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Erschienen in: Current Psychiatry Reports 11/2014

01.11.2014 | Attention-Deficit Disorder (A Rostain, Section Editor)

Use of EEG to Diagnose ADHD

verfasst von: Agatha Lenartowicz, Sandra K. Loo

Erschienen in: Current Psychiatry Reports | Ausgabe 11/2014

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Abstract

Electroencephalography (EEG) has, historically, played a focal role in the assessment of neural function in children with attention deficit hyperactivity disorder (ADHD). We review here the most recent developments in the utility of EEG in the diagnosis of ADHD, with emphasis on the most commonly used and emerging EEG metrics and their reliability in diagnostic classification. Considering the clinical heterogeneity of ADHD and the complexity of information available from the EEG signals, we suggest that considerable benefits are to be gained from multivariate analyses and a focus towards understanding of the neural generators of EEG. We conclude that while EEG cannot currently be used as a diagnostic tool, vast developments in analytical and technological tools in its domain anticipate future progress in its utility in the clinical setting.
Glossar
Alpha band
Referring to oscillations in the range of 8-15 Hz
Beta band
Referring to oscillations in the range of 16-30 Hz
Delta band
Referring to oscillations <4 Hz
Event-related desynchronization (ERD)
Decrease in power of a frequency following a stimulus in event-related spectral analysis relative to pre-event; thought to arise from decreased synchronization of neural activity in that frequency
Event-related potential (ERP)
The average EEG signal in a time window following an event of interest (e.g., beep), computed over many repetitions of that event; typically associated with transient cortical dynamics in response to a stimulus or response
Event-related spectral analysis
The average power in a time window following an event of interest (e.g., beep), computed over many repetitions of that event; computed separately across many frequencies; typically associated with transient changes in brain state
Event-related synchronization (ERS)
Increase in power of a frequency following a stimulus in event-related spectral analysis relative to pre-event; thought to arise from increased synchronization of neural activity in that frequency
Feature
A descriptor or metric of EEG data; can be categorized into subclasses (see below) such as spectral, temporal, spatial or fractal
Fractal
Referring to characterization of jaggedness or serratedness of an EEG time series
Frequency
Number of cycles of an oscillation occurring per unit time; units of Hertz (Hz) or cycles/sec; distinguishes between “fast” and “slow” oscillations
Gamma band
Referring to oscillations above 30 Hz
Independent components analysis
Statistical technique that attempts to parse multivariate data (e.g., signal across many electrodes in EEG) into latent components that describe patterns of variables that covary across some other variable (e.g., time); these components are selected to be maximally statistically independent
Machine learning
The study and design of computer-based statistical algorithms that can learn from the data; typically designed to predict categorical outcome variables such as diagnosis; logistic regression is a univariate example of Machine Learning
Multidimensional
Simultaneous observation and analysis of more than one domain of data (e.g., ERP and performance measures)
Multivariate
Simultaneous observation and analysis of more than one outcome variable
Power
A measure of the amplitude of oscillations of a particular frequency in an EEG time course; typically associated with brain state
Spatial
Referring to characterization of electrode or cortical source of EEG time series
Spectral
Referring to characterization of frequency content of EEG time series
Spectral analysis
Quantification of time series in terms of power across frequencies, producing a power “spectrum”
Synchronization
The degree to which two or more neural units (cells or populations) show oscillations of a particular frequency that are the same across time (i.e., have the same phase and amplitude); the metric of “coherence” is sometimes used in analog to the “correlation” coefficient, to quantify this co-variation
Temporal
Referring to characterization of time content of EEG time series
Theta band
Referring to oscillations in the range of 4-7 Hz
Literatur
1.
Zurück zum Zitat Jasper HH, Solomon P, Bradley C. Electroencephalographic analyses of behavior problem children. Am J Psychiatr. 1938;95(3):641–58. Jasper HH, Solomon P, Bradley C. Electroencephalographic analyses of behavior problem children. Am J Psychiatr. 1938;95(3):641–58.
2.
Zurück zum Zitat Bandettini PA. Twenty years of functional MRI: the science and the stories. Neuroimage. 2012;62(2):575–88.PubMedCrossRef Bandettini PA. Twenty years of functional MRI: the science and the stories. Neuroimage. 2012;62(2):575–88.PubMedCrossRef
3.
Zurück zum Zitat Savoy RL. History and future directions of human brain mapping and functional neuroimaging. Acta Psychol (Amst). 2001;107(1–3):9–42.CrossRef Savoy RL. History and future directions of human brain mapping and functional neuroimaging. Acta Psychol (Amst). 2001;107(1–3):9–42.CrossRef
4.
Zurück zum Zitat Weder N. Are we there yet? Electroencephalography as a diagnostic tool for attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2013;52(11):1119–20.PubMedCrossRef Weder N. Are we there yet? Electroencephalography as a diagnostic tool for attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2013;52(11):1119–20.PubMedCrossRef
5.
Zurück zum Zitat Cortese S, Castellanos FX. Neuroimaging of attention-deficit/hyperactivity disorder: current neuroscience-informed perspectives for clinicians. Curr Psychiatry Rep. 2012;14(5):568–78.PubMedCrossRef Cortese S, Castellanos FX. Neuroimaging of attention-deficit/hyperactivity disorder: current neuroscience-informed perspectives for clinicians. Curr Psychiatry Rep. 2012;14(5):568–78.PubMedCrossRef
6.
