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Clinical Reviews in Allergy & Immunology

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01.06.2012

A Novel Algorithm for the Diagnosis of Celiac Disease and a Comprehensive Review of Celiac Disease Diagnostics

verfasst von: Orit Rozenberg, Aaron Lerner, Avi Pacht, Maya Grinberg, Dina Reginashvili, Clara Henig, Mira Barak

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 3/2012

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Abstract

There is an urgent clinical need for a better laboratory celiac disease diagnosis with both less false positive results and minimal underdetection. The aim of the present study was to evaluate the performance and diagnostic accuracy of different assays in an outpatient population setting for the diagnosis for celiac disease (CD) in order to design an optimal algorithm. We used 15 different ELISA assays to assess 47 blood samples of newly diagnosed children (positive biopsy results) and 52 samples from age- and sex-matched children with negative biopsy results for CD. Scoring criteria were established for grading the assays performance and characteristics. The combined gliadin and tTG assays exhibited the best sensitivity (100%). The addition of other assays to the CeliCheck neo-epitopes assay improved specificity so that the final algorithm had 100% sensitivity, 96.2% specificity, and 98.1% accuracy. The clinical demand for both maximal sensitivity and maximal specificity cannot be achieved with a single test. Using a combination of a sensitive assay together with specific assays improved celiac disease detection rates, with an acceptable number of false positive results. This model, however, needs to be confirmed prospectively in both children and adults.

Gasbarrini G, Malandrino N, Giorgio V, Fundarò C, Cammarota G, Merra G et al (2008) Celiac disease: what's new about it? Dig Dis 26:121–127PubMedCrossRef

Green PH, Cellier C (2007) Celiac disease. N Engl J Med 357:1731–1743PubMedCrossRef

Schuppan D, Hahn EG (2001) IgA anti-tissue transglutaminase: setting the stage for coeliac disease screening. Eur J Gastroenterol Hepatol 13:635–637PubMedCrossRef

Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO et al (1997) Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3:797–801PubMedCrossRef

Van de Wal Y, Kooy Y, van Veelen P, Pena S, Mearin L, Papadopoulos G et al (1998) Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T-cell reactivity. J Immunol 161:1585–1588PubMed

Armstrong MJ, Robins GG, Howdle PD (2009) Recent advances in coeliac disease. Curr Opin Gastroenterol 25:100–109PubMedCrossRef

Mustalahti K, Catassi C, Reunanen A, Fabiani E, Heier M, McMillan S et al (2010) The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med 42:587–595PubMedCrossRef

Lerner A (2010) An additional piece in the Israeli celiac disease puzzle. Isr Med Assoc J 12:305–306PubMed

Shamir R, Lerner A, Shinar E, Lahat N, Sobel E, Bar-or R et al (2002) The use of a single serological marker underestimates the prevalence of celiac disease in Israel: a study of blood donors. Am J Gastroenterol 97:2589–2594PubMedCrossRef

10.

Catassi C, Ratsch IM, Fabiani E, Rossini M, Bordicchia F, Candela F et al (1994) Coeliac disease in the year 2000: exploring the iceberg. Lancet 343:200–203PubMedCrossRef

11.

Hadjivassiliou M, Sanders DS, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D (2010) Gluten sensitivity: from gut to brain. Lancet Neurol 9:318–330PubMedCrossRef

12.

Roma E, Panayiotou J, Karantana H, Constantinidou C, Siakavellas SI, Krini M et al (2009) Changing pattern in the clinical presentation of pediatric celiac disease: a 30-year study. Digestion 80:185–191PubMedCrossRef

13.

Barker JM, Liu E (2008) Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditions. Adv Pediatr 55:349–365PubMedCrossRef

14.

Buzby M (2010) Celiac disease: the endocrine connection. J Pediatr Nurs 25:311–313PubMedCrossRef

15.

Godfrey JD, Brantner TL, Brinjikji W, Christensen KN, Brogan DL, Van Dyke CT et al (2010) Morbidity and mortality among older individuals with undiagnosed celiac disease. Gastroenterology 139:763–769PubMedCrossRef

16.

Fernández A, González L, de-la-Fuente J (2010) Coeliac disease: clinical features in adult populations. Rev Esp Enferm Dig 102:466–471PubMed

17.

