Skip to main content
Erschienen in: Cardiovascular Toxicology 5/2019

08.04.2019

Toxic Effects of Particulate Matter Derived from Dust Samples Near the Dzhidinski Ore Processing Mill, Eastern Siberia, Russia

verfasst von: Katherine E. Zychowski, Abigail Wheeler, Bethany Sanchez, Molly Harmon, Christina R. Steadman Tyler, Guy Herbert, Selita N. Lucas, Abdul-Mehdi Ali, Sumant Avasarala, Nitesh Kunda, Paul Robinson, Pavan Muttil, Jose M. Cerrato, Barry Bleske, Olga Smirnova, Matthew J. Campen

Erschienen in: Cardiovascular Toxicology | Ausgabe 5/2019

Einloggen, um Zugang zu erhalten

Abstract

Ambient particulate matter (PM) is associated with increased mortality and morbidity, an effect influenced by the metal components of the PM. We characterized five sediment samples obtained near a tungsten–molybdenum ore-processing complex in Zakamensk, Russia for elemental composition and PM toxicity with regard to pulmonary, vascular, and neurological outcomes. Elemental and trace metals analysis of complete sediment and PM10 (the respirable fraction, < 10 µm mass mean aerodynamic diameter) were performed using inductively coupled plasma optical emission spectrometry (ICP-OES) and mass spectrometry (ICP-MS). Sediment samples and PM10 consisted largely of silicon and iron and silicon and sodium, respectively. Trace metals including manganese and uranium in the complete sediment, as well as copper and lead in the PM10 were observed. Notably, metal concentrations were approximately 10 × higher in the PM10 than in the sediment. Exposure to 100 µg of PM10 via oropharyngeal aspiration in C56BL/6 mice resulted in pulmonary inflammation across all groups. In addition, mice exposed to three of the five PM10 samples exhibited impaired endothelial-dependent relaxation, and correlative analysis revealed associations between pulmonary inflammation and levels of lead and cadmium. A tendency for elevated cortical ccl2 and Tnf-α mRNA expression was induced by all samples and significant upregulation was noted following exposure to PM10 samples Z3 and Z4, respectively. Cortical Nqo1 mRNA levels were significantly upregulated in mice exposed to PM10 Z2. In conclusion, pulmonary exposure to PM samples from the Zakamensk region sediments induced varied pulmonary and systemic effects that may be influenced by elemental PM composition. Further investigation is needed to pinpoint putative drivers of neurological outcomes.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Aragon, M., Erdely, A., Bishop, L., Salmen, R., Weaver, J., Liu, J., Hall, P., Eye, T., Kodali, V., & Zeidler-Erdely, P. (2016). MMP-9-dependent serum-borne bioactivity caused by multiwalled carbon nanotube exposure induces vascular dysfunction via the CD36 scavenger receptor. Toxicological Sciences, 150, 488–498.CrossRefPubMedPubMedCentral Aragon, M., Erdely, A., Bishop, L., Salmen, R., Weaver, J., Liu, J., Hall, P., Eye, T., Kodali, V., & Zeidler-Erdely, P. (2016). MMP-9-dependent serum-borne bioactivity caused by multiwalled carbon nanotube exposure induces vascular dysfunction via the CD36 scavenger receptor. Toxicological Sciences, 150, 488–498.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Aragon, M. J., Chrobak, I., Brower, J., Roldan, L., Fredenburgh, L. E., McDonald, J. D., & Campen, M. J. (2015). Inflammatory and vasoactive effects of serum following inhalation of varied complex mixtures. Cardiovascular Toxicology, 16(2), 1–9. Aragon, M. J., Chrobak, I., Brower, J., Roldan, L., Fredenburgh, L. E., McDonald, J. D., & Campen, M. J. (2015). Inflammatory and vasoactive effects of serum following inhalation of varied complex mixtures. Cardiovascular Toxicology, 16(2), 1–9.
3.
Zurück zum Zitat Aragon, M. J., Topper, L., Tyler, C. R., Sanchez, B., Zychowski, K., Young, T., Herbert, G., Hall, P., Erdely, A., & Eye, T. 2017. Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood–brain barrier impairment. Proceedings of the National Academy of Sciences United States of America, 114, E1968–E1976.CrossRef Aragon, M. J., Topper, L., Tyler, C. R., Sanchez, B., Zychowski, K., Young, T., Herbert, G., Hall, P., Erdely, A., & Eye, T. 2017. Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood–brain barrier impairment. Proceedings of the National Academy of Sciences United States of America, 114, E1968–E1976.CrossRef
4.
