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Clinical Reviews in Allergy & Immunology

Erschienen in:

01.02.2016

Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response

verfasst von: Ervin Ç. Mingomataj, Alketa H. Bakiri

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 1/2016

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Abstract

The interleukin-10 (IL-10) is generally considered as the most important cytokine with anti-inflammatory properties and one of the key cytokines preventing inflammation-mediated tissue damage. In this respect, IL-10 producing cells play a crucial role in the outcome of infections, allergy, autoimmune reactions, tumor development, and transplant tolerance. Based on recent findings with regard to the mentioned clinical conditions, this review attempts to shed some light on the IL-10 functions, considering this cytokine as inherent inducer of the switching immunity. While acute infections and vaccinations are associated by IL-10 enhanced during few weeks, chronic parasitoses, tumor diseases, allergen-specific immunotherapy, transplants, and use of immune-suppressor drugs show an increased IL-10 level along months or years. With regard to autoimmune pathologies, the IL-10 increase is prevalently observed during early stages, whereas the successive stages are characterized by reaching of immune equilibrium independently to disease’s activity. Together, these findings indicate that IL-10 is mainly produced during transient immune conditions and the persistent IL-10-related effect is the indication/prediction (and maybe effectuation) of the switching immunity. Actual knowledge emphasizes that any manipulation of the IL-10 response for treatment purposes should be considered very cautiously due to its potential hazards to the immune system. Probably, the IL-10 as potential switcher of immunity response should be used in association with co-stimulatory immune effectors that are necessary to determine the appropriate deviation during treatment of respective pathologies. Hopefully, further findings would open new avenues to study the biology of this “master switch” cytokine and its therapeutic potential.

Cools N, Ponsaerts P, Van Tendeloo VF, Berneman ZN (2007) Regulatory T cells and human disease. Clin Dev Immunol 2007:89195PubMedCentralPubMedCrossRef

Bouabe H (2012) Cytokine reporter mice: the special case of IL-10. Scand J Immunol 75:553–567PubMedCrossRef

Dasgupta A, Saxena R (2012) Regulatory T cells: a review. Natl Med J India 25:341–351PubMed

Sabat R, Grütz G, Warszawska K et al (2010) Biology of interleukin-10. Cytokine Growth Factor Rev 21:331–344PubMedCrossRef

Mosser DM, Zhang X (2008) Interleukin-10: new perspectives on an old cytokine. Immunol Rev 226:205–218PubMedCentralPubMedCrossRef

Lim SH, Park E, You B et al (2013) Neuronal synapse formation induced by microglia and interleukin-10. PLoS One 8:e81218

Shen KF, Zhu HQ, Wei XH et al (2013) Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Exp Neurol 247:466–475PubMedCrossRef

Carlsson E, Frostell A, Ludvigsson J, Faresjö M (2014) Psychological stress in children may alter the immune response. J Immunol 192:2071–2081PubMedCrossRef

Wadley AJ, Chen YW, Lip GY, Fisher JP, Aldred S (2015) Low volume-high intensity interval exercise elicits antioxidant and anti-inflammatory effects in humans. J Sports Sci 1–9. doi:10.1080/02640414.2015.1035666

10.

Daniele S, Da Pozzo E, Zappelli E, Martini C (2015) Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK. Cell Signal 27:1609–1629PubMedCrossRef

11.

Zhao Q, Xie X, Fan Y et al (2015) Phenotypic dysregulation of microglial activation in young offspring rats with maternal sleep deprivation-induced cognitive impairment. Sci Rep 5:9513PubMedCrossRef

12.

Gill SK, Teixeira A, Rama L et al (2015) Circulatory endotoxin concentration and cytokine profile in response to exertional-heat stress during a multi-stage ultra-marathon competition. Exerc Immunol Rev 21:114–128PubMed

13.

Wang J, Yu J, Ding CP, Han SP, Zeng XY, Wang JY (2015) Transforming growth factor-beta in the red nucleus plays antinociceptive effect under physiological and pathological pain conditions. Neuroscience 291:37–45PubMedCrossRef

14.

