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Clinical Reviews in Allergy & Immunology

Erschienen in:

01.10.2013

Immunoglobulin-Mediated Neuro-Cognitive Impairment: New Data and a Comprehensive Review

verfasst von: Assaf Menachem, Joab Chapman, Yael Deri, Chaim G. Pick, Aviva Katzav

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2/2013

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Abstract

Excessive influx of immunoglobulin (IgG) into the brain has been reported to induce central nervous system (CNS) dysfunction. Depressed patients may exhibit immune activation manifested by elevated inflammatory markers and pro-inflammatory cytokines. The brain and especially the limbic system contain high concentrations of high affinity Fc receptors. We reviewed the literature on this phenomena and present data on the behavioral effects of pooled normal IgG on the brain. Many disease states are associated with depression and we examined whether this may be linked to high IgG influx. Female Balb/C mice were injected intra-cerbroventricularly with human immunoglobulin whole molecule, or human IgG F(ab′)₂ or Fc fragments. Control mice were injected with saline. The four groups were subjected to behavioral (staircase, forced swimming test, and elevated plus maze) and cognitive tests (passive avoidance test). IgG-injected mice exhibited depression-like behavior as reflected by significantly higher immobility time in the forced swimming test (p < 0.05) and hyperactive behavior as reflected by higher number of stairs climbed in the staircase test compared to controls (p < 0.01). Fc-fragments-injected mice showed hyperactive behavior as reflected by both higher number of stairs climbed and rearing events in the staircase test compared to controls. The results indicate that high levels of normal IgG in the cerebrospinal fluid can cause hyperactivity and depression-like behavior. The mechanism involved in these CNS manifestations include possibly Fc receptor binding.

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Titel: Immunoglobulin-Mediated Neuro-Cognitive Impairment: New Data and a Comprehensive Review
verfasst von: Assaf Menachem
Joab Chapman
Yael Deri
Chaim G. Pick
Aviva Katzav
Publikationsdatum: 01.10.2013
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 2/2013
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-013-8357-z

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Immunoglobulin-Mediated Neuro-Cognitive Impairment: New Data and a Comprehensive Review

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Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

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