Zurück zum Zitat Bajpai, R., Waseem, M., & Kaw, J. L. (1993). Pulmonary response to cadmium and nickel coated fly ash. Journal of Environmental Pathology, Toxicology and Oncology, 13, 251–257. Bajpai, R., Waseem, M., & Kaw, J. L. (1993). Pulmonary response to cadmium and nickel coated fly ash. Journal of Environmental Pathology, Toxicology and Oncology, 13, 251–257.
5.
Zurück zum Zitat Bell, M. L., Ebisu, K., Peng, R. D., Samet, J. M., & Dominici, F. (2009). Hospital admissions and chemical composition of fine particle air pollution. American Journal of Respiratory and Critical Care Medicine, 179, 1115–1120.CrossRefPubMedPubMedCentral Bell, M. L., Ebisu, K., Peng, R. D., Samet, J. M., & Dominici, F. (2009). Hospital admissions and chemical composition of fine particle air pollution. American Journal of Respiratory and Critical Care Medicine, 179, 1115–1120.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Block, M. L., & Calderón-Garcidueñas, L. (2009). Air pollution: Mechanisms of neuroinflammation and CNS disease. Trends in Neurosciences, 32, 506–516.CrossRefPubMedPubMedCentral Block, M. L., & Calderón-Garcidueñas, L. (2009). Air pollution: Mechanisms of neuroinflammation and CNS disease. Trends in Neurosciences, 32, 506–516.CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248–254.CrossRefPubMed Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248–254.CrossRefPubMed
8.
Zurück zum Zitat Brook, R. D., Brook, J. R., Urch, B., Vincent, R., Rajagopalan, S., & Silverman, F. (2002). Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation, 105, 1534–1536.CrossRefPubMed Brook, R. D., Brook, J. R., Urch, B., Vincent, R., Rajagopalan, S., & Silverman, F. (2002). Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation, 105, 1534–1536.CrossRefPubMed
9.
Zurück zum Zitat Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., & Mittleman, M. A. (2010). Particulate matter air pollution and cardiovascular disease. Circulation, 121, 2331–2378.CrossRefPubMed Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., & Mittleman, M. A. (2010). Particulate matter air pollution and cardiovascular disease. Circulation, 121, 2331–2378.CrossRefPubMed
10.
Zurück zum Zitat Campbell, A., Araujo, J. A., Li, H., Sioutas, C., & Kleinman, M. (2009). Particulate matter induced enhancement of inflammatory markers in the brains of apolipoprotein E knockout mice. Journal of Nanoscience and Nanotechnology, 9, 5099–5104.CrossRefPubMed Campbell, A., Araujo, J. A., Li, H., Sioutas, C., & Kleinman, M. (2009). Particulate matter induced enhancement of inflammatory markers in the brains of apolipoprotein E knockout mice. Journal of Nanoscience and Nanotechnology, 9, 5099–5104.CrossRefPubMed
11.
Zurück zum Zitat Campbell, A., Oldham, M., Becaria, A., Bondy, S. C., Meacher, D., Sioutas, C., Misra, C., Mendez, L. B., & Kleinman, M. (2005). Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. Neurotoxicology, 26, 133–140.CrossRefPubMed Campbell, A., Oldham, M., Becaria, A., Bondy, S. C., Meacher, D., Sioutas, C., Misra, C., Mendez, L. B., & Kleinman, M. (2005). Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. Neurotoxicology, 26, 133–140.CrossRefPubMed
12.
Zurück zum Zitat Campen, M. J., Nolan, J. P., Schladweiler, M. C. J., Kodavanti, U. P., Costa, D. L., & Watkinson, W. P. (2002). Cardiac and thermoregulatory effects of instilled particulate matter-associated transition metals in healthy and cardiopulmonary-compromised rats. Journal of Toxicology and Environmental Health Part A, 65, 1615–1631.CrossRefPubMed Campen, M. J., Nolan, J. P., Schladweiler, M. C. J., Kodavanti, U. P., Costa, D. L., & Watkinson, W. P. (2002). Cardiac and thermoregulatory effects of instilled particulate matter-associated transition metals in healthy and cardiopulmonary-compromised rats. Journal of Toxicology and Environmental Health Part A, 65, 1615–1631.CrossRefPubMed
13.
