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Erschienen in: Current Rheumatology Reports 4/2015

01.04.2015 | Vasculitis (LR Espinoza, Section Editor)

Cogan’s Syndrome and Other Ocular Vasculitides

verfasst von: Gabriela M. Espinoza, Angela Prost

Erschienen in: Current Rheumatology Reports | Ausgabe 4/2015

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Abstract

The clinical presentation of Cogan’s syndrome has been classified as typical and atypical. Like other forms of ocular vasculitis, Cogan’s syndrome has been found to have autoimmune origins with antibodies against the cornea, inner ear, and endothelial antigens. Antineutrophil cytoplasmic antibody (ANCA) and rheumatoid factor (RF) have been associated with Cogan’s syndrome as well as ocular-involving vasculitides not as strongly associated with the audiovestibular manifestations such as granulomatosis with polyangiitis and rheumatoid arthritis. The mainstay of therapy has been corticosteroids although other methods have been described in recalcitrant disease and to prevent development of systemic sequelae.
Literatur
1.
Zurück zum Zitat Cogan DG. Syndrome of non-syphilitic interstitial keratitis and vestibuloauditory symptoms. Arch Ophthalmol. 1945;33:144–9.CrossRef Cogan DG. Syndrome of non-syphilitic interstitial keratitis and vestibuloauditory symptoms. Arch Ophthalmol. 1945;33:144–9.CrossRef
2.
Zurück zum Zitat Haynes BF, Kaiser-Kupfer MI, Mason P, Fauci AS. Cogan syndrome: studies in thirteen patients, long-term follow-up, and a review of the literature. Medicine. 1980;59:426–41.CrossRefPubMed Haynes BF, Kaiser-Kupfer MI, Mason P, Fauci AS. Cogan syndrome: studies in thirteen patients, long-term follow-up, and a review of the literature. Medicine. 1980;59:426–41.CrossRefPubMed
3.
Zurück zum Zitat Vollersten R. Vasculitis and Cogan’s syndrome. Rheum Dis Clin N Am. 1990;16:433–8. Vollersten R. Vasculitis and Cogan’s syndrome. Rheum Dis Clin N Am. 1990;16:433–8.
4.
Zurück zum Zitat Lunardi C, Bason C, Leandri M, et al. Autoantibodies to inner ear and endothelial antigens in Cogan’s syndrome. Lancet. 2002;360:915–21.CrossRefPubMed Lunardi C, Bason C, Leandri M, et al. Autoantibodies to inner ear and endothelial antigens in Cogan’s syndrome. Lancet. 2002;360:915–21.CrossRefPubMed
5.
Zurück zum Zitat Van Doornum S, McColl G, Walter M, et al. Prolonged prodrome, systemic vasculitis, and deafness in Cogan’s syndrome. Ann Rheum Dis. 2001;60:69–71.CrossRefPubMedCentralPubMed Van Doornum S, McColl G, Walter M, et al. Prolonged prodrome, systemic vasculitis, and deafness in Cogan’s syndrome. Ann Rheum Dis. 2001;60:69–71.CrossRefPubMedCentralPubMed
6.
Zurück zum Zitat Cheson BD, Bluming AZ, Alroy J. Cogan’s syndrome: a systemic vasculitis. Am J Med. 1976;60:549–55.CrossRefPubMed Cheson BD, Bluming AZ, Alroy J. Cogan’s syndrome: a systemic vasculitis. Am J Med. 1976;60:549–55.CrossRefPubMed
7.
Zurück zum Zitat Grasland A, Pouchot J, Hachulla E, et al. Typical and atypical Cogan’s syndrome: 32 cases and review of the literature. Rheumatology. 2004;43:1007–15.CrossRefPubMed Grasland A, Pouchot J, Hachulla E, et al. Typical and atypical Cogan’s syndrome: 32 cases and review of the literature. Rheumatology. 2004;43:1007–15.CrossRefPubMed
8.
Zurück zum Zitat Branislava I, Marijana T, Nemanja D, et al. Atypical Cogan’s syndrome associated with coronary disease. Chin Med J. 2011;124:3192–4.PubMed Branislava I, Marijana T, Nemanja D, et al. Atypical Cogan’s syndrome associated with coronary disease. Chin Med J. 2011;124:3192–4.PubMed
9.
