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The Ins and Outs of Hematopoietic Stem Cells: Studies to Improve Transplantation Outcomes

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Abstract

Deciphering the mechanisms of hematopoietic stem/progenitor cell (HSPC) mobilization and homing is important for the development of strategies to enhance the efficacy of HSPC transplantation and achieve the full potential of HSPC-based cellular therapy. Investigation of these mechanisms has revealed interdependence among the various molecules, pathways and cellular components involved, and underscored the complex nature of these two processes. This review summarizes recent progress in identifying the specific factors implicated in HSPC mobilization and homing, with emphasis on our own work. Particularly, we will discuss our studies on stromal cell-derived factor-1 and its interaction with its receptor CXCR4, proteases (matrix metalloproteinases and carboxypeptidase M), complement proteins (C1q, C3a, C5a, membrane attack complex), sphingosine-1-phosphate, and pharmacologic agents such as the histone deacetylase inhibitor valproic acid and hyaluronic acid.

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Acknowledgments

Our research on “Mechanisms of HSPC Mobilization and Homing” has been funded by an operating grant (XE00025) from the Canadian Blood Services (CBS) Research and Development/Canadian Institutes for Health Research Blood Utilization and Conservation Partnership Initiative to AJW and a National Institutes of Health grant (ROI CA105847) to MZR. We thank the staff of the Stem Cell Transplant Program and the CBS Stem Cell Processing Laboratory in Edmonton for procurement of patient samples.

The authors declare no potential conflicts of interest.

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Authors and Affiliations

  1. Research & Development, Canadian Blood Services, CBS Edmonton Centre, 8249-114 St. NW, Edmonton, T6G 2R8, Alberta, Canada

    Leah A. Marquez-Curtis, Santhi Sridharan & Anna Janowska-Wieczorek

  2. Departments of Medicine and Oncology, University of Alberta, Edmonton, Alberta, Canada

    A. Robert Turner & Anna Janowska-Wieczorek

  3. Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

    Mariusz Z. Ratajczak

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  1. Leah A. Marquez-Curtis
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  5. Anna Janowska-Wieczorek
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Correspondence to Anna Janowska-Wieczorek.

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Marquez-Curtis, L.A., Turner, A.R., Sridharan, S. et al. The Ins and Outs of Hematopoietic Stem Cells: Studies to Improve Transplantation Outcomes. Stem Cell Rev and Rep 7, 590–607 (2011). https://doi.org/10.1007/s12015-010-9212-8

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  • DOI: https://doi.org/10.1007/s12015-010-9212-8

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