Zurück zum Zitat Campen, M. J., Nolan, J. P., Schladweiler, M. C. J., Kodavanti, U. P., Evansky, P. A., Costa, D. L., & Watkinson, W. P. (2001). Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: A potential interaction between nickel and vanadium sulfate. Toxicological Sciences, 64, 243–252.CrossRefPubMed Campen, M. J., Nolan, J. P., Schladweiler, M. C. J., Kodavanti, U. P., Evansky, P. A., Costa, D. L., & Watkinson, W. P. (2001). Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: A potential interaction between nickel and vanadium sulfate. Toxicological Sciences, 64, 243–252.CrossRefPubMed
14.
Zurück zum Zitat Christophersen, D. V., Jacobsen, N. R., Jensen, D. M., Kermanizadeh, A., Sheykhzade, M., Loft, S., Vogel, U., Wallin, H., & Møller, P. (2016). Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide. PLoS ONE, 11, e0160731.CrossRefPubMedPubMedCentral Christophersen, D. V., Jacobsen, N. R., Jensen, D. M., Kermanizadeh, A., Sheykhzade, M., Loft, S., Vogel, U., Wallin, H., & Møller, P. (2016). Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide. PLoS ONE, 11, e0160731.CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Costa, D. L., & Dreher, K. L. (1997). Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. Environmental Health Perspectives, 105, 1053.PubMedPubMedCentral Costa, D. L., & Dreher, K. L. (1997). Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. Environmental Health Perspectives, 105, 1053.PubMedPubMedCentral
16.
Zurück zum Zitat Cung, H., Aragon, M. J., Zychowski, K., Anderson, J. R., Nawarskas, J., Roldan, C., Sood, A., Qualls, C., & Campen, M. J. (2015). Characterization of a novel endothelial biosensor assay reveals increased cumulative serum inflammatory potential in stabilized coronary artery disease patients. Journal of Translational Medicine, 13, 99.CrossRefPubMedPubMedCentral Cung, H., Aragon, M. J., Zychowski, K., Anderson, J. R., Nawarskas, J., Roldan, C., Sood, A., Qualls, C., & Campen, M. J. (2015). Characterization of a novel endothelial biosensor assay reveals increased cumulative serum inflammatory potential in stabilized coronary artery disease patients. Journal of Translational Medicine, 13, 99.CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Dominici, F., Peng, R. D., Bell, M. L., Pham, L., McDermott, A., Zeger, S. L., & Samet, J. M. (2006). Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA, 295, 1127–1134.CrossRefPubMedPubMedCentral Dominici, F., Peng, R. D., Bell, M. L., Pham, L., McDermott, A., Zeger, S. L., & Samet, J. M. (2006). Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA, 295, 1127–1134.CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Dominici, F., Peng, R. D., Ebisu, K., Zeger, S. L., Samet, J. M., & Bell, M. L. (2007). Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environmental Health Perspectives, 115, 1701.CrossRefPubMedPubMedCentral Dominici, F., Peng, R. D., Ebisu, K., Zeger, S. L., Samet, J. M., & Bell, M. L. (2007). Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environmental Health Perspectives, 115, 1701.CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Dreher, K. L., Jaskot, R. H., Lehmann, J. R., Richards, J. H., Ghio, J. K. M. A. J., & Costa, D. L. (1997). Soluble transition metals mediate residual oil fly ash induced acute lung injury. Journal of Toxicology and Environmental Health Part A, 50, 285–305.CrossRef Dreher, K. L., Jaskot, R. H., Lehmann, J. R., Richards, J. H., Ghio, J. K. M. A. J., & Costa, D. L. (1997). Soluble transition metals mediate residual oil fly ash induced acute lung injury. Journal of Toxicology and Environmental Health Part A, 50, 285–305.CrossRef
20.
Zurück zum Zitat Dye, J. A., Lehmann, J. R., McGee, J. K., Winsett, D. W., Ledbetter, A. D., Everitt, J. I., Ghio, A. J., & Costa, D. L. (2001). Acute pulmonary toxicity of particulate matter filter extracts in rats: Coherence with epidemiologic studies in Utah Valley residents. Environmental Health Perspectives, 109, 395.PubMedPubMedCentral Dye, J. A., Lehmann, J. R., McGee, J. K., Winsett, D. W., Ledbetter, A. D., Everitt, J. I., Ghio, A. J., & Costa, D. L. (2001). Acute pulmonary toxicity of particulate matter filter extracts in rats: Coherence with epidemiologic studies in Utah Valley residents. Environmental Health Perspectives, 109, 395.PubMedPubMedCentral
21.