7.•
Zurück zum Zitat Johnstone SJ, Barry RJ, Clarke AR. Ten years on: a follow-up review of ERP research in attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2013;124(4):644–57. Comprehensive review of the last decade of ERP findings in ADHD.PubMedCrossRef Johnstone SJ, Barry RJ, Clarke AR. Ten years on: a follow-up review of ERP research in attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2013;124(4):644–57. Comprehensive review of the last decade of ERP findings in ADHD.PubMedCrossRef
8.
Zurück zum Zitat Barry RJ, Clarke AR, Johnstone SJ. A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography. Clin Neurophysiol. 2003;114(2):171–83.PubMedCrossRef Barry RJ, Clarke AR, Johnstone SJ. A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography. Clin Neurophysiol. 2003;114(2):171–83.PubMedCrossRef
9.
Zurück zum Zitat Lubar JF. Discourse on the development of EEG diagnostics and biofeedback for attention-deficit/hyperactivity disorders. Biofeedback Self Regul. 1991;16(3):201–25.PubMedCrossRef Lubar JF. Discourse on the development of EEG diagnostics and biofeedback for attention-deficit/hyperactivity disorders. Biofeedback Self Regul. 1991;16(3):201–25.PubMedCrossRef
10.
Zurück zum Zitat Snyder SM, Hall JR. A meta-analysis of quantitative EEG power associated with attention-deficit hyperactivity disorder. J Clin Neurophysiol. 2006;23(5):440–55.PubMedCrossRef Snyder SM, Hall JR. A meta-analysis of quantitative EEG power associated with attention-deficit hyperactivity disorder. J Clin Neurophysiol. 2006;23(5):440–55.PubMedCrossRef
11.
Zurück zum Zitat Boutros N, Fraenkel L, Feingold A. A four-step approach for developing diagnostic tests in psychiatry: EEG in ADHD as a test case. J Neuropsychiatry Clin Neurosci. 2005;17(4):455–64.PubMedCrossRef Boutros N, Fraenkel L, Feingold A. A four-step approach for developing diagnostic tests in psychiatry: EEG in ADHD as a test case. J Neuropsychiatry Clin Neurosci. 2005;17(4):455–64.PubMedCrossRef
12.••
Zurück zum Zitat Arns M, Conners CK, Kraemer HC. A decade of EEG theta/beta ratio research in ADHD: a meta-analysis. J Atten Disord. 2013;17(5):374–83. Key meta-analysis that showed inconsistency of theta/beta ratio in distinguishing between ADHD and controls and highlighted that this metric decreased linearly with year of pulication.PubMedCrossRef Arns M, Conners CK, Kraemer HC. A decade of EEG theta/beta ratio research in ADHD: a meta-analysis. J Atten Disord. 2013;17(5):374–83. Key meta-analysis that showed inconsistency of theta/beta ratio in distinguishing between ADHD and controls and highlighted that this metric decreased linearly with year of pulication.PubMedCrossRef
13.
Zurück zum Zitat Quintana H, Snyder SM, Purnell W, Aponte C, Sita J. Comparison of a standard psychiatric evaluation to rating scales and EEG in the differential diagnosis of attention-deficit/hyperactivity disorder. Psychiatry Res. 2007;152(2–3):211–22.PubMedCrossRef Quintana H, Snyder SM, Purnell W, Aponte C, Sita J. Comparison of a standard psychiatric evaluation to rating scales and EEG in the differential diagnosis of attention-deficit/hyperactivity disorder. Psychiatry Res. 2007;152(2–3):211–22.PubMedCrossRef
14.
Zurück zum Zitat Monastra VJ, Lubar JF, Linden M. The development of a quantitative electroencephalographic scanning process for attention deficit-hyperactivity disorder: reliability and validity studies. Neuropsychology. 2001;15(1):136–44.PubMedCrossRef Monastra VJ, Lubar JF, Linden M. The development of a quantitative electroencephalographic scanning process for attention deficit-hyperactivity disorder: reliability and validity studies. Neuropsychology. 2001;15(1):136–44.PubMedCrossRef
15.
Zurück zum Zitat Snyder SM, Quintana H, Sexson SB, Knott P, et al. Blinded, multi-center validation of EEG and rating scales in identifying ADHD within a clinical sample. Psychiatry Res. 2008;159(3):346–58.PubMedCrossRef Snyder SM, Quintana H, Sexson SB, Knott P, et al. Blinded, multi-center validation of EEG and rating scales in identifying ADHD within a clinical sample. Psychiatry Res. 2008;159(3):346–58.PubMedCrossRef
16.
Zurück zum Zitat Mann CA, Lubar JF, Zimmerman AW, Miller CA, Muenchen RA. Quantitative-analysis of Eeg in boys with attention-deficit-hyperactivity disorder - controlled-study with clinical implications. Pediatr Neurol. 1992;8(1):30–6.PubMedCrossRef Mann CA, Lubar JF, Zimmerman AW, Miller CA, Muenchen RA. Quantitative-analysis of Eeg in boys with attention-deficit-hyperactivity disorder - controlled-study with clinical implications. Pediatr Neurol. 1992;8(1):30–6.PubMedCrossRef
17.
Zurück zum Zitat Satterfield JH, Dawson ME. Electrodermal correlates of hyperactivity in children. Psychophysiology. 1971;8(2):191–7.PubMedCrossRef Satterfield JH, Dawson ME. Electrodermal correlates of hyperactivity in children. Psychophysiology. 1971;8(2):191–7.PubMedCrossRef
18.