Haas B, Chrusciel S, Fayad-Kobeissi S et al (2015) Permanent culture of macrophages at physiological oxygen attenuates the antioxidant and immunomodulatory properties of dimethyl fumarate. J Cell Physiol 230:1128–1138PubMedCrossRef

15.

Kalinichenko LS, Pertsov SS, Koplik EV (2014) Melatonin effects on serum cytokine profiles of rats with different behavioral parameters in acute emotional stress. Bull Exp Biol Med 156:627–630PubMedCrossRef

16.

Rowsell GJ, Reaburn P, Toone R, Smith M, Coutts AJ (2014) Effect of run training and cold-water immersion on subsequent cycle training quality in high-performance triathletes. J Strength Cond Res 28:1664–1672PubMedCrossRef

17.

Janes K, Esposito E, Doyle T et al (2014) A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways. Pain 155:2560–2567PubMedCentralPubMedCrossRef

18.

Cerejeira J, Batista P, Nogueira V, Vaz-Serra A, Mukaetova-Ladinska EB (2013) The stress response to surgery and postoperative delirium: evidence of hypothalamic-pituitary-adrenal axis hyperresponsiveness and decreased suppression of the GH/IGF-1 axis. J Geriatr Psychiatry Neurol 26:185–194PubMedCrossRef

19.

Matzner P, Hazut O, Naim R et al (2013) Resilience of the immune system in healthy young students to 30-hour sleep deprivation with psychological stress. Neuroimmunomodulation 20:194–204PubMedCrossRef

20.

Voorhees JL, Tarr AJ, Wohleb ES et al (2013) Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10. PLoS One 8:e58488

21.

Koh KB, Lee YJ, Beyn KM, Chu SH, Kim DM, Seo WY (2012) Effects of high and low stress on proinflammatory and antiinflammatory cytokines. Psychophysiology 49:1290–1297PubMedCrossRef

22.

Hwang WS, Kim HI, Kim YJ et al (2013) Pregnancy in postpartum estrus induces inflammatory milk production and catagen specific pup skin inflammation in interleukin-10 deficient mice. J Dermatol Sci 72:225–232PubMedCrossRef

23.

Song J, Cheon SY, Jung W, Lee WT, Lee JE (2014) Resveratrol induces the expression of interleukin-10 and brain-derived neurotrophic factor in BV2 microglia under hypoxia. Int J Mol Sci 15:15512–15529PubMedCentralPubMedCrossRef

24.

Liu X, Li X, Zhang N, Wen X (2015) Engineering β-cell islets or islet-like structures for type 1 diabetes treatment. Med Hypotheses 85:82–84PubMedCrossRef

25.

Kanazawa M, Kawamura K, Takahashi T et al (2015) Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke. Brain 138:1932–1948PubMedCrossRef

26.

Bereiter-Hahn J, Bernd A, Beschmann H et al (2014) Cellular responses to egg-oil (charismon©). Acta Medica (Hradec Kralove) 57:41–48CrossRef

27.

Cheng P, Kuang F, Zhang H, Ju G, Wang J (2014) Beneficial effects of thymosin β4 on spinal cord injury in the rat. Neuropharmacology 85:408–416PubMedCrossRef

28.

Maftei D, Marconi V, Florenzano F et al (2014) Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals. Br J Pharmacol 171:4850–4865PubMedCentralPubMedCrossRef

29.

Kant V, Gopal A, Pathak NN, Kumar P, Tandan SK, Kumar D (2014) Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats. Int Immunopharmacol 20:322–330PubMedCrossRef

30.

Driesen RB, Nagaraju CK, Abi-Char J et al (2014) Reversible and irreversible differentiation of cardiac fibroblasts. Cardiovasc Res 101:411–422PubMedCentralPubMedCrossRef

31.