Zurück zum Zitat Haberzettl, P., Bhatnagar, A., & Conklin, D. J. 2014. Particulate matter and oxidative stress–pulmonary and cardiovascular targets and consequences. In Laher I (Eds.), Systems biology of free radicals and antioxidants (pp. 1557–1586). Berlin: Springer.CrossRef Haberzettl, P., Bhatnagar, A., & Conklin, D. J. 2014. Particulate matter and oxidative stress–pulmonary and cardiovascular targets and consequences. In Laher I (Eds.), Systems biology of free radicals and antioxidants (pp. 1557–1586). Berlin: Springer.CrossRef
22.
Zurück zum Zitat Harmon, M. E., Lewis, J., Miller, C., Hoover, J., Ali, A.-M. S., Shuey, C., Cajero, M., Lucas, S., Zychowski, K., & Pacheco, B. 2017. Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities. Journal of Exposure Science and Environmental Epidemiology, 27(4), 365CrossRefPubMed Harmon, M. E., Lewis, J., Miller, C., Hoover, J., Ali, A.-M. S., Shuey, C., Cajero, M., Lucas, S., Zychowski, K., & Pacheco, B. 2017. Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities. Journal of Exposure Science and Environmental Epidemiology, 27(4), 365CrossRefPubMed
23.
Zurück zum Zitat Imetkhenov, A., Dorzhiev, T., Maksarova, D., & Manketova, A. 2015. Effects of technogenic pollution of the Dzhidinsky tungsten-molybdenum plant on the health of the children of Zakamensk (Republic of Buryatia). Bulletin of Buryat State University, pp. 1–2. Imetkhenov, A., Dorzhiev, T., Maksarova, D., & Manketova, A. 2015. Effects of technogenic pollution of the Dzhidinsky tungsten-molybdenum plant on the health of the children of Zakamensk (Republic of Buryatia). Bulletin of Buryat State University, pp. 1–2.
24.
Zurück zum Zitat Kasimov, N. S., Kosheleva, N. E., & Timofeev, I. V. (2016). Ecological and geochemical assessment of woody vegetation in tungsten-molybdenum mining area (Buryat Republic, Russia). In IOP Publishing, p. 012026. Kasimov, N. S., Kosheleva, N. E., & Timofeev, I. V. (2016). Ecological and geochemical assessment of woody vegetation in tungsten-molybdenum mining area (Buryat Republic, Russia). In IOP Publishing, p. 012026.
25.
Zurück zum Zitat Keil, D., Buck, B., Goossens, D., Teng, Y., Leetham, M., Murphy, L., Pollard, J., Eggers, M., McLaurin, B., & Gerads, R. (2016). Immunotoxicological and neurotoxicological profile of health effects following subacute exposure to geogenic dust from sand dunes at the Nellis Dunes Recreation Area, Las Vegas, NV. Toxicology and Applied Pharmacology, 291, 1–12.CrossRefPubMed Keil, D., Buck, B., Goossens, D., Teng, Y., Leetham, M., Murphy, L., Pollard, J., Eggers, M., McLaurin, B., & Gerads, R. (2016). Immunotoxicological and neurotoxicological profile of health effects following subacute exposure to geogenic dust from sand dunes at the Nellis Dunes Recreation Area, Las Vegas, NV. Toxicology and Applied Pharmacology, 291, 1–12.CrossRefPubMed
26.
Zurück zum Zitat Kleinman, M. T., Araujo, J. A., Nel, A., Sioutas, C., Campbell, A., Cong, P. Q., Li, H., & Bondy, S. C. (2008). Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways. Toxicology Letters, 178, 127–130.CrossRefPubMedPubMedCentral Kleinman, M. T., Araujo, J. A., Nel, A., Sioutas, C., Campbell, A., Cong, P. Q., Li, H., & Bondy, S. C. (2008). Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways. Toxicology Letters, 178, 127–130.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Kodavanti, U. P., Hauser, R., Christiani, D. C., Meng, Z. H., McGee, J., Ledbetter, A., Richards, J., & Costa, D. L. (1998). Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicological Sciences, 43, 204–212.PubMed Kodavanti, U. P., Hauser, R., Christiani, D. C., Meng, Z. H., McGee, J., Ledbetter, A., Richards, J., & Costa, D. L. (1998). Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicological Sciences, 43, 204–212.PubMed
28.
