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Preventive Effects of Zinc Against Psychological Stress-Induced Iron Dyshomeostasis, Erythropoiesis Inhibition, and Oxidative Stress Status in Rats

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Abstract

Psychological stress (PS) could cause decreased iron absorption and iron redistribution in body resulting in low iron concentration in the bone marrow and inhibition of erythropoiesis. In the present study, we investigated the effect of zinc supplementation on the iron metabolism, erythropoiesis, and oxidative stress status in PS-induced rats. Thirty-two rats were divided into two groups randomly: control group and zinc supplementation group. Each group was subdivided into two subgroups: control group and PS group. Rats received zinc supplementation before PS exposure established by a communication box. We investigated the serum corticosterone (CORT) level; iron apparent absorption; iron contents in liver, spleen, cortex, hippocampus, striatum, and serum; hematological parameters; malondialdehyde (MDA); reduced glutathione (GSH); and superoxide dismutase (SOD). Compared to PS-treated rats with normal diet, the PS-treated rats with zinc supplementation showed increased iron apparent absorption, serum iron, hemoglobin, red blood cell, GSH, and SOD activities; while the serum CORT; iron contents in liver, spleen, and regional brain; and MDA decreased. These results indicated that dietary zinc supplementation had preventive effects against PS-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats.

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Acknowledgments

This work was supported in part by the grants from National Natural Science Foundation of China (no. 30872120, 81001243), Natural Science Foundation of Shanghai (no.10ZR1437400) and Shanghai Health Bureau (nos. 08GWD23, 08GWQ012).

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Authors and Affiliations

  1. Department of Military Hygiene, Second Military Medical University, No. 800 Xiangyin Road, Shanghai, 200433, China

    Yingjie Li, Xinmin Chen, Zhilei Shen, Liping Tao, Hongxia Li, Haihong Qin, Min Li & Hui Shen

  2. Department of Immunology, Second Military Medical University, No. 800 Xiangyin Road, Shanghai, 200433, China

    Yuanyuan Zheng

  3. Department of Medical Oncology, Changzheng Hospital, No. 64 Hetian Road, Shanghai, 200070, China

    Jianxin Qian

Authors
  1. Yingjie Li
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  2. Yuanyuan Zheng
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  3. Jianxin Qian
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  4. Xinmin Chen
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  5. Zhilei Shen
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  6. Liping Tao
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  7. Hongxia Li
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  8. Haihong Qin
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  9. Min Li
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  10. Hui Shen
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Corresponding authors

Correspondence to Min Li or Hui Shen.

Additional information

Yingjie Li, Yuanyuan Zheng, and Jianxin Qian contributed equally to this work

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Li, Y., Zheng, Y., Qian, J. et al. Preventive Effects of Zinc Against Psychological Stress-Induced Iron Dyshomeostasis, Erythropoiesis Inhibition, and Oxidative Stress Status in Rats. Biol Trace Elem Res 147, 285–291 (2012). https://doi.org/10.1007/s12011-011-9319-z

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  • DOI: https://doi.org/10.1007/s12011-011-9319-z

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