Zurück zum Zitat Gaubitz M, Lubben B, Seidel M, et al. Cogan’s syndrome: Organ-specific autoimmune disease or systemic vasculitis? A report of two cases and review of the literature. Clin Exp Rheumatol. 2001;19:463–9.PubMed Gaubitz M, Lubben B, Seidel M, et al. Cogan’s syndrome: Organ-specific autoimmune disease or systemic vasculitis? A report of two cases and review of the literature. Clin Exp Rheumatol. 2001;19:463–9.PubMed
10.
Zurück zum Zitat Gasparovic H, Djuric Z, Bosnic D, et al. Aortic root vasculitis associated with Cogan’s syndrome. Ann Thorac Surg. 2011;92:340–1.CrossRefPubMed Gasparovic H, Djuric Z, Bosnic D, et al. Aortic root vasculitis associated with Cogan’s syndrome. Ann Thorac Surg. 2011;92:340–1.CrossRefPubMed
11.
Zurück zum Zitat Hautefort C, Loundon N, Montchilova M, et al. Mycophenolate mofetil as a treatment of steroid dependent Cogan’s syndrome in childhood. Int J Pediatr Otorhinolaryngol. 2009;73:1477–9.CrossRefPubMed Hautefort C, Loundon N, Montchilova M, et al. Mycophenolate mofetil as a treatment of steroid dependent Cogan’s syndrome in childhood. Int J Pediatr Otorhinolaryngol. 2009;73:1477–9.CrossRefPubMed
12.
Zurück zum Zitat Lepur D, Vranjican Z, Himbele J, et al. Chlamydia pneumonia infection as a trigger for a Cogan’s syndrome. J Infect. 2006;52:223–6.CrossRefPubMed Lepur D, Vranjican Z, Himbele J, et al. Chlamydia pneumonia infection as a trigger for a Cogan’s syndrome. J Infect. 2006;52:223–6.CrossRefPubMed
13.•
Zurück zum Zitat Pagnini I, Zannin ME, Vittadello F, et al. Clinical features and outcome of Cogan Syndrome. J Pediatr. 2012;160:303–7. Review of the pediatric implications of Cogan syndrome with focus on different manifestations in children with major impact on function.CrossRefPubMed Pagnini I, Zannin ME, Vittadello F, et al. Clinical features and outcome of Cogan Syndrome. J Pediatr. 2012;160:303–7. Review of the pediatric implications of Cogan syndrome with focus on different manifestations in children with major impact on function.CrossRefPubMed
14.
Zurück zum Zitat Gluth MB, Baratz KH, Matteson EL, Driscoll CL. Cogan syndrome: a retrospective review of 60 patients throughout a half century. Mayo Clin Proc. 2006;81:483–8.CrossRefPubMed Gluth MB, Baratz KH, Matteson EL, Driscoll CL. Cogan syndrome: a retrospective review of 60 patients throughout a half century. Mayo Clin Proc. 2006;81:483–8.CrossRefPubMed
15.
Zurück zum Zitat Darougar S, John AC, Viswalingam M, et al. Isolation of Chlamydia psittaci from a patient with interstitial keratitis and uveitis associated with ontological and cardiovascular lesions. Br J Ophthalmol. 1978;62:709–14.CrossRefPubMedCentralPubMed Darougar S, John AC, Viswalingam M, et al. Isolation of Chlamydia psittaci from a patient with interstitial keratitis and uveitis associated with ontological and cardiovascular lesions. Br J Ophthalmol. 1978;62:709–14.CrossRefPubMedCentralPubMed
16.
Zurück zum Zitat Ljungstrom L, Franzen C, Schlaug M, et al. Reinfection with Chlamydia pneumonia may induce isolated and systemic vasculitis in small and large vessels. Scand J Infect Dis Suppl. 1997;104:37–40.PubMed Ljungstrom L, Franzen C, Schlaug M, et al. Reinfection with Chlamydia pneumonia may induce isolated and systemic vasculitis in small and large vessels. Scand J Infect Dis Suppl. 1997;104:37–40.PubMed
17.
Zurück zum Zitat Laitinen K, Laurila A, Pyhala L, Leinonen M, Saikku P. Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits. Infect Immun. 1997;65:4832–5.PubMedCentralPubMed Laitinen K, Laurila A, Pyhala L, Leinonen M, Saikku P. Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits. Infect Immun. 1997;65:4832–5.PubMedCentralPubMed
18.