Zurück zum Zitat Kodavanti, U. P., Schladweiler, M. C. J., Richards, J. R., & Costa, D. L. (2001). Acute lung injury from intratracheal exposure to fugitive residual oil fly ash and its constituent metals in normoand spontaneously hypertensive rats. Inhalation Toxicology, 13, 37–54.CrossRefPubMed Kodavanti, U. P., Schladweiler, M. C. J., Richards, J. R., & Costa, D. L. (2001). Acute lung injury from intratracheal exposure to fugitive residual oil fly ash and its constituent metals in normoand spontaneously hypertensive rats. Inhalation Toxicology, 13, 37–54.CrossRefPubMed
29.
Zurück zum Zitat Levesque, S., Taetzsch, T., Lull, M. E., Johnson, J. A., McGraw, C., & Block, M. L. (2013). The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function. Journal of Neurochemistry, 125, 756–765.CrossRefPubMedPubMedCentral Levesque, S., Taetzsch, T., Lull, M. E., Johnson, J. A., McGraw, C., & Block, M. L. (2013). The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function. Journal of Neurochemistry, 125, 756–765.CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Levesque, S., Taetzsch, T., Lull, M. E., Kodavanti, U., Stadler, K., Wagner, A., Johnson, J. A., Duke, L., Kodavanti, P., & Surace, M. J. (2011). Diesel exhaust activates and primes microglia: Air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. Environmental Health Perspectives, 119, 1149.CrossRefPubMedPubMedCentral Levesque, S., Taetzsch, T., Lull, M. E., Kodavanti, U., Stadler, K., Wagner, A., Johnson, J. A., Duke, L., Kodavanti, P., & Surace, M. J. (2011). Diesel exhaust activates and primes microglia: Air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. Environmental Health Perspectives, 119, 1149.CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Lippmann, M., Ito, K., Hwang, J.-S., Maciejczyk, P., & Chen, L.-C. (2006). Cardiovascular effects of nickel in ambient air. Environmental Health Perspectives, 114, 1662.CrossRefPubMedPubMedCentral Lippmann, M., Ito, K., Hwang, J.-S., Maciejczyk, P., & Chen, L.-C. (2006). Cardiovascular effects of nickel in ambient air. Environmental Health Perspectives, 114, 1662.CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Liu, Q., Babadjouni, R., Radwanski, R., Cheng, H., Patel, A., Hodis, D. M., He, S., Baumbacher, P., Russin, J. J., & Morgan, T. E. (2016). Stroke damage is exacerbated by nano-size particulate matter in a mouse model. PLoS ONE, 11, e0153376.CrossRefPubMedPubMedCentral Liu, Q., Babadjouni, R., Radwanski, R., Cheng, H., Patel, A., Hodis, D. M., He, S., Baumbacher, P., Russin, J. J., & Morgan, T. E. (2016). Stroke damage is exacerbated by nano-size particulate matter in a mouse model. PLoS ONE, 11, e0153376.CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Livak, K. J., & Schmittgen, T. D. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2 – ∆∆CT method. Methods 25, 402–408.CrossRefPubMed Livak, K. J., & Schmittgen, T. D. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2 – ∆∆CT method. Methods 25, 402–408.CrossRefPubMed
34.
Zurück zum Zitat MohanKumar, S. M. J., Campbell, A., Block, M., & Veronesi, B. (2008). Particulate matter, oxidative stress and neurotoxicity. Neurotoxicology, 29, 479–488.CrossRefPubMed MohanKumar, S. M. J., Campbell, A., Block, M., & Veronesi, B. (2008). Particulate matter, oxidative stress and neurotoxicity. Neurotoxicology, 29, 479–488.CrossRefPubMed
35.
Zurück zum Zitat Nadmitov, B., Hong, S., Kang, S. I., Chu, J. M., Gomboev, B., Janchivdorj, L., Lee, C.-H., & Khim, J. S. (2015). Large-scale monitoring and assessment of metal contamination in surface water of the Selenga River Basin (2007–2009). Environmental Science and Pollution Research, 22, 2856–2867.CrossRefPubMed Nadmitov, B., Hong, S., Kang, S. I., Chu, J. M., Gomboev, B., Janchivdorj, L., Lee, C.-H., & Khim, J. S. (2015). Large-scale monitoring and assessment of metal contamination in surface water of the Selenga River Basin (2007–2009). Environmental Science and Pollution Research, 22, 2856–2867.CrossRefPubMed
36.
