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Erschienen in: Current Osteoporosis Reports 3/2019

26.03.2019 | Osteocytes (J Klein Nulend, Section editor)

Pro-inflammatory Cytokines and Osteocytes

verfasst von: Miao Zhou, Shuyi Li, Janak L. Pathak

Erschienen in: Current Osteoporosis Reports | Ausgabe 3/2019

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Abstract

Purpose of Review

An elevated level of pro-inflammatory cytokines in inflammatory conditions causes bone loss and disrupts vital organ function. Osteocytes comprise > 95% of the cellular component in bone tissue, produce a range of cytokines and signaling molecules, and influence bone and other organ function. In this review, we hypothesized that an elevated level of pro-inflammatory cytokines in inflammatory conditions affects osteocyte survival and function thereby possibly amplifying inflammation, and causing bone loss and non-bone clinical complications.

Recent Findings

Several studies have reported that the elevated level of pro-inflammatory cytokines in inflammatory conditions alters osteocyte mechanosensitivity, causes osteocyte apoptosis, and modulates osteocyte-derived production of various inflammatory cytokines and signaling molecules. Cytokines and signaling molecules released from osteocytes affect surrounding bone cells and distant organ function in a paracrine and endocrine fashion.

Summary

Inflammatory diseases including diabetes, chronic kidney disease, rheumatoid arthritis, and periodontitis affect osteocyte survival and function, and upregulate osteocyte-derived expression of sclerostin, RANKL, TNFα, FGF23, DKK1, and other signaling molecules.
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Metadaten
Titel
Pro-inflammatory Cytokines and Osteocytes
verfasst von
Miao Zhou
Shuyi Li
Janak L. Pathak
Publikationsdatum
26.03.2019
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 3/2019
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-019-00507-z

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