Zurück zum Zitat Ogrim G, Kropotov J, Hestad K. The quantitative EEG theta/beta ratio in attention deficit/hyperactivity disorder and normal controls: sensitivity, specificity, and behavioral correlates. Psychiatry Res. 2012;198(3):482–8.PubMedCrossRef Ogrim G, Kropotov J, Hestad K. The quantitative EEG theta/beta ratio in attention deficit/hyperactivity disorder and normal controls: sensitivity, specificity, and behavioral correlates. Psychiatry Res. 2012;198(3):482–8.PubMedCrossRef
19.
Zurück zum Zitat van Dongen-Boomsma M, Lansbergen MM, Bekker EM, Kooij JJ, et al. Relation between resting EEG to cognitive performance and clinical symptoms in adults with attention-deficit/hyperactivity disorder. Neurosci Lett. 2010;469(1):102–6.PubMedCrossRef van Dongen-Boomsma M, Lansbergen MM, Bekker EM, Kooij JJ, et al. Relation between resting EEG to cognitive performance and clinical symptoms in adults with attention-deficit/hyperactivity disorder. Neurosci Lett. 2010;469(1):102–6.PubMedCrossRef
20.
Zurück zum Zitat Loo SK, Hale TS, Macion J, Hanada G, et al. Cortical activity patterns in ADHD during arousal, activation and sustained attention. Neuropsychologia. 2009;47(10):2114–9.PubMedCrossRefPubMedCentral Loo SK, Hale TS, Macion J, Hanada G, et al. Cortical activity patterns in ADHD during arousal, activation and sustained attention. Neuropsychologia. 2009;47(10):2114–9.PubMedCrossRefPubMedCentral
21.
Zurück zum Zitat Buyck I, Wiersema JR. Resting electroencephalogram in attention deficit hyperactivity disorder: developmental course and diagnostic value. Psychiatry Res. 2014;216(3):391–7.PubMedCrossRef Buyck I, Wiersema JR. Resting electroencephalogram in attention deficit hyperactivity disorder: developmental course and diagnostic value. Psychiatry Res. 2014;216(3):391–7.PubMedCrossRef
22.
Zurück zum Zitat Liechti MD, Valko L, Muller UC, Dohnert M, et al. Diagnostic value of resting electroencephalogram in attention-deficit/hyperactivity disorder across the lifespan. Brain Topogr. 2013;26(1):135–51.PubMedCrossRef Liechti MD, Valko L, Muller UC, Dohnert M, et al. Diagnostic value of resting electroencephalogram in attention-deficit/hyperactivity disorder across the lifespan. Brain Topogr. 2013;26(1):135–51.PubMedCrossRef
23.•
Zurück zum Zitat Loo SK, Cho A, Hale TS, McGough J, et al. Characterization of the theta to beta ratio in ADHD: identifying potential sources of heterogeneity. J Atten Disord. 2013;17(5):384–92. One of the largerst studies of theta/beta ratio to date, including 871 participants – 595 youth and 276 adults – and reporting diagnostic inconsistency of theta/beta ratio. Loo SK, Cho A, Hale TS, McGough J, et al. Characterization of the theta to beta ratio in ADHD: identifying potential sources of heterogeneity. J Atten Disord. 2013;17(5):384–92. One of the largerst studies of theta/beta ratio to date, including 871 participants – 595 youth and 276 adults – and reporting diagnostic inconsistency of theta/beta ratio.
24.
Zurück zum Zitat Clarke AR, Barry RJ, Dupuy FE, McCarthy R, et al. Excess beta activity in the EEG of children with attention-deficit/hyperactivity disorder: a disorder of arousal? Int J Psychophysiol. 2013. doi:10.1016/j.ijpsycho.2013.04.009. Clarke AR, Barry RJ, Dupuy FE, McCarthy R, et al. Excess beta activity in the EEG of children with attention-deficit/hyperactivity disorder: a disorder of arousal? Int J Psychophysiol. 2013. doi:10.​1016/​j.​ijpsycho.​2013.​04.​009.
25.
Zurück zum Zitat Barry RJ, Clarke AR, Johnstone SJ, McCarthy R, Selikowitz M. Electroencephalogram theta/beta ratio and arousal in attention-deficit/hyperactivity disorder: evidence of independent processes. Biol Psychiatry. 2009;66(4):398–401.PubMedCrossRef Barry RJ, Clarke AR, Johnstone SJ, McCarthy R, Selikowitz M. Electroencephalogram theta/beta ratio and arousal in attention-deficit/hyperactivity disorder: evidence of independent processes. Biol Psychiatry. 2009;66(4):398–401.PubMedCrossRef
26.
Zurück zum Zitat Barry RJ, Clarke AR, McCarthy R, Selikowitz M, et al. EEG differences in children as a function of resting-state arousal level. Clin Neurophysiol. 2004;115(2):402–8.PubMedCrossRef Barry RJ, Clarke AR, McCarthy R, Selikowitz M, et al. EEG differences in children as a function of resting-state arousal level. Clin Neurophysiol. 2004;115(2):402–8.PubMedCrossRef
27.
Zurück zum Zitat Barry RJ, Clarke AR, Johnstone SJ, Magee CA, Rushby JA. EEG differences between eyes-closed and eyes-open resting conditions. Clin Neurophysiol. 2007;118(12):2765–73.PubMedCrossRef Barry RJ, Clarke AR, Johnstone SJ, Magee CA, Rushby JA. EEG differences between eyes-closed and eyes-open resting conditions. Clin Neurophysiol. 2007;118(12):2765–73.PubMedCrossRef
28.
Zurück zum Zitat Nazari MA, Wallois F, Aarabi A, Berquin P. Dynamic changes in quantitative electroencephalogram during continuous performance test in children with attention-deficit/hyperactivity disorder. International Journal of Pyschophysiology. 2011;81:230–236. Nazari MA, Wallois F, Aarabi A, Berquin P. Dynamic changes in quantitative electroencephalogram during continuous performance test in children with attention-deficit/hyperactivity disorder. International Journal of Pyschophysiology. 2011;81:230–236.