Hokenson MA, Wang Y, Hawwa RL, Huang Z, Sharma S, Sanchez-Esteban J (2013) Reduced IL-10 production in fetal type II epithelial cells exposed to mechanical stretch is mediated via activation of IL-6-SOCS3 signaling pathway. PLoS One 8:e59598

32.

van de Vyver M, Myburgh KH (2012) Cytokine and satellite cell responses to muscle damage: interpretation and possible confounding factors in human studies. J Muscle Res Cell Motil 33:177–185PubMedCentralPubMedCrossRef

33.

Cheng SB, Sharma S (2015) Interleukin-10: a pleiotropic regulator in pregnancy. Am J Reprod Immunol 73:487–500PubMedCrossRef

34.

Lima Nda S, de Oliveira E, da Silva AP, Maia Lde A, de Moura EG, Lisboa PC (2014) Effects of Ilex paraguariensis (yerba mate) treatment on leptin resistance and inflammatory parameters in obese rats primed by early weaning. Life Sci 115:29–35PubMedCrossRef

35.

Bakdash G, van Capel TM, Mason LM, Kapsenberg ML, de Jong EC (2014) Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells. Vaccine 32:6294–6302PubMedCrossRef

36.

Canali R, Natarelli L, Leoni G et al (2014) Vitamin C supplementation modulates gene expression in peripheral blood mononuclear cells specifically upon an inflammatory stimulus: a pilot study in healthy subjects. Genes Nutr 9:390PubMedCentralPubMedCrossRef

37.

Myles IA, Pincus NB, Fontecilla NM, Datta SK (2014) Effects of parental omega-3 fatty acid intake on offspring microbiome and immunity. PLoS One 9:e87181

38.

Kuo SM, Merhige PM, Hagey LR (2013) The effect of dietary prebiotics and probiotics on body weight, large intestine indices, and fecal bile acid profile in wild type and IL10−/− mice. PLoS One 8:e60270

39.

Fan MZ, Archbold T, Lackeyram D, Liu Q, Mine Y, Paliyath G (2012) Consumption of guar gum and retrograded high-amylose corn resistant starch increases IL-10 abundance without affecting pro-inflammatory cytokines in the colon of pigs fed a high-fat diet. J Anim Sci 90(Suppl 4):278–280PubMedCrossRef

40.

Kainonen E, Rautava S, Isolauri E (2013) Immunological programming by breast milk creates an anti-inflammatory cytokine milieu in breast-fed infants compared to formula-fed infants. Br J Nutr 109:1962–1970PubMedCrossRef

41.

Chernyavsky AI, Galitovskiy V, Shchepotin IB, Grando SA (2014) Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes. Biomed Res Int 2014:609086. doi:10.1155/2014/609086

42.

Hazlett LD, Jiang X, McClellan SA (2014) IL-10 function, regulation, and in bacterial keratitis. J Ocul Pharmacol Ther 30:373–380PubMedCentralPubMedCrossRef

43.

Kominsky DJ, Campbell EL, Ehrentraut SF et al (2014) IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J Immunol 192:1267–1276PubMedCentralPubMedCrossRef

44.

Ouyang W, Rutz S, Crellin NK, Valdez PA, Hymowitz SG (2011) Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol 29:71–109PubMedCrossRef

45.

Balaji S, King A, Marsh E et al (2015) The role of interleukin-10 and hyaluronan in murine fetal fibroblast function in vitro: implications for recapitulating fetal regenerative wound healing. PLoS One 10:e0124302

46.

Fujioka K, Kishida T, Ejima A et al (2015) Inhibition of osteoclastogenesis by osteoblast-like cells genetically engineered to produce interleukin-10. Biochem Biophys Res Commun 456:785–791PubMedCrossRef

47.

Shi J, Wan Y, Shi S et al (2015) Expression, purification, and characterization of scar tissue neovasculature endothelial cell-targeted rhIL10 in Escherichia coli. Appl Biochem Biotechnol 175:625–634PubMedCrossRef

48.

