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Current Rheumatology Reports

Erschienen in:

01.12.2020 | Recent Advances in Large Vessel Vasculitis ( C Dejaco and C Duftner, Section Editors)

Treatment of Giant Cell Arteritis and Takayasu Arteritis—Current and Future

verfasst von: B. Hellmich, A. F. Águeda, S. Monti, R. Luqmani

Erschienen in: Current Rheumatology Reports | Ausgabe 12/2020

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Abstract

Purpose of Review

Guidelines for the management of large vessel vasculitides have been recently updated by several scientific societies. We have evaluated the current recommendations for treatment of giant cell arteritis (GCA) and Takayasu arteritis (TA) and addressed potential future therapeutic strategies.

Recent Findings

While glucocorticoids (GCs) remain the gold standard for induction of remission, many patients relapse and acquire high cumulative GC exposure. Thus, GC-sparing therapies such as methotrexate are recommended for selected patients with GCA and all patients with TA. Recent high-quality evidence shows that tocilizumab is an effective GC-sparing agent in GCA. Non-biologic and biologic immunomodulators also appear to have GC-sparing properties in TA.

Summary

Tocilizumab is now considered to be part of the standard treatment for GCA, particularly with relapsing disease, but questions on its use such as length of treatment and monitoring of disease activity remain open. High-quality evidence to guide treatment of TA is still lacking.

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Titel: Treatment of Giant Cell Arteritis and Takayasu Arteritis—Current and Future
verfasst von: B. Hellmich
A. F. Águeda
S. Monti
R. Luqmani
Publikationsdatum: 01.12.2020
Verlag: Springer US
Erschienen in: Current Rheumatology Reports / Ausgabe 12/2020
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-020-00964-x

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Update Innere Medizin