29.
Zurück zum Zitat Williams LM, Hermens DF, Thein T, Clark CR, Cooper NJ, Clarke SD, Lamb C, Gordon E, Kohn MR. Using brain-based cognitive measures to support clinical decisions in ADHD. Pediatr Neurol. 2010;42(2):118–126. Williams LM, Hermens DF, Thein T, Clark CR, Cooper NJ, Clarke SD, Lamb C, Gordon E, Kohn MR. Using brain-based cognitive measures to support clinical decisions in ADHD. Pediatr Neurol. 2010;42(2):118–126.
30.
Zurück zum Zitat Smith JL, Johnstone SJ, Barry RJ. Aiding diagnosis of attention-deficit/hyperactivity disorder and its subtypes: discriminant function analysis of event-related potential data. J Child Psychol Psychiatry. 2003;44(7):1067–75.PubMedCrossRef Smith JL, Johnstone SJ, Barry RJ. Aiding diagnosis of attention-deficit/hyperactivity disorder and its subtypes: discriminant function analysis of event-related potential data. J Child Psychol Psychiatry. 2003;44(7):1067–75.PubMedCrossRef
31.
Zurück zum Zitat Szuromi B, Czobor P, Komlosi S, Bitter I. P300 deficits in adults with attention deficit hyperactivity disorder: a meta-analysis. Psychol Med. 2011;41(7):1529–38.PubMedCrossRef Szuromi B, Czobor P, Komlosi S, Bitter I. P300 deficits in adults with attention deficit hyperactivity disorder: a meta-analysis. Psychol Med. 2011;41(7):1529–38.PubMedCrossRef
32.
Zurück zum Zitat Polich J, Kok A. Cognitive and biological determinants of P300 - an integrative review. Biol Psychol. 1995;41(2):103–46.PubMedCrossRef Polich J, Kok A. Cognitive and biological determinants of P300 - an integrative review. Biol Psychol. 1995;41(2):103–46.PubMedCrossRef
34.••
Zurück zum Zitat Mueller A, Candrian G, Grane VA, Kropotov JD, et al. Discriminating between ADHD adults and controls using independent ERP components and a support vector machine: a validation study. Nonlinear Biomed Phys. 2011;5:5. Methodologically excellent proof-of-concept demonstration of machine learning application to diagnosis using EEG in ADHD.PubMedCrossRefPubMedCentral Mueller A, Candrian G, Grane VA, Kropotov JD, et al. Discriminating between ADHD adults and controls using independent ERP components and a support vector machine: a validation study. Nonlinear Biomed Phys. 2011;5:5. Methodologically excellent proof-of-concept demonstration of machine learning application to diagnosis using EEG in ADHD.PubMedCrossRefPubMedCentral
35.
Zurück zum Zitat Nazhvani AD, Boostani R, Afrasiabi S, Sadatnezhad K. Classification of ADHD and BMD patients using visual evoked potential. Clin Neurol Neurosurg. 2013;115(11):2329–35.PubMedCrossRef Nazhvani AD, Boostani R, Afrasiabi S, Sadatnezhad K. Classification of ADHD and BMD patients using visual evoked potential. Clin Neurol Neurosurg. 2013;115(11):2329–35.PubMedCrossRef
36.
Zurück zum Zitat Sadatnezhad K, Boostani R, Ghanizadeh A. Classification of BMD and ADHD patients using their EEG signals. Expert Syst Appl. 2011;38(3):1956–63.CrossRef Sadatnezhad K, Boostani R, Ghanizadeh A. Classification of BMD and ADHD patients using their EEG signals. Expert Syst Appl. 2011;38(3):1956–63.CrossRef
37.
Zurück zum Zitat Ahmadlou M, Adeli H. Wavelet-synchronization methodology: a new approach for EEG-based diagnosis of ADHD. Clin EEG Neurosci. 2010;41(1):1–10.PubMedCrossRef Ahmadlou M, Adeli H. Wavelet-synchronization methodology: a new approach for EEG-based diagnosis of ADHD. Clin EEG Neurosci. 2010;41(1):1–10.PubMedCrossRef
38.
Zurück zum Zitat Abibullaev B, An J. Decision support algorithm for diagnosis of ADHD using electroencephalograms. J Med Syst. 2012;36(4):2675–88.PubMedCrossRef Abibullaev B, An J. Decision support algorithm for diagnosis of ADHD using electroencephalograms. J Med Syst. 2012;36(4):2675–88.PubMedCrossRef
39.
Zurück zum Zitat Magee CA, Clarke AR, Barry RJ, McCarthy R, Selikowitz M. Examining the diagnostic utility of EEG power measures in children with attention deficit/hyperactivity disorder. Clin Neurophysiol. 2005;116:1033–1040. Magee CA, Clarke AR, Barry RJ, McCarthy R, Selikowitz M. Examining the diagnostic utility of EEG power measures in children with attention deficit/hyperactivity disorder. Clin Neurophysiol. 2005;116:1033–1040.
40.
Zurück zum Zitat Sonuga-Barke EJS, Castellanos FX. A common core dysfunction in attention-deficit/hyperactivity disorder: a scientific red herring? Behav Brain Sci. 2005;28(3):443–+. Sonuga-Barke EJS, Castellanos FX. A common core dysfunction in attention-deficit/hyperactivity disorder: a scientific red herring? Behav Brain Sci. 2005;28(3):443–+.
41.
