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Current Pain and Headache Reports
Erschienen in: Current Pain and Headache Reports 7/2016

01.07.2016 | Secondary Headache (M Robbins, Section Editor)

Spreading Depression in Primary and Secondary Headache Disorders

verfasst von: Shih-Pin Chen, Cenk Ayata

Erschienen in: Current Pain and Headache Reports | Ausgabe 7/2016

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Abstract

Purpose of Review

Spreading depression (SD) is a wave of simultaneous and near-complete depolarization of virtually all cells in brain tissue associated with a transient “depression” of all spontaneous or evoked electrical activity in the brain. SD is widely accepted as the pathophysiological event underlying migraine aura and may play a role in headache pathogenesis in secondary headache disorders such as ischemic stroke, subarachnoid or intracerebral hemorrhage, traumatic brain injury, and epilepsy. Here, we provide an overview of the pathogenic mechanisms and propose plausible hypotheses on the involvement of SD in primary and secondary headache disorders.

Recent Findings

SD can activate downstream trigeminovascular nociceptive pathways to explain the cephalgia in migraine, and possibly in secondary headache disorders as well. In healthy, well-nourished tissue (such as migraine), the intense transmembrane ionic shifts, the cell swelling, and the metabolic and hemodynamic responses associated with SD do not cause tissue injury; however, when SD occurs in metabolically compromised tissue (e.g., in ischemic stroke, intracranial hemorrhage, or traumatic brain injury), it can lead to irreversible depolarization, injury, and neuronal death. Recent non-invasive technologies to detect SDs in human brain injury may aid in the investigation of SD in headache disorders in which invasive recordings are not possible.

Summary

SD explains migraine aura and progression of neurological deficits associated with other neurological disorders. Studying the nature of SD in headache disorders might provide pathophysiological insights for disease and lead to targeted therapies in the era of precision medicine.
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Metadaten
Titel
Spreading Depression in Primary and Secondary Headache Disorders
verfasst von
Shih-Pin Chen
Cenk Ayata
Publikationsdatum
01.07.2016
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 7/2016
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-016-0574-8

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