Korkut E, Bektas M, Oztas E, Kurt M, Cetinkaya H, Ozden A (2010) The prevalence of celiac disease in patients fulfilling Rome III criteria for irritable bowel syndrome. Eur J Intern Med 21:389–392PubMedCrossRef

18.

Zugna D, Richiardi L, Akre O, Stephansson O, Ludvigsson JF (2010) A nationwide population-based study to determine whether coeliac disease is associated with infertility. Gut 59:1471–1475PubMedCrossRef

19.

Gabrielli M, Candelli M, Franceschi F, Cremonini F, Nista EC, Santarelli L et al (2004) Primary autoimmune haemolytic anaemia and coeliac disease. Scand J Gastroenterol 39:605–606PubMedCrossRef

20.

Freeman HJ (2008) Neurological disorders in adult celiac disease. Can J Gastroenterol 22:909–911PubMed

21.

Nachman F, Vázquez H, González A, Andrenacci P, Compagni L, Reyes H et al (2010) Gastroesophageal reflux symptoms in patients with celiac disease and the effects of a gluten-free diet. Clin Gastroenterol Hepatol (in press)

22.

Fasano A, Araya M, Bhatnagar S, Cameron D, Catassi C, Dirks M et al (2008) Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition consensus report on celiac disease. J Pediatr Gastroenterol Nutr 47:214–219PubMedCrossRef

23.

Koskinen O, Collin P, Lindfors K, Laurila K, Mäki M, Kaukinen K (2010) Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease. J Clin Gastroenterol 44:483–488PubMed

24.

Freeman HJ (2004) Adult celiac disease and the severe “flat” small bowel biopsy lesion. Dig Dis Sci 49:535–545PubMedCrossRef

25.

Vogelsang H, Häne lS, Steiner B, Oberhuber G (2001) Diagnostic duodenal bulb biopsy in celiac disease. Endoscopy 33:336–340PubMedCrossRef

26.

Bonamico M, Mariani P, Thanasi E, Ferri M, Nenna R, Tiberi C et al (2004) Patchy villous atrophy of duodenum in childhood celiac disease. J Pediatr Gastroenterol Nutr 38:204–207PubMedCrossRef

27.

Marsh MN (1992) Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (“celiac sprue”). Gastroenterology 102:330–354PubMed

28.

Collin P, Kaukinen K, Vogelsang H, Korponay-Szabó I, Sommer R, Schreier E et al (2005) Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of celiac disease: a biopsy proven European multicentre study. Eur J Gastroenterol Hepatol 17:85–91PubMedCrossRef

29.

Collin P (1999) New diagnostic findings in celiac disease. Ann Med 31:399–405PubMedCrossRef

30.

Meuwisse GW (1970) Diagnostic criteria in coeliac disease. Acta Paediatr Scand 59:461CrossRef

31.

Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 65:909–911

32.

Bürgin-Wolff A, Hernandez R, Just M, Signer E (1976) Immunofluorescent antibodies against gliadin: a screening test for coeliac disease. Helv Paediatr Acta 31:375–380PubMed

33.

Savilahti E, Viander M, Perkkiö M, Vainio E, Kalimo K, Reunala T (1983) IgA antigliadin antibodies: a marker of mucosal damage in childhood coeliac disease. Lancet 1:320–322PubMedCrossRef

34.

Kumar V, Jain N, Lerner A, Beutner EH, Chorzelski TP, Lebenthal E (1986) Comparative studies of different gliadin preparations in detecting antigliadin antibodies. J Pediatr Gastroenterol Nutr 5:730–734PubMedCrossRef

35.

Hill ID (2005) What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Gastroenterology 128:S25–S32PubMedCrossRef

36.

Burgin-Wolff A, Gaze H, Hadziselimovic F, Huber H, Lentze MJ, Nussle D et al (1991) Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child 66:941–947PubMedCrossRef

37.

Chorzelski TP, Beutner EH, Sulej J, Tchorzewska H, Jablonska S, Kumar V et al (1984) IgA anti-endomysium antibody. A new immunological marker of dermatitis herpetiformis and coeliac disease. Br J Dermatol 111:395–402PubMedCrossRef

38.

Dieterich W, Laag E, Schöpper H, Volta U, Ferguson A, Gillett H et al (1998) Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 115:1317–1321PubMedCrossRef

39.

