S238–41.CrossRefPubMed Kimura K, Saika Y, Otani H, Fujii R, Mune M, Yukawa S. Factors associated with calcification of the abdominal aorta in hemodialysis patients. Kidney Int Suppl. 1999;71:S238–41.CrossRefPubMed
70.
Zurück zum Zitat Kim JK, Park MJ, Song YR, Kim HJ, Kim SG. Vitamin D: a possible modifying factor linking obesity to vascular calcification in hemodialysis patients. Nutr Metab (Lond). 2017;14:27.CrossRef Kim JK, Park MJ, Song YR, Kim HJ, Kim SG. Vitamin D: a possible modifying factor linking obesity to vascular calcification in hemodialysis patients. Nutr Metab (Lond). 2017;14:27.CrossRef
71.
Zurück zum Zitat Shang X, Scott D, Hodge A, Khan B, Khan N, English DR, et al. Adiposity assessed by anthropometric measures has a similar or greater predictive ability than dual-energy X-ray absorptiometry measures for abdominal aortic calcification in community-dwelling older adults. Int J Cardiovasc Imaging. 2016 Sep;32(9):1451–60. https://doi.org/10.1007/s10554-016-0920-2.CrossRefPubMed Shang X, Scott D, Hodge A, Khan B, Khan N, English DR, et al. Adiposity assessed by anthropometric measures has a similar or greater predictive ability than dual-energy X-ray absorptiometry measures for abdominal aortic calcification in community-dwelling older adults. Int J Cardiovasc Imaging. 2016 Sep;32(9):1451–60. https://​doi.​org/​10.​1007/​s10554-016-0920-2.CrossRefPubMed
82.
Zurück zum Zitat Niu Y, Zhang W, Yang Z, Li X, Wen J, Wang S, et al. Association of plasma osteoprotegerin levels with the severity of lower extremity arterial disease in patients with type 2 diabetes. BMC Cardiovasc Disord. 2015;15:86.CrossRefPubMedPubMedCentral Niu Y, Zhang W, Yang Z, Li X, Wen J, Wang S, et al. Association of plasma osteoprotegerin levels with the severity of lower extremity arterial disease in patients with type 2 diabetes. BMC Cardiovasc Disord. 2015;15:86.CrossRefPubMedPubMedCentral
85.
Zurück zum Zitat Starup-Linde J. Diabetes, biochemical markers of bone turnover, diabetes control, and bone. Front Endocrinol (Lausanne). 2013;4:21. Starup-Linde J. Diabetes, biochemical markers of bone turnover, diabetes control, and bone. Front Endocrinol (Lausanne). 2013;4:21.
Metadaten
Titel
Diabetes and Abdominal Aortic Calcification—a Systematic Review
verfasst von
Emilie Frey Bendix
Eskild Johansen
Thomas Ringgaard
Martin Wolder
Jakob Starup-Linde
Publikationsdatum
29.01.2018
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 1/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-018-0418-z

Weitere Artikel der Ausgabe 1/2018

Current Osteoporosis Reports 1/2018 Zur Ausgabe

Muscle and Bone (L Bonewald and M Hamrick, Section Editors)

The Role of Bone Secreted Factors in Burn-Induced Muscle Cachexia

Secondary Causes of Osteoporosis (S Warden, Section Editor)

Linking the Gut Microbiota to Bone Health in Anorexia Nervosa

Genetics (M Johnson and S Ralston, Section Editors)

Genetics of Osteopetrosis

Genetics (M Johnson and S Ralston, Section Editors)

Regulation of Bone Metabolism by microRNAs

Osteocytes (T Bellido and J Klein Nulend, Section Editors)

Solute Transport in the Bone Lacunar-Canalicular System (LCS)

Skeletal Development (P Trainor and K Svoboda, Section Editors)

Exosomes in Extracellular Matrix Bone Biology

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.