Zurück zum Zitat Castellanos FX, Sonuga-Barke EJS, Milham MP, Tannock R. Characterizing cognition in ADHD: beyond executive dysfunction. Trends Cogn Sci. 2006;10(3):117–23.PubMedCrossRef Castellanos FX, Sonuga-Barke EJS, Milham MP, Tannock R. Characterizing cognition in ADHD: beyond executive dysfunction. Trends Cogn Sci. 2006;10(3):117–23.PubMedCrossRef
42.
Zurück zum Zitat Nigg JT, Willcutt EG, Doyle AE, Sonuga-Barke EJ. Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes? Biol Psychiatry. 2005;57(11):1224–30.PubMedCrossRef Nigg JT, Willcutt EG, Doyle AE, Sonuga-Barke EJ. Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes? Biol Psychiatry. 2005;57(11):1224–30.PubMedCrossRef
43.
44.
Zurück zum Zitat Sonuga-Barke EJ, Halperin JM. Developmental phenotypes and causal pathways in attention deficit/hyperactivity disorder: potential targets for early intervention? J Child Psychol Psychiatry. 2010;51(4):368–89.PubMedCrossRef Sonuga-Barke EJ, Halperin JM. Developmental phenotypes and causal pathways in attention deficit/hyperactivity disorder: potential targets for early intervention? J Child Psychol Psychiatry. 2010;51(4):368–89.PubMedCrossRef
45.
Zurück zum Zitat Sonuga-Barke EJ. Causal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways. Biol Psychiatry. 2005;57(11):1231–8.PubMedCrossRef Sonuga-Barke EJ. Causal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways. Biol Psychiatry. 2005;57(11):1231–8.PubMedCrossRef
46.
Zurück zum Zitat Biederman J, Spencer T. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol Psychiatry. 1999;46(9):1234–42.PubMedCrossRef Biederman J, Spencer T. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol Psychiatry. 1999;46(9):1234–42.PubMedCrossRef
47.
Zurück zum Zitat Shaw P, Eckstrand K, Sharp W, Blumenthal J, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A. 2007;104(49):19649–54.PubMedCrossRefPubMedCentral Shaw P, Eckstrand K, Sharp W, Blumenthal J, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A. 2007;104(49):19649–54.PubMedCrossRefPubMedCentral
48.
Zurück zum Zitat Sonuga-Barke EJS, Castellanos FX. Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neurosci Biobehav Rev. 2007;31(7):977–86.PubMedCrossRef Sonuga-Barke EJS, Castellanos FX. Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neurosci Biobehav Rev. 2007;31(7):977–86.PubMedCrossRef
49.
Zurück zum Zitat Clarke AR, Barry RJ, Dupuy FE, Heckel LD, et al. Behavioural differences between EEG-defined subgroups of children with attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2011;122(7):1333–41.PubMedCrossRef Clarke AR, Barry RJ, Dupuy FE, Heckel LD, et al. Behavioural differences between EEG-defined subgroups of children with attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2011;122(7):1333–41.PubMedCrossRef
50.
Zurück zum Zitat Dupuy FE, Clarke AR, Barry RJ, Selikowitz M, McCarthy R. EEG and electrodermal activity in girls with attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2014;125(3):491–9.PubMedCrossRef Dupuy FE, Clarke AR, Barry RJ, Selikowitz M, McCarthy R. EEG and electrodermal activity in girls with attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2014;125(3):491–9.PubMedCrossRef
51.
Zurück zum Zitat Dupuy FE, Clarke AR, Barry RJ, McCarthy R, Selikowitz M. EEG differences between the combined and inattentive types of attention-deficit/hyperactivity disorder in girls: a further investigation. Clin EEG Neurosci. 2013. Dupuy FE, Clarke AR, Barry RJ, McCarthy R, Selikowitz M. EEG differences between the combined and inattentive types of attention-deficit/hyperactivity disorder in girls: a further investigation. Clin EEG Neurosci. 2013.
52.•
Zurück zum Zitat Dupuy FE, Barry RJ, Clarke AR, McCarthy R, Selikowitz M. Sex differences between the combined and inattentive types of attention-deficit/hyperactivity disorder: an EEG perspective. Int J Psychophysiol. 2013;89(3):320–7. Comprehensive assessment of gender differences in EEG measures, speaking to heterogeneity of the disorder.PubMedCrossRef Dupuy FE, Barry RJ, Clarke AR, McCarthy R, Selikowitz M. Sex differences between the combined and inattentive types of attention-deficit/hyperactivity disorder: an EEG perspective. Int J Psychophysiol. 2013;89(3):320–7. Comprehensive assessment of gender differences in EEG measures, speaking to heterogeneity of the disorder.PubMedCrossRef
53.
Zurück zum Zitat Mazaheri A, Fassbender C, Coffey-Corina S, Hartanto TA, et al. Differential oscillatory electroencephalogram between attention-deficit/hyperactivity disorder subtypes and typically developing adolescents. Biol Psychiatry. 2013. Mazaheri A, Fassbender C, Coffey-Corina S, Hartanto TA, et al. Differential oscillatory electroencephalogram between attention-deficit/hyperactivity disorder subtypes and typically developing adolescents. Biol Psychiatry. 2013.