Biagi F, Klersy C, Balduzzi D, Corazza GR (2010) Are we not over-estimating the prevalence of coeliac disease in the general population? Ann Med 42:557–561PubMedCrossRef

40.

Aleanzi M, Demonte AM, Esper C, Garcilazo S, Waggener M (2001) Celiac disease: antibody recognition against native and selectively deamidated gliadin peptides. Clin Chem 47:2023–2028PubMed

41.

Skovbjerg H, Koch C, Anthonsen D, Sjöström H (2004) Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease. Biochim Biophys Acta 1690:220–230PubMed

42.

Matthias T, Pfeiffer S, Selmi C, Gershwin ME (2010) Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope. Clin Rev Allergy Immunol 38:298–301PubMedCrossRef

43.

Reeves GE, Squance ML, Duggan AE, Murugasu RR, Wilson RJ, Wong RC et al (2006) Diagnostic accuracy of coeliac serological tests: a prospective study. Eur J Gastroenterol Hepatol 18:493–501PubMedCrossRef

44.

Fasano A, Not T, Wang W, Uzzau S, Berti I, Tommasini A et al (2000) Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 355:1518–1519PubMedCrossRef

45.

Duerksen DR, Wilhelm-Boyles C, Veitch R, Kryszak D, Parry DM (2010) A comparison of antibody testing, permeability testing, and zonulin levels with small-bowel biopsy in celiac disease patients on a gluten-free diet. Dig Dis Sci 55:1026–1031PubMedCrossRef

46.

Vivas S, Ruiz de Morales JG, Riestra S, Arias L, Fuentes D, Alvarez N et al (2009) Duodenal biopsy may be avoided when high transglutaminase antibody titers are present. World J Gastroenterol 15:4775–4780PubMedCrossRef

47.

Sugai E, Nachman F, Váquez H, González A, Andrenacci P, Czech A et al (2010) Dynamics of celiac disease-specific serology after initiation of a gluten-free diet and use in the assessment of compliance with treatment. Dig Liver Dis 42:352–358PubMedCrossRef

48.

Carroccio A, Brusca I, Iacono G, Di Prima L, Teresa S, Pirrone G et al (2005) Anti-actin antibodies in celiac disease: correlation with intestinal mucosal damage and comparison of ELISA with immunofluorescence assay. Clin Chem 51:917–920PubMedCrossRef

49.

Basso D, Guariso G, Fogar P, Meneghel A, Zambon CF, Navaglia F et al (2009) Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children. Clin Chem 55:150–157PubMedCrossRef

50.

James SP (2005) This month at the NIH: final statement of NIH Consensus Conference on celiac disease. Gastroenterology 128:6PubMedCrossRef

51.

Kumar V, Jarzabek-Chorzelska M, Sulej J, Karnewska K, Farrell T, Jablonska S (2002) Celiac disease and immunoglobulin A deficiency: how effective are the serological methods of diagnosis? Clin Diagn Lab Immunol 9:1295–1300PubMed

52.

Shamir R, Eliakim R, Lahat N, Sobe lE, Lerner A (2002) ELISA of anti-endomysial antibodies in the diagnosis of celiac disease: comparison with immunofluorescence assay of anti-endomysial antibodies and tissue transglutaminase antibodies. Isr Med Assoc J 4:594–596PubMed

53.

Broide E, Sandbank J, Scapa E, Kimchi NA, Shapiro M, Lerner A (2007) The immunohistochemistry profile of lymphocytic gastritis in celiac disease and Helicobacter pylori infection: interplay between infection and inflammation. Mediat Inflamm 2007:81838CrossRef

54.

Sugai E, Hwang HJ, Vázquez H, Smecuol E, Niveloni S, Mazure R et al (2010) New serology assays can detect gluten sensitivity among enteropathy patients seronegative for anti-tissue transglutaminase. Clin Chem 56:661–665PubMedCrossRef

55.

Jaskowski TD, Donaldson MR, Hull CM, Wilson AR, Hill HR, Zone JJ, Book LS (2010) Novel screening assay performance in pediatric celiac disease and adult dermatitis herpetiformis. J Pediatr Gastroenterol Nutr 51:19–23PubMedCrossRef

56.

Aberg AK, Olcén P (2009) Serologic screening for celiac disease in children: a comparison between established assays and tests with deamidated gliadin-derived peptides plus conjugates for both IgA and IgG antibodies. APMIS 117:808–813PubMedCrossRef

57.

