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Risk Factors for Diabetes Mellitus in Women with Primary Ovarian Insufficiency

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Abstract

Primary ovarian insufficiency (POI) is not only a gynecological problem but also has serious effects on women’s health such as changes in hormone levels that can trigger fluctuations in blood sugar level and inflammation status. The present study was designed to determine vitamin D, copper, zinc, metabolic parameters [insulin, homeostasis model of assessment-insulin resistance (HOMA-IR)], inflammation parameters such as procalcitonin and high sensitivity C reactive protein (hs-CRP), and lipid profile in POI patients and control subjects with normal menstrual cycles. A total of 43 patients with nondiabetic POI were studied in order to evaluate and compare the findings with those of the control group, which comprised 33 women with normal menstrual cycles. The women with POI had higher levels of serum copper, serum insulin, glucose, LDL-cholesterol, total cholesterol, HOMA-IR, hs-CRP, and procalcitonin, whereas serum vitamin D and zinc levels were lower compared with the healthy control group. Follicle-stimulating hormone (FSH) levels were positively correlated with insulin, glucose, HOMA-IR, hs-CRP, procalcitonin, and copper and negatively correlated with vitamin D and zinc levels. In multivariate statistic analyses with body mass index and FSH as dependent variables, FSH was positively associated with copper and HOMA-IR negatively with vitamin D levels. The present study demonstrated that women with POI have traditional risk factors for diabetes mellitus, including lower levels of vitamin D, whereas higher levels of copper and HOMA-IR.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Meram School of Medicine, Konya University, Konya, Turkey

    Mustafa Kulaksizoglu & Mustafa Sait Gonen

  2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Selcuk University, Konya, Turkey

    Suleyman Hilmi Ipekci, Levent Kebapcilar, Huseyin Korkmaz & Suleyman Baldane

  3. Clinic of Obstetrics and Gynecology, Beyhekim State Hospital, Konya, Turkey

    Ayse Gul Kebapcilar

  4. Department of Biochemistry, Selcuk University, Konya, Turkey

    Fikret Akyurek

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  1. Mustafa Kulaksizoglu
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Correspondence to Levent Kebapcilar.

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Kulaksizoglu, M., Ipekci, S.H., Kebapcilar, L. et al. Risk Factors for Diabetes Mellitus in Women with Primary Ovarian Insufficiency. Biol Trace Elem Res 154, 313–320 (2013). https://doi.org/10.1007/s12011-013-9738-0

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  • DOI: https://doi.org/10.1007/s12011-013-9738-0

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