Zurück zum Zitat Niu, J., Liberda, E. N., Qu, S., Guo, X., Li, X., Zhang, J., Meng, J., Yan, B., Li, N., & Zhong, M. (2013). The role of metal components in the cardiovascular effects of PM2. 5. PLoS ONE, 8, e83782.CrossRefPubMedPubMedCentral Niu, J., Liberda, E. N., Qu, S., Guo, X., Li, X., Zhang, J., Meng, J., Yan, B., Li, N., & Zhong, M. (2013). The role of metal components in the cardiovascular effects of PM2. 5. PLoS ONE, 8, e83782.CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Paffett, M. L., Zychowski, K. E., Sheppard, L., Robertson, S., Weaver, J. M., Lucas, S. N., & Campen, M. J. 2015. Ozone inhalation impairs coronary artery dilation via intracellular oxidative stress: Evidence for serum-borne factors as drivers of systemic toxicity. Toxicological Sciences, 146(2), 244–253.CrossRef Paffett, M. L., Zychowski, K. E., Sheppard, L., Robertson, S., Weaver, J. M., Lucas, S. N., & Campen, M. J. 2015. Ozone inhalation impairs coronary artery dilation via intracellular oxidative stress: Evidence for serum-borne factors as drivers of systemic toxicity. Toxicological Sciences, 146(2), 244–253.CrossRef
38.
Zurück zum Zitat Peters, A., Veronesi, B., Calderón-Garcidueñas, L., Gehr, P., Chen, L. C., Geiser, M., Reed, W., Rothen-Rutishauser, B., Schürch, S., & Schulz, H. (2006). Translocation and potential neurological effects of fine and ultrafine particles a critical update. Particle and Fibre Toxicology, 3, 13.CrossRefPubMedPubMedCentral Peters, A., Veronesi, B., Calderón-Garcidueñas, L., Gehr, P., Chen, L. C., Geiser, M., Reed, W., Rothen-Rutishauser, B., Schürch, S., & Schulz, H. (2006). Translocation and potential neurological effects of fine and ultrafine particles a critical update. Particle and Fibre Toxicology, 3, 13.CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat Sapkota, A., Chelikowsky, A. P., Nachman, K. E., Cohen, A. J., & Ritz, B. (2012). Exposure to particulate matter and adverse birth outcomes: A comprehensive review and meta-analysis. Air Quality, Atmosphere and Health, 5, 369–381.CrossRef Sapkota, A., Chelikowsky, A. P., Nachman, K. E., Cohen, A. J., & Ritz, B. (2012). Exposure to particulate matter and adverse birth outcomes: A comprehensive review and meta-analysis. Air Quality, Atmosphere and Health, 5, 369–381.CrossRef
40.
Zurück zum Zitat Silverman, J., Suckow, M. A., & Murthy, S. 2014. The IACUC handbook. Boca Raton: CRC Press. Silverman, J., Suckow, M. A., & Murthy, S. 2014. The IACUC handbook. Boca Raton: CRC Press.
41.
Zurück zum Zitat Smirnova, O. K., Doroshkevich, C. G., & Dampilova, B. V. 2013. Assessment of trends of changes in the content of toxic elements in the soils of the city of Zakamensk after the conservation of the Dzhidnsky tungsten-molybdenum plant. Geodynamics and mineralogy of Northeast Asia. Materials of the IV All-Russian Scientific and Practical Conference. Ulan-Ude: Publishing house “Ecos”, pp. 327–330. Smirnova, O. K., Doroshkevich, C. G., & Dampilova, B. V. 2013. Assessment of trends of changes in the content of toxic elements in the soils of the city of Zakamensk after the conservation of the Dzhidnsky tungsten-molybdenum plant. Geodynamics and mineralogy of Northeast Asia. Materials of the IV All-Russian Scientific and Practical Conference. Ulan-Ude: Publishing house “Ecos”, pp. 327–330.
42.