Basso D, Guariso G, Fasolo M, Pittoni M, Schiavon S, Fogar P et al (2006) A new indirect chemiluminescent immunoassay to measure anti-tissue transglutaminase antibodies. J Pediatr Gastroenterol Nutr 43:613–618PubMedCrossRef

58.

Rostom A, Dubé C, Cranney A, Saloojee N, Sy R, Garritty C et al (2005) The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology 128:S38–S46PubMedCrossRef

59.

van der Windt DA, Jellema P, Mulder CJ, Kneepkens CM, van der Horst HE (2010) Diagnostic testing for celiac disease among patients with abdominal symptoms: a systematic review. JAMA 303:1738–1746PubMedCrossRef

60.

Leffler DA, Schuppan D (2010) Update on serologic testing in celiac disease. Am J Gastroenterol 105:2520–2524PubMedCrossRef

61.

Kurppa K, Lindfors K, Collin P, Saavalainen P, Partanen J, Haimila K et al (2010) Antibodies against deamidated gliadin peptides in early-stage celiac disease. J Clin Gastroenterol (in press)

62.

Tonutti E, Visentini D, Picierno A, Bizzaro N, Villalta D, Tozzoli R et al (2009) Diagnostic efficacy of the ELISA test for the detection of deamidated anti-gliadin peptide antibodies in the diagnosis and monitoring of celiac disease. J Clin Lab Anal 23:165–171PubMedCrossRef

63.

Volta U, Granito A, Parisi C, Fabbri A, Fiorini E, Piscaglia M et al (2010) Deamidated gliadin peptide antibodies as a routine test for celiac disease: a prospective analysis. J Clin Gastroenterol 44:186–190PubMedCrossRef

64.

Bansal AK, Lindemann MJ, Ramsperger V, Kumar V (2009) Celiac G+ antibody assay for the detection of autoantibodies in celiac disease. Ann NY Acad Sci 1173:36–40PubMedCrossRef

65.

Weir DC, Glickman JN, Roiff T, Valim C, Leichtner AM (2010) Variability of histopathological changes in childhood celiac disease. Am J Gastroenterol 105:207–212PubMedCrossRef

66.

Rashid M, MacDonald A (2009) Importance of duodenal bulb biopsies in children for diagnosis of celiac disease in clinical practice. BMC Gastroenterol 9:78PubMedCrossRef

67.

Walker MM, Murray JA, Ronkainen J, Aro P, Storskrubb T, D'Amato M et al (2010) Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology 139:112–119PubMedCrossRef

68.

Elli l, Bonura A, Bardella MT (2009) Avoiding duodenal endoscopies in celiac disease: are we going forward or looking to the past. Dig Liver Dis 42:154–155PubMedCrossRef

69.

Sugai E, Moreno ML, Hwang HJ, Cabanne A, Crivelli A, Nachman F et al (2010) Celiac disease serology in patients with different pretest probabilities: is biopsy avoidable? World J Gastroenterol 16:3144–3152PubMedCrossRef

70.

Plenge RM (2008) Shared genetic risk factors for type 1 diabetes and celiac disease. N Engl J Med 359:2837–2838PubMedCrossRef

71.

Shaoul R, Lerner A (2007) Associated autoantibodies in celiac disease. Autoimmun Rev 6:559–565PubMedCrossRef

72.

Simell S, Hoppu S, Simell T, Ståhlberg MR, Viander M, Routi T et al (2010) Age at development of type 1 diabetes- and celiac disease-associated antibodies and clinical disease in genetically susceptible children observed from birth. Diab Care 33:774–779CrossRef

73.

Lerner A (2010) New therapeutic strategies for celiac disease. Autoimmun Rev 9:144–147PubMedCrossRef

Titel: A Novel Algorithm for the Diagnosis of Celiac Disease and a Comprehensive Review of Celiac Disease Diagnostics
verfasst von: Orit Rozenberg
Aaron Lerner
Avi Pacht
Maya Grinberg
Dina Reginashvili
Clara Henig
Mira Barak
Publikationsdatum: 01.06.2012
Verlag: Humana Press Inc
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 3/2012
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-010-8250-y

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A Novel Algorithm for the Diagnosis of Celiac Disease and a Comprehensive Review of Celiac Disease Diagnostics

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