54.•
Zurück zum Zitat Willcutt EG, Nigg JT, Pennington BF, Solanto MV, et al. Validity of DSM-IV attention deficit/hyperactivity disorder symptom dimensions and subtypes. J Abnorm Psychol. 2012;121(4):991–1010. Definitive review of validity of ADHD subtypes, suggesting a lack of reliability in the diagnostic subtypes but consistency of the symptom dimensions (inattention versus hyperactivity/impulsivity).PubMedCrossRefPubMedCentral Willcutt EG, Nigg JT, Pennington BF, Solanto MV, et al. Validity of DSM-IV attention deficit/hyperactivity disorder symptom dimensions and subtypes. J Abnorm Psychol. 2012;121(4):991–1010. Definitive review of validity of ADHD subtypes, suggesting a lack of reliability in the diagnostic subtypes but consistency of the symptom dimensions (inattention versus hyperactivity/impulsivity).PubMedCrossRefPubMedCentral
55.
Zurück zum Zitat Hermens DF, Rowe DL, Gordon E, Williams LM. Integrative neuroscience approach to predict ADHD stimulant response. Expert Rev Neurother. 2006;6(5):753–63.PubMedCrossRef Hermens DF, Rowe DL, Gordon E, Williams LM. Integrative neuroscience approach to predict ADHD stimulant response. Expert Rev Neurother. 2006;6(5):753–63.PubMedCrossRef
56.
Zurück zum Zitat Gordon E, Cooper N, Rennie C, Hermens D, Williams LM. Integrative neuroscience: the role of a standardized database. Clin EEG Neurosci. 2005;36(2):64–75.PubMedCrossRef Gordon E, Cooper N, Rennie C, Hermens D, Williams LM. Integrative neuroscience: the role of a standardized database. Clin EEG Neurosci. 2005;36(2):64–75.PubMedCrossRef
57.
Zurück zum Zitat Ogrim G, Kropotov J, Brunner JF, Candrian G, et al. Predicting the clinical outcome of stimulant medication in pediatric attention-deficit/hyperactivity disorder: data from quantitative electroencephalography, event-related potentials, and a go/no-go test. Neuropsychiatr Dis Treat. 2014;10:231–42.PubMedCrossRefPubMedCentral Ogrim G, Kropotov J, Brunner JF, Candrian G, et al. Predicting the clinical outcome of stimulant medication in pediatric attention-deficit/hyperactivity disorder: data from quantitative electroencephalography, event-related potentials, and a go/no-go test. Neuropsychiatr Dis Treat. 2014;10:231–42.PubMedCrossRefPubMedCentral
58.
Zurück zum Zitat Ogrim G, Hestad KA, Brunner JF, Kropotov J. Predicting acute side effects of stimulant medication in pediatric attention deficit/hyperactivity disorder: data from quantitative electroencephalography, event-related potentials, and a continuous-performance test. Neuropsychiatr Dis Treat. 2013;9:1301–9.PubMedCrossRefPubMedCentral Ogrim G, Hestad KA, Brunner JF, Kropotov J. Predicting acute side effects of stimulant medication in pediatric attention deficit/hyperactivity disorder: data from quantitative electroencephalography, event-related potentials, and a continuous-performance test. Neuropsychiatr Dis Treat. 2013;9:1301–9.PubMedCrossRefPubMedCentral
59.
Zurück zum Zitat Clarke AR, Barry RJ, Dupuy FE, McCarthy R, et al. Childhood EEG as a predictor of adult attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2011;122(1):73–80.PubMedCrossRef Clarke AR, Barry RJ, Dupuy FE, McCarthy R, et al. Childhood EEG as a predictor of adult attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2011;122(1):73–80.PubMedCrossRef
60.
Zurück zum Zitat Rubia K, Alegria A, Brinson H. Imaging the ADHD brain: disorder-specificity, medication effects and clinical translation. Expert Rev Neurother. 2014;14(5):519–38.PubMedCrossRef Rubia K, Alegria A, Brinson H. Imaging the ADHD brain: disorder-specificity, medication effects and clinical translation. Expert Rev Neurother. 2014;14(5):519–38.PubMedCrossRef
61.
Zurück zum Zitat Cortese S, Kelly C, Chabernaud C, Proal E, et al. Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies. Am J Psychiatry. 2012;169(10):1038–55.PubMedCrossRef Cortese S, Kelly C, Chabernaud C, Proal E, et al. Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies. Am J Psychiatry. 2012;169(10):1038–55.PubMedCrossRef
62.
Zurück zum Zitat Arnsten AF, Rubia K. Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders. J Am Acad Child Adolesc Psychiatry. 2012;51(4):356–67.PubMedCrossRef Arnsten AF, Rubia K. Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders. J Am Acad Child Adolesc Psychiatry. 2012;51(4):356–67.PubMedCrossRef
63.
Zurück zum Zitat Arnsten AF. Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways. J Clin Psychiatry. 2006;67 Suppl 8:7–12.PubMed Arnsten AF. Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways. J Clin Psychiatry. 2006;67 Suppl 8:7–12.PubMed
64.
Zurück zum Zitat Bush G. Cingulate, frontal, and parietal cortical dysfunction in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2011;69(12):1160–7.PubMedCrossRefPubMedCentral Bush G. Cingulate, frontal, and parietal cortical dysfunction in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2011;69(12):1160–7.PubMedCrossRefPubMedCentral
66.
Zurück zum Zitat Casey BJ, Riddle M. Typical and atypical development of attention. In: Posner M, editor. Cognitive neuroscience of attention. New York: Guilford Press; 2012. p. 514. Casey BJ, Riddle M. Typical and atypical development of attention. In: Posner M, editor. Cognitive neuroscience of attention. New York: Guilford Press; 2012. p. 514.
67.
Zurück zum Zitat Konrad K, Eickhoff SB. Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder. Hum Brain Mapp. 2010;31(6):904–16.PubMedCrossRef Konrad K, Eickhoff SB. Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder. Hum Brain Mapp. 2010;31(6):904–16.PubMedCrossRef
68.