Zurück zum Zitat Timofeev, I. V., Kasimov, N. S., & Kosheleva, N. E. (2016). Soil cover geochemistry of mining landscapes in the South-East of Transbaikalia (City of Zakamensk). Geography and Natural Resources, 37, 200–211.CrossRef Timofeev, I. V., Kasimov, N. S., & Kosheleva, N. E. (2016). Soil cover geochemistry of mining landscapes in the South-East of Transbaikalia (City of Zakamensk). Geography and Natural Resources, 37, 200–211.CrossRef
43.
Zurück zum Zitat Ubugunov, V., Dorzhonova, V., & Ubugunov, L. (2014). Cd extraction potential of Thlaspi caerulescens in extracontinental climate conditions (Zakamensk, Buryatia, Russia). Journal of Geochemical Exploration, 144, 380–386.CrossRef Ubugunov, V., Dorzhonova, V., & Ubugunov, L. (2014). Cd extraction potential of Thlaspi caerulescens in extracontinental climate conditions (Zakamensk, Buryatia, Russia). Journal of Geochemical Exploration, 144, 380–386.CrossRef
44.
Zurück zum Zitat Woodward, N. C., Levine, M. C., Haghani, A., Shirmohammadi, F., Saffari, A., Sioutas, C., Morgan, T. E., & Finch, C. E. (2017). Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo. Journal of neuroinflammation, 14, 84.CrossRefPubMedPubMedCentral Woodward, N. C., Levine, M. C., Haghani, A., Shirmohammadi, F., Saffari, A., Sioutas, C., Morgan, T. E., & Finch, C. E. (2017). Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo. Journal of neuroinflammation, 14, 84.CrossRefPubMedPubMedCentral
45.
Zurück zum Zitat Wu, S., Deng, F., Hao, Y., Shima, M., Wang, X., Zheng, C., Wei, H., Lv, H., Lu, X., & Huang, J. (2013). Chemical constituents of fine particulate air pollution and pulmonary function in healthy adults: The Healthy Volunteer Natural Relocation study. Journal of hazardous materials, 260, 183–191.CrossRefPubMed Wu, S., Deng, F., Hao, Y., Shima, M., Wang, X., Zheng, C., Wei, H., Lv, H., Lu, X., & Huang, J. (2013). Chemical constituents of fine particulate air pollution and pulmonary function in healthy adults: The Healthy Volunteer Natural Relocation study. Journal of hazardous materials, 260, 183–191.CrossRefPubMed
46.
Zurück zum Zitat Yoo, G. Y., & Kim, I. A. 2008. Development and application of a climate change vulnerability index (pp. 1–88). Sejong: Korea Environment Institute. Yoo, G. Y., & Kim, I. A. 2008. Development and application of a climate change vulnerability index (pp. 1–88). Sejong: Korea Environment Institute.
47.
Zurück zum Zitat Zychowski, K. E., Sanchez, B., Pedrosa, R. P., Lorenzi-Filho, G., Drager, L. F., Polotsky, V. Y., & Campen, M. J. (2016). Serum from obstructive sleep apnea patients induces inflammatory responses in coronary artery endothelial cells. Atherosclerosis, 254, 59–66.CrossRefPubMedPubMedCentral Zychowski, K. E., Sanchez, B., Pedrosa, R. P., Lorenzi-Filho, G., Drager, L. F., Polotsky, V. Y., & Campen, M. J. (2016). Serum from obstructive sleep apnea patients induces inflammatory responses in coronary artery endothelial cells. Atherosclerosis, 254, 59–66.CrossRefPubMedPubMedCentral
Metadaten
Titel
Toxic Effects of Particulate Matter Derived from Dust Samples Near the Dzhidinski Ore Processing Mill, Eastern Siberia, Russia
verfasst von
Katherine E. Zychowski
Abigail Wheeler
Bethany Sanchez
Molly Harmon
Christina R. Steadman Tyler
Guy Herbert
Selita N. Lucas
Abdul-Mehdi Ali
Sumant Avasarala
Nitesh Kunda
Paul Robinson
Pavan Muttil
Jose M. Cerrato
Barry Bleske
Olga Smirnova
Matthew J. Campen
Publikationsdatum
08.04.2019
Verlag
Springer US
Erschienen in
Cardiovascular Toxicology / Ausgabe 5/2019
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-019-09507-y

Weitere Artikel der Ausgabe 5/2019

Cardiovascular Toxicology 5/2019 Zur Ausgabe