Zurück zum Zitat Helmchen C, Arbusow V, Jager L, et al. Cogan’s syndrome: clinical significance of antibodies against the inner ear and cornea. Acta Otolaryngol (Stockh). 1999;119:528–36.CrossRef Helmchen C, Arbusow V, Jager L, et al. Cogan’s syndrome: clinical significance of antibodies against the inner ear and cornea. Acta Otolaryngol (Stockh). 1999;119:528–36.CrossRef
19.
Zurück zum Zitat Hughes GB, Kinney SE, Barna BP, et al. Autoimmune reactivity in Cogan’s syndrome: a preliminary report. Otolaryngol Head Neck Surg. 1983;91:24–32.PubMed Hughes GB, Kinney SE, Barna BP, et al. Autoimmune reactivity in Cogan’s syndrome: a preliminary report. Otolaryngol Head Neck Surg. 1983;91:24–32.PubMed
20.
Zurück zum Zitat Majoor MH, Albers FW, van der Gaag R, et al. Corneal autoimmunity in Cogan’s syndrome? Report of two cases. Ann Otol Rhinol Laryngol. 1992;101:679–84.CrossRefPubMed Majoor MH, Albers FW, van der Gaag R, et al. Corneal autoimmunity in Cogan’s syndrome? Report of two cases. Ann Otol Rhinol Laryngol. 1992;101:679–84.CrossRefPubMed
21.
Zurück zum Zitat Garcia Callejo FJ, Costa Alcacer I, Blay Galaud L, et al. Inner ear autoimmune disorder. Cogan’s syndrome. An Esp Pediatr. 2001;55:87–91.CrossRefPubMed Garcia Callejo FJ, Costa Alcacer I, Blay Galaud L, et al. Inner ear autoimmune disorder. Cogan’s syndrome. An Esp Pediatr. 2001;55:87–91.CrossRefPubMed
22.•
Zurück zum Zitat Bonaguri C, Orsoni J, Russo A, et al. Cogan’s Syndrome: Anti-Hsp70 Antibodies are a serological marker in the typical form. IMAJ. 2014;16:285–8. Important autoantibody finding that may serve as a serological marker for typical Cogan’s syndrome.PubMed Bonaguri C, Orsoni J, Russo A, et al. Cogan’s Syndrome: Anti-Hsp70 Antibodies are a serological marker in the typical form. IMAJ. 2014;16:285–8. Important autoantibody finding that may serve as a serological marker for typical Cogan’s syndrome.PubMed
24.
Zurück zum Zitat Tarney CM, Wilson K, Sewell MF. Cogan Syndrome in pregnancy. Obstet Gynecol. 2014;124:428–31.CrossRefPubMed Tarney CM, Wilson K, Sewell MF. Cogan Syndrome in pregnancy. Obstet Gynecol. 2014;124:428–31.CrossRefPubMed
25.
Zurück zum Zitat Tervaert JW, Mulder L, Stegeman C, et al. Occurrence of autoantibodies to human leucocyte elastase in Wegener’s granulomatosis and other inflammatory disorders. Ann Rheum Dis. 1993;52:115–20.CrossRefPubMedCentral Tervaert JW, Mulder L, Stegeman C, et al. Occurrence of autoantibodies to human leucocyte elastase in Wegener’s granulomatosis and other inflammatory disorders. Ann Rheum Dis. 1993;52:115–20.CrossRefPubMedCentral
26.
Zurück zum Zitat Yamanishi Y, Ishioka S, Takeda M, et al. Atypical Cogan’s syndrome associated with antineutrophil cytoplasmic autoantibodies. Br J Rheumatol. 1996;35:601–3.CrossRef Yamanishi Y, Ishioka S, Takeda M, et al. Atypical Cogan’s syndrome associated with antineutrophil cytoplasmic autoantibodies. Br J Rheumatol. 1996;35:601–3.CrossRef
27.
Zurück zum Zitat Suzuki M, Arimura Y, Minoshima S, et al. A case of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA)-related glomerulonephritis associated with Cogan’s syndrome. Nippon Jinzo Gakkai Shi. 1996;38:423–7.PubMed Suzuki M, Arimura Y, Minoshima S, et al. A case of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA)-related glomerulonephritis associated with Cogan’s syndrome. Nippon Jinzo Gakkai Shi. 1996;38:423–7.PubMed
28.