Zurück zum Zitat Castellanos FX, Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci. 2002;3(8):617–28.PubMed Castellanos FX, Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci. 2002;3(8):617–28.PubMed
69.
Zurück zum Zitat Fair DA, Nigg JT, Iyer S, Bathula D, et al. Distinct neural signatures detected for ADHD subtypes after controlling for micro-movements in resting state functional connectivity MRI data. Front Syst Neurosci. 2012;6:80.PubMedPubMedCentral Fair DA, Nigg JT, Iyer S, Bathula D, et al. Distinct neural signatures detected for ADHD subtypes after controlling for micro-movements in resting state functional connectivity MRI data. Front Syst Neurosci. 2012;6:80.PubMedPubMedCentral
70.
Zurück zum Zitat Helps SK, James C, Debener S, Karl A, Sonuga-Barke EJS. Very low frequency EEG oscillations and the resting brain in young adults: a preliminary study of localisation, stability and association with symptoms of inattention. J Neural Transm. 2008;115(2):279–85.PubMedCrossRef Helps SK, James C, Debener S, Karl A, Sonuga-Barke EJS. Very low frequency EEG oscillations and the resting brain in young adults: a preliminary study of localisation, stability and association with symptoms of inattention. J Neural Transm. 2008;115(2):279–85.PubMedCrossRef
71.
Zurück zum Zitat Castellanos FX, Margulies DS, Kelly C, Uddin LQ, et al. Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63(3):332–7.PubMedCrossRefPubMedCentral Castellanos FX, Margulies DS, Kelly C, Uddin LQ, et al. Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63(3):332–7.PubMedCrossRefPubMedCentral
72.
Zurück zum Zitat Helps SK, Broyd SJ, James CJ, Karl A, Sonuga-Barke EJS. The attenuation of very low frequency brain oscillations in transitions from a rest state to active attention. J Psychophysiol. 2009;23(4):191–8.CrossRef Helps SK, Broyd SJ, James CJ, Karl A, Sonuga-Barke EJS. The attenuation of very low frequency brain oscillations in transitions from a rest state to active attention. J Psychophysiol. 2009;23(4):191–8.CrossRef
73.
Zurück zum Zitat Broyd SJ, Demanuele C, Debener S, Helps SK, et al. Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev. 2009;33(3):279–96.PubMedCrossRef Broyd SJ, Demanuele C, Debener S, Helps SK, et al. Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev. 2009;33(3):279–96.PubMedCrossRef
74.
Zurück zum Zitat Helps SK, Broyd SJ, James CJ, Karl A, et al. Altered spontaneous low frequency brain activity in attention deficit/hyperactivity disorder. Brain Res. 2010;1322:134–43.PubMedCrossRef Helps SK, Broyd SJ, James CJ, Karl A, et al. Altered spontaneous low frequency brain activity in attention deficit/hyperactivity disorder. Brain Res. 2010;1322:134–43.PubMedCrossRef
75.•
Zurück zum Zitat Lenartowicz A, Delorme A, Walshaw PD, Cho AL, et al. Electroencephalography correlates of spatial working memory deficits in attention-deficit/hyperactivity disorder: vigilance, encoding, and maintenance. J Neurosci. 2014;34(4):1171–82. One of the first comprehensive assays of event-related spectral profiles in ADHD, combining spectral, event-related, independent component and source imaging analyses.PubMedCrossRefPubMedCentral Lenartowicz A, Delorme A, Walshaw PD, Cho AL, et al. Electroencephalography correlates of spatial working memory deficits in attention-deficit/hyperactivity disorder: vigilance, encoding, and maintenance. J Neurosci. 2014;34(4):1171–82. One of the first comprehensive assays of event-related spectral profiles in ADHD, combining spectral, event-related, independent component and source imaging analyses.PubMedCrossRefPubMedCentral
76.
Zurück zum Zitat Mazaheri A, Coffey-Corina S, Mangun GR, Bekker EM, et al. Functional disconnection of frontal cortex and visual cortex in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;67(7):617–23.PubMedCrossRef Mazaheri A, Coffey-Corina S, Mangun GR, Bekker EM, et al. Functional disconnection of frontal cortex and visual cortex in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;67(7):617–23.PubMedCrossRef
77.
Zurück zum Zitat Karch S, Thalmeier T, Lutz J, Cerovecki A, et al. Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients. Eur Arch Psychiatry Clin Neurosci. 2010;260(5):427–40.PubMedCrossRef Karch S, Thalmeier T, Lutz J, Cerovecki A, et al. Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients. Eur Arch Psychiatry Clin Neurosci. 2010;260(5):427–40.PubMedCrossRef
79.
Zurück zum Zitat Yan WX, Mullinger KJ, Brookes MJ, Bowtell R. Understanding gradient artefacts in simultaneous EEG/fMRI. Neuroimage. 2009;46(2):459–71.PubMedCrossRef Yan WX, Mullinger KJ, Brookes MJ, Bowtell R. Understanding gradient artefacts in simultaneous EEG/fMRI. Neuroimage. 2009;46(2):459–71.PubMedCrossRef
80.
Zurück zum Zitat Mullinger KJ, Havenhand J, Bowtell R. Identifying the sources of the pulse artefact in EEG recordings made inside an MR scanner. Neuroimage. 2013;71:75–83.PubMedCrossRefPubMedCentral Mullinger KJ, Havenhand J, Bowtell R. Identifying the sources of the pulse artefact in EEG recordings made inside an MR scanner. Neuroimage. 2013;71:75–83.PubMedCrossRefPubMedCentral
81.