Kim HY, Cha HJ, Kim HS (2015) CCL5 upregulates IL-10 expression and partially mediates the antihypertensive effects of IL-10 in the vascular smooth muscle cells of spontaneously hypertensive rats. Hypertens Res. doi:10.1038/hr.2015.62

49.

Peake JM, Della Gatta P, Suzuki K, Nieman DC (2014) Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects. Exerc Immunol Rev 21:8–25

50.

Park JH, Kwon JG, Kim SJ et al (2015) Alterations of colonic contractility in an interleukin-10 knockout mouse model of inflammatory bowel disease. J Neurogastroenterol Motil 21:51–61PubMedCentralPubMedCrossRef

51.

Villalta SA, Rosenthal W, Martinez L et al (2014) Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med 6(258):258ra142

52.

da Silva MD, Bobinski F, Sato KL, Kolker SJ, Sluka KA, Santos AR (2015) IL-10 cytokine released from M2 macrophages is crucial for analgesic and anti-inflammatory effects of acupuncture in a model of inflammatory muscle pain. Mol Neurobiol 51:19–31PubMedCrossRefPubMedCentral

53.

Amantea D, Micieli G, Tassorelli C et al (2015) Rational modulation of the innate immune system for neuroprotection in ischemic stroke. Front Neurosci 9:147PubMedCentralPubMedCrossRef

54.

Yang S, Gao L, Lu F et al (2015) Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death. J Neuroinflammation 12:33PubMedCentralPubMedCrossRef

55.

Villacampa N, Almolda B, Vilella A, Campbell IL, González B, Castellano B (2015) Astrocyte-targeted production of IL-10 induces changes in microglial reactivity and reduces motor neuron death after facial nerve axotomy. Glia 63:1166–1184PubMedCrossRef

56.

Almolda B, de Labra C, Barrera I et al (2015) Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10. Brain Behav Immun 45:80–97PubMedCrossRef

57.

Lewkowicz N, Klink M, Mycko MP, Lewkowicz P (2013) Neutrophil–CD4+CD25+ T regulatory cell interactions: a possible new mechanism of infectious tolerance. Immunobiology 218:455–464PubMedCrossRef

58.

Bouabe H, Liu Y, Moser M, Bösl MR, Heesemann J (2011) Novel highly sensitive IL-10-beta-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo. J Immunol 187:3165–3176PubMedCrossRef

59.

Olivier M, Foret B, Le Vern Y, Kerboeuf D, Guilloteau LA (2013) Plasticity of migrating CD1b+ and CD1b- lymph dendritic cells in the promotion of Th1, Th2 and Th17 in response to Salmonella and helminth secretions. PLoS One 8:e79537

60.

Filbey KJ, Grainger JR, Smith KA et al (2014) Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunol Cell Biol 92:436–448PubMedCentralPubMedCrossRef

61.

Gopinathan U, Brusletto BS, Olstad OK et al (2015) IL-10 immunodepletion from meningococcal sepsis plasma induces extensive changes in gene expression and cytokine release in stimulated human monocytes. Innate Immun 21:429–449PubMedCrossRef

62.

Fontaine M, Planel S, Peronnet E et al (2014) S100A8/A9 mRNA induction in an ex vivo model of endotoxin tolerance: roles of IL-10 and IFNγ. PLoS One 9:e100909

63.

Kim JH, Oh SJ, Ahn S, Chung DH (2014) IFN-γ-producing NKT cells exacerbate sepsis by enhancing C5a generation via IL-10-mediated inhibition of CD55 expression on neutrophils. Eur J Immunol 44:2025–2035PubMedCrossRef

64.

Metenou S, Nutman TB (2013) Regulatory T cell subsets in filarial infection and their function. Front Immunol 4:305PubMedCentralPubMedCrossRef

65.

Broen K, Brustoski K, Engelmann I, Luty AJ (2007) Placental Plasmodium falciparum infection: causes and consequences of in utero sensitization to parasite antigens. Mol Biochem Parasitol 151:1–8PubMedCrossRef

66.

de Souza SM, Vieira PM, Roatt BM et al (2014) Dogs infected with the blood trypomastigote form of Trypanosoma cruzi display an increase expression of cytokines and chemokines plus an intense cardiac parasitism during acute infection. Mol Immunol 58:92–97PubMedCrossRef

67.

