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Association of Single Nucleotide Polymorphisms in Tumor Necrosis Factor-Alpha with Cervical Cancer Susceptibility

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Abstract

Tumor necrosis factor-alpha (TNF-α) polymorphisms have been reported to play an important role in the development of cervical cancer. But the results remain inconclusive. We performed this study to provide a comprehensive assessment of the association by means of a meta-analysis in which all published studies were included. The studies investigating the associations between cervical cancer risk and TNF-α polymorphisms were identified through PubMed, Embase, CNKI, and Chinese BioMedical Literature Database. OR and 95 % CI (odds ratio and 95 % confidence interval) were calculated using either the fixed or random effects model to assess the associations. We eventually included eighteen case–control studies of SNP −308 G>A and nine studies of SNP −238 G>A. Meta-analysis of the former polymorphism suggested significantly increased risk of cervical cancer associated with the A allele (OR 1.19, 95 % CI 1.02–1.38). Subgroup analysis according to ethnicity showed similar results in Caucasians (A vs. G: OR 1.25, 95 % CI 1.02–1.54; AA vs. GG: OR 1.47, 95 % CI 1.04–2.08; AA vs. GA+GG: OR 1.47, 95 % CI 1.04–2.08). For SNP −238 G>A, a protective association was observed in overall comparisons (A vs. G: OR 0.64, 95 % CI 0.51–0.80; AA+GA vs. GG: OR 0.62, 95 % CI 0.49–0.79) and subgroup analysis of Caucasians (A vs. G: OR 0.67, 95 % CI 0.53–0.83; AA+GA vs. GG: OR 0.65, 95 % CI 0.51–0.82). Our meta-analysis indicates that TNF-α polymorphisms may confer susceptibility to cervical cancer in an ethic-specific fashion.

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Acknowledgments

Acknowledgement is made to National Natural Science Foundation of China (30970761).

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  1. Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Ying Jin

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Jin, Y. Association of Single Nucleotide Polymorphisms in Tumor Necrosis Factor-Alpha with Cervical Cancer Susceptibility. Cell Biochem Biophys 71, 77–84 (2015). https://doi.org/10.1007/s12013-014-0165-4

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  • DOI: https://doi.org/10.1007/s12013-014-0165-4

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