Zurück zum Zitat Debener S, Mullinger KJ, Niazy RK, Bowtell RW. Properties of the ballistocardiogram artefact as revealed by EEG recordings at 1.5, 3 and 7 T static magnetic field strength. Int J Psychophysiol. 2008;67(3):189–99.PubMedCrossRef Debener S, Mullinger KJ, Niazy RK, Bowtell RW. Properties of the ballistocardiogram artefact as revealed by EEG recordings at 1.5, 3 and 7 T static magnetic field strength. Int J Psychophysiol. 2008;67(3):189–99.PubMedCrossRef
82.
Zurück zum Zitat Chowdhury ME, Mullinger KJ, Glover P, Bowtell R. Reference layer artefact subtraction (RLAS): a novel method of minimizing EEG artefacts during simultaneous fMRI. Neuroimage. 2014;84:307–19.PubMedCrossRef Chowdhury ME, Mullinger KJ, Glover P, Bowtell R. Reference layer artefact subtraction (RLAS): a novel method of minimizing EEG artefacts during simultaneous fMRI. Neuroimage. 2014;84:307–19.PubMedCrossRef
83.•
Zurück zum Zitat Mullinger KJ, Castellone P, Bowtell R. Best current practice for obtaining high quality EEG data during simultaneous FMRI. J Vis Exp. 2013(76). Valuable, detailed guide to concurrent EEG-fMRI methodology. Mullinger KJ, Castellone P, Bowtell R. Best current practice for obtaining high quality EEG data during simultaneous FMRI. J Vis Exp. 2013(76). Valuable, detailed guide to concurrent EEG-fMRI methodology.
84.
Zurück zum Zitat LeVan P, Maclaren J, Herbst M, Sostheim R, et al. Ballistocardiographic artifact removal from simultaneous EEG-fMRI using an optical motion-tracking system. Neuroimage. 2013;75:1–11.PubMedCrossRef LeVan P, Maclaren J, Herbst M, Sostheim R, et al. Ballistocardiographic artifact removal from simultaneous EEG-fMRI using an optical motion-tracking system. Neuroimage. 2013;75:1–11.PubMedCrossRef
85.
Zurück zum Zitat de Munck JC, van Houdt PJ, Goncalves SI, van Wegen E, Ossenblok PP. Novel artefact removal algorithms for co-registered EEG/fMRI based on selective averaging and subtraction. Neuroimage. 2013;64:407–15.PubMedCrossRef de Munck JC, van Houdt PJ, Goncalves SI, van Wegen E, Ossenblok PP. Novel artefact removal algorithms for co-registered EEG/fMRI based on selective averaging and subtraction. Neuroimage. 2013;64:407–15.PubMedCrossRef
86.
Zurück zum Zitat Picton TW, Bentin S, Berg P, Donchin E, et al. Guidelines for using human event-related potentials to study cognition: recording standards and publication criteria. Psychophysiology. 2000;37(2):127–52.PubMedCrossRef Picton TW, Bentin S, Berg P, Donchin E, et al. Guidelines for using human event-related potentials to study cognition: recording standards and publication criteria. Psychophysiology. 2000;37(2):127–52.PubMedCrossRef
87.
Zurück zum Zitat Makeig S, Jung TP, Bell AJ, Ghahremani D, Sejnowski TJ. Blind separation of event-related brain response components. Psychophysiology. 1996;33:S58. Makeig S, Jung TP, Bell AJ, Ghahremani D, Sejnowski TJ. Blind separation of event-related brain response components. Psychophysiology. 1996;33:S58.
88.
Zurück zum Zitat Makeig S, AnlloVento L, Jung P, Bell AJ, et al. Independent component analysis of event-related potentials during a selective attention task. Psychophysiology. 1996;33:S58. Makeig S, AnlloVento L, Jung P, Bell AJ, et al. Independent component analysis of event-related potentials during a selective attention task. Psychophysiology. 1996;33:S58.
89.
Zurück zum Zitat Michel CM, Murray MM. Towards the utilization of EEG as a brain imaging tool. Neuroimage. 2012;61(2):371–85.PubMedCrossRef Michel CM, Murray MM. Towards the utilization of EEG as a brain imaging tool. Neuroimage. 2012;61(2):371–85.PubMedCrossRef
90.
Zurück zum Zitat Michel CM, Murray MM, Lantz G, Gonzalez S, et al. EEG source imaging. Clin Neurophysiol. 2004;115(10):2195–222.PubMedCrossRef Michel CM, Murray MM, Lantz G, Gonzalez S, et al. EEG source imaging. Clin Neurophysiol. 2004;115(10):2195–222.PubMedCrossRef
91.•
Zurück zum Zitat ADHD-200-Consortium. The ADHD-200 Consortium: a model to advance the translational potential of neuroimaging in clinical neuroscience. Front Syst Neurosci. 2012;6:62. Report of diagnostic results from the large-scale, multi-site, multivariate competition analyses of over 700 MRI datasets of children with and without ADHD. ADHD-200-Consortium. The ADHD-200 Consortium: a model to advance the translational potential of neuroimaging in clinical neuroscience. Front Syst Neurosci. 2012;6:62. Report of diagnostic results from the large-scale, multi-site, multivariate competition analyses of over 700 MRI datasets of children with and without ADHD.
Metadaten
Titel
Use of EEG to Diagnose ADHD
verfasst von
Agatha Lenartowicz
Sandra K. Loo
Publikationsdatum
01.11.2014
Verlag
Springer US
Erschienen in
Current Psychiatry Reports / Ausgabe 11/2014
Print ISSN: 1523-3812
Elektronische ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-014-0498-0

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