Mingomataj EÇ, Xhixha F, Gjata E (2006) Helminthes can protect themselves against rejection inhibiting hostile respiratory allergy symptoms. Allergy 61:400–406PubMedCrossRef

68.

Bakiri AH, Mingomataj EÇ (2010) Parasites-induced skin allergy: a strategic manipulation of the host immunity. J ClinMed Res 2:247–255

69.

Bakiri AH, Mingomataj EÇ (2011) Urticaria as symptom of parasite migration through the biological barriers. Open Allergy J 4:1–7CrossRef

70.

Pils MC, Bleich A, Prinz I et al (2011) Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10. Inflamm Bowel Dis 17:2038–2046PubMedCrossRef

71.

Li B, Alli R, Vogel P, Geiger TL (2014) IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis. Mucosal Immunol 7:869–878PubMedCentralPubMed

72.

Hang L, Blum AM, Setiawan T, Urban JP Jr, Stoyanoff KM, Weinstock JV (2013) Heligmosomoides polygyrus bakeri infection activates colonic Foxp3+ T cells enhancing their capacity to prevent colitis. J Immunol 191:1927–1934PubMedCentralPubMedCrossRef

73.

Richter K, Perriard G, Behrendt R et al (2013) Macrophage and T cell produced IL-10 promotes viral chronicity. PLoS Pathog 9:e1003735

74.

Ng SS, Li A, Pavlakis GN, Ozato K, Kino T (2013) Viral infection increases glucocorticoid-induced interleukin-10 production through ERK-mediated phosphorylation of the glucocorticoid receptor in dendritic cells: potential clinical implications. PLoS One 8:e63587

75.

Zou Q, Wu B, Xue J et al (2014) CD8+ Treg cells suppress CD8+ T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection. Eur J Immunol 44:103–114PubMedCentralPubMedCrossRef

76.

Das A, Ellis G, Pallant C et al (2012) IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection. J Immunol 189:3925–3935PubMedCentralPubMedCrossRef

77.

Stanisic DI, Cutts J, Eriksson E et al (2014) γδ T cells and CD14+ monocytes are predominant cellular sources of cytokines and chemokines associated with severe malaria. J Infect Dis 210:295–305PubMedCrossRef

78.

Regidor-Cerrillo J, Arranz-Solís D, Benavides J et al (2014) Neospora caninum infection during early pregnancy in cattle: how the isolate influences infection dynamics, clinical outcome and peripheral and local immune responses. Vet Res 45:10PubMedCentralPubMedCrossRef

79.

Hakimi H, Zare-Bidaki M, Zainodini N, Assar S, Arababadi MK (2014) Significant roles played by IL-10 in chlamydia infections. Inflammation 37:818–823PubMedCrossRef

80.

Babu S, Nutman TB (2013) Immunology of lymphatic filariasis. Parasite Immunol 36:338–346CrossRef

81.

Schwarz T, Remer KA, Nahrendorf W et al (2013) T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine. PLoS Pathog 9:e1003476

82.

Boeuf PS, Loizon S, Awandare GA et al (2012) Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia. Malar J 11:253PubMedCentralPubMedCrossRef

83.

Wang X, Liu F, Zhou S et al (2012) Partial regulatory T cell depletion prior to schistosomiasis vaccination does not enhance the protection. PLoS One 7:e40359

84.

Niikura M, Inoue S, Kobayashi F (2011) Role of interleukin-10 in malaria: focusing on coinfection with lethal and nonlethal murine malaria parasites. J Biomed Biotechnol 2011:383962. doi:10.1155/2011/383962

85.

Arndts K, Specht S, Debrah AY et al (2014) Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels. PLoS Negl Trop Dis 8:e2679

86.