Zurück zum Zitat Brijker F, Magee CC, Tervaert J, et al. Outcome analysis of patients with vasculitis associated with antineutrophil cytoplasmic antibodies. Clin Nephrol. 1999;52:344–51.PubMed Brijker F, Magee CC, Tervaert J, et al. Outcome analysis of patients with vasculitis associated with antineutrophil cytoplasmic antibodies. Clin Nephrol. 1999;52:344–51.PubMed
29.
Zurück zum Zitat Lee LY, Akhtar MM, Kirresh O, Gibson T: Interstitial keratitis and sensorineural hearing loss as a manifestation of rheumatoid arthritis: clinical lessons from a rare complication. BMJ Case Rep 2012. Lee LY, Akhtar MM, Kirresh O, Gibson T: Interstitial keratitis and sensorineural hearing loss as a manifestation of rheumatoid arthritis: clinical lessons from a rare complication. BMJ Case Rep 2012.
30.
Zurück zum Zitat Harper SL, Letko E, Samson CM, et al. Wegener’s Granulomatosis: the relationship between ocular and systemic disease. J Rheumatol. 2001;28:1025–32.PubMed Harper SL, Letko E, Samson CM, et al. Wegener’s Granulomatosis: the relationship between ocular and systemic disease. J Rheumatol. 2001;28:1025–32.PubMed
31.
Zurück zum Zitat Bakthavachalam S, Driver MS, Cox C, et al. Hearing loss in Wegener’s granulomatosis. Otol Neurotol. 2004;25:833–7.CrossRefPubMed Bakthavachalam S, Driver MS, Cox C, et al. Hearing loss in Wegener’s granulomatosis. Otol Neurotol. 2004;25:833–7.CrossRefPubMed
32.
Zurück zum Zitat Sriskandarajah V, Bansal RA, Yeoh R, Bansal AS. Early intervention in localized Wegener’s granulomatosis with sensorineural hearing loss preserves hearing. Am J Audiol. 2012;21:121–6.CrossRefPubMed Sriskandarajah V, Bansal RA, Yeoh R, Bansal AS. Early intervention in localized Wegener’s granulomatosis with sensorineural hearing loss preserves hearing. Am J Audiol. 2012;21:121–6.CrossRefPubMed
33.
Zurück zum Zitat Gran JT, Nordvag BY, Storesund B. An overlap syndrome with features of atypical Cogan syndrome and Wegener’s granulomatosis. Scand J Rheumatol. 1999;28:62–4.CrossRefPubMed Gran JT, Nordvag BY, Storesund B. An overlap syndrome with features of atypical Cogan syndrome and Wegener’s granulomatosis. Scand J Rheumatol. 1999;28:62–4.CrossRefPubMed
34.
Zurück zum Zitat Finkielman JD, Lee AS, Hummel AM, et al. ANCA are detectable in nearly all patients with active severe Wegener’s granulomatosis. Am J Med. 2007;120:643.e9–14.CrossRef Finkielman JD, Lee AS, Hummel AM, et al. ANCA are detectable in nearly all patients with active severe Wegener’s granulomatosis. Am J Med. 2007;120:643.e9–14.CrossRef
35.
Zurück zum Zitat Zlatanovic G, Veselinovic D, Cekic S, et al. Ocular manifestation of rheumatoid arthritis-different forms and frequency. Bosn J Basic Med Sci. 2010;10:323–7.PubMed Zlatanovic G, Veselinovic D, Cekic S, et al. Ocular manifestation of rheumatoid arthritis-different forms and frequency. Bosn J Basic Med Sci. 2010;10:323–7.PubMed
36.
Zurück zum Zitat Fujita M, Igarachi T, Kurai T, et al. Correlation between dry eye and rheumatoid arthritis activity. Am J Ophthalmol. 2005;140:808–13.CrossRefPubMed Fujita M, Igarachi T, Kurai T, et al. Correlation between dry eye and rheumatoid arthritis activity. Am J Ophthalmol. 2005;140:808–13.CrossRefPubMed
37.•
Zurück zum Zitat Knox Cartwright NE, Tole DM, Georgoudis P, Cook SD. Peripheral ulcerative keratitis and corneal melt: a 10-year single center review with historical comparison. Cornea. 2014;33:27–31. Important review showing that current therapeutic interventions are improving outcomes in immune mediated ocular disease.CrossRefPubMed Knox Cartwright NE, Tole DM, Georgoudis P, Cook SD. Peripheral ulcerative keratitis and corneal melt: a 10-year single center review with historical comparison. Cornea. 2014;33:27–31. Important review showing that current therapeutic interventions are improving outcomes in immune mediated ocular disease.CrossRefPubMed
38.
