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Current Rheumatology Reports

Erschienen in:

01.09.2013 | SERONEGATIVE ARTHRITIS (MA KHAN, SECTION EDITOR)

Treatment Challenges in Axial Spondylarthritis and Future Directions

verfasst von: Joachim Sieper

Erschienen in: Current Rheumatology Reports | Ausgabe 9/2013

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Abstract

Major progress has been made in recent years in the management of axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA). Most predictors of response have been defined for TNF-blocker therapy, and new treatment strategies are being discussed about how to best reach remission and how to maintain remission. Other biologics besides TNF-blockers have been tested in AS but have so far failed. The IL-17/IL-23 cytokines currently seem to be the most interesting targets. Short-term TNF-blocker therapy does not inhibit radiographic progression but long-term might do so. NSAIDs have been proven to inhibit such progression, even after 2 years of treatment. The effect of a combined therapy of NSAIDs with TNF-blockers on the inhibition of new bone formation in AS patients is currently unknown.

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51.

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Titel: Treatment Challenges in Axial Spondylarthritis and Future Directions
verfasst von: Joachim Sieper
Publikationsdatum: 01.09.2013
Verlag: Springer US
Erschienen in: Current Rheumatology Reports / Ausgabe 9/2013
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-013-0356-9

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