Wagage S, John B, Krock BL et al (2014) The aryl hydrocarbon receptor promotes IL-10 production by NK cells. J Immunol 192:1661–1670PubMedCentralPubMedCrossRef

87.

Hurdayal R, Nieuwenhuizen NE, Revaz-Breton M et al (2013) Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection. PLoS Pathog 9:e1003699

88.

Huang B, Huang S, Chen Y et al (2013) Mast cells modulate acute toxoplasmosis in murine models. PLoS One 8:e77327

89.

Sousa LM, Carneiro MB, Resende ME et al (2014) Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB/c mice. Parasite Immunol 36:13–31PubMedCentralPubMedCrossRef

90.

Carvalho-Costa TM, Mendes MT, da Silva MV et al (2015) Immunosuppressive effects of Amblyomma cajennense tick saliva on murine bone marrow-derived dendritic cells. Parasit Vector 8:22CrossRef

91.

Huang L, Gebreselassie NG, Gagliardo LF et al (2014) Eosinophil-derived IL-10 supports chronic nematode infection. J Immunol 193:4178–4187PubMedCentralPubMedCrossRef

92.

Kulcsar KA, Baxter VK, Greene IP, Griffin DE (2014) Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis. Proc Natl Acad Sci U S A 111:16053–16058PubMedCentralPubMedCrossRef

93.

Hoffmann O, Rung O, Held J et al (2015) Lymphocytes modulate innate immune responses and neuronal damage in experimental meningitis. Infect Immun 83:259–267PubMedCentralPubMedCrossRef

94.

Akdis M, Akdis CA (2014) Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol 133:621–631PubMedCrossRef

95.

Incorvaia C (2013) Preventive capacity of allergen immunotherapy on the natural history of allergy. J Prev Med Hyg 54:71–74PubMedPubMedCentral

96.

Soyka MB, Holzmann D, Akdis CA (2012) Regulatory cells in allergen-specific immunotherapy. Immunotherapy 4:389–396PubMedCrossRef

97.

Yamanaka K, Nakanishi T, Watanabe J et al (2014) Continuous high-dose antigen exposure preferentially induces IL-10, but intermittent antigen exposure induces IL-4. Exp Dermatol 23:63–65PubMedCrossRef

98.

Matsuoka T, Shamji MH, Durham SR (2013) Allergen immunotherapy and tolerance. Allergol Int 62:403–413PubMedCrossRef

99.

Getts DR, McCarthy DP, Miller SD (2013) Exploiting apoptosis for therapeutic tolerance induction. J Immunol 191:5341–5346PubMedCrossRef

100.

Platts-Mills TA, Woodfolk JA (2011) Allergens and their role in the allergic immune response. Immunol Rev 242:51–68PubMedCrossRef

101.

Shi Y, Jin Y, Guo W, Chen L, Liu C, Lv X (2012) Blockage of nerve growth factor modulates T cell responses and inhibits allergic inflammation in a mouse model of asthma. Inflamm Res 61:1369–1378PubMedCrossRef

102.

Escobar A, Aguirre A, Guzmán MA et al (2014) Tolerogenic dendritic cells derived from donors with natural rubber latex allergy modulate allergen-specific T-cell responses and IgE production. PLoS One 9:e85930

103.

Asher I, Mahlab-Guri K, Sthoeger Z (2013) The immunological mechanisms contributing to the clinical efficacy of allergen specific immunotherapy (SIT) in allergic diseases. Harefuah 152:529–533 [in Hebrew]PubMed

104.

Payne NL, Sun G, McDonald C et al (2013) Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity. Brain Behav Immun 30:103–114PubMedCrossRef

105.

Fitzgerald DC, Fonseca-Kelly Z, Cullimore ML et al (2013) Independent and interdependent immunoregulatory effects of IL-27, IFN-β, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis. J Immunol 190:3225–3234PubMedCrossRef

106.

Sonderegger FL, Ma Y, Maylor-Hagan H et al (2012) Localized production of IