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Clinical Orthopaedics and Related Research®

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01.02.2012 | Symposium: Papers Presented at the Annual Meetings of The Hip Society

The Otto Aufranc Award: Demineralized Bone Matrix Around Porous Implants Promotes Rapid Gap Healing and Bone Ingrowth

verfasst von: Letitia Lim, MD, J. Dennis Bobyn, PhD, Kristian M. Bobyn, BA, Louis-Philippe Lefebvre, MEng, Michael Tanzer, MD

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 2/2012

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Abstract

Background

Noncemented revision arthroplasty is often complicated by the presence of bone implant gaps that reduce initial stability and biologic fixation. Demineralized bone matrix has osteoinductive properties and therefore the potential to enhance gap healing and porous implant fixation.

Questions/purposes

We determined at what times and to what extent demineralized bone matrix promotes gap healing and bone ingrowth around a porous implant.

Methods

We inserted porous titanium implants into the proximal metaphyses of canine femora and humeri, with an initial 3-mm gap between host cancellous bone and implants. We left the gaps empty (control; n = 12) or filled them with either demineralized bone matrix (n = 6) or devitalized demineralized bone matrix (negative control; n = 6) and left them in situ for 4 or 12 weeks. We quantified volume healing of the gap with new bone using three-dimensional micro-CT scanning and quantified apposition and ingrowth using backscattered scanning electron microscopy.

Results

The density of bone inside gaps filled with demineralized bone matrix reached 64% and 93% of surrounding bone density by 4 and 12 weeks, respectively. Compared with empty controls and negative controls at 4 and 12 weeks, gap healing using demineralized bone matrix was two to three times greater and bone ingrowth and apposition were up to 15 times greater.

Conclusions

Demineralized bone matrix promotes rapid bone ingrowth and gap healing around porous implants.

Clinical Relevance

Demineralized bone matrix has potential for enhancing implant fixation in revision arthroplasty.

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Titel: The Otto Aufranc Award: Demineralized Bone Matrix Around Porous Implants Promotes Rapid Gap Healing and Bone Ingrowth
verfasst von: Letitia Lim, MD
J. Dennis Bobyn, PhD
Kristian M. Bobyn, BA
Louis-Philippe Lefebvre, MEng
Michael Tanzer, MD
Publikationsdatum: 01.02.2012
Verlag: Springer-Verlag
Erschienen in: Clinical Orthopaedics and Related Research® / Ausgabe 2/2012
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-011-2011-y

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The Otto Aufranc Award: Demineralized Bone Matrix Around Porous Implants Promotes Rapid Gap Healing and Bone Ingrowth

Abstract

Background

Questions/purposes

Methods

Results

Conclusions

Clinical Relevance

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Springer Medizin

Abstract

Background

Questions/purposes

Methods

Results

Conclusions

Clinical Relevance

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