Zurück zum Zitat Takatsu M, Higaki M, Kinoshita H, et al. Ear involvement in patients with Rheumatoid Arthritis. Otol Neurotol. 2005;26:755–61.CrossRefPubMed Takatsu M, Higaki M, Kinoshita H, et al. Ear involvement in patients with Rheumatoid Arthritis. Otol Neurotol. 2005;26:755–61.CrossRefPubMed
39.
Zurück zum Zitat Pascual-Ramos V, Contreras-Yanez I, Enriquez L, et al. Hearing impairment in a tertiary-care-level population of Mexican rheumatoid arthritis patients. J Clin Rheumatol. 2012;18:393–8.CrossRef Pascual-Ramos V, Contreras-Yanez I, Enriquez L, et al. Hearing impairment in a tertiary-care-level population of Mexican rheumatoid arthritis patients. J Clin Rheumatol. 2012;18:393–8.CrossRef
40.
Zurück zum Zitat Pascual-Ramos V, Contreras-Yanez I, Rivera-Hoyos P, et al. Cumulative disease activity predicts incidental hearing impairment in patient with rheumatoid arthritis. Clin Rheumatol. 2014;33:315–21.CrossRefPubMed Pascual-Ramos V, Contreras-Yanez I, Rivera-Hoyos P, et al. Cumulative disease activity predicts incidental hearing impairment in patient with rheumatoid arthritis. Clin Rheumatol. 2014;33:315–21.CrossRefPubMed
41.
Zurück zum Zitat Deane KD. Preclinical rheumatoid arthritis (autoantibodies): an updated review. Curr Rheumatol Rep. 2014;16:419.CrossRefPubMed Deane KD. Preclinical rheumatoid arthritis (autoantibodies): an updated review. Curr Rheumatol Rep. 2014;16:419.CrossRefPubMed
42.•
Zurück zum Zitat Kessel A, Vadasz Z, Toubi E. Cogan syndrome—Pathogenesis, clinical variants and treatment approaches. Autoimmun Rev. 2014;13:351–4. A nice review of Cogan’s syndrome stressing more of the plethora of systemic findings associated with the disease.CrossRefPubMed Kessel A, Vadasz Z, Toubi E. Cogan syndrome—Pathogenesis, clinical variants and treatment approaches. Autoimmun Rev. 2014;13:351–4. A nice review of Cogan’s syndrome stressing more of the plethora of systemic findings associated with the disease.CrossRefPubMed
43.
Zurück zum Zitat Beccastrini E, Emmi G, Squatrito D, et al. Infliximab and Cogan’s syndrome. Clin Otolaryngol. 2010;35:441–2.CrossRefPubMed Beccastrini E, Emmi G, Squatrito D, et al. Infliximab and Cogan’s syndrome. Clin Otolaryngol. 2010;35:441–2.CrossRefPubMed
44.
Zurück zum Zitat Shahid FL, Mukherjee R, Knapp C. Cogan’s Syndrome associated with orbital inflammation. Orbit. 2013;32:206–7.CrossRefPubMed Shahid FL, Mukherjee R, Knapp C. Cogan’s Syndrome associated with orbital inflammation. Orbit. 2013;32:206–7.CrossRefPubMed
45.
Zurück zum Zitat Shibuya M, Fijio K, Morita K, et al. Successful treatment with tocilizumab in a case of Cogan’s syndrome complicated with aortitis. Mod Rheumatol. 2013;23:577–81.CrossRefPubMed Shibuya M, Fijio K, Morita K, et al. Successful treatment with tocilizumab in a case of Cogan’s syndrome complicated with aortitis. Mod Rheumatol. 2013;23:577–81.CrossRefPubMed
46.
Zurück zum Zitat Bovo R, Ciorba A, Trevisi P, et al. Cochlear implant in Cogan syndrome. Acta Otolaryngol (Stockh). 2011;131:494–7.CrossRef Bovo R, Ciorba A, Trevisi P, et al. Cochlear implant in Cogan syndrome. Acta Otolaryngol (Stockh). 2011;131:494–7.CrossRef
Metadaten
Titel
Cogan’s Syndrome and Other Ocular Vasculitides
verfasst von
Gabriela M. Espinoza
Angela Prost
Publikationsdatum
01.04.2015
Verlag
Springer US
Erschienen in
Current Rheumatology Reports / Ausgabe 4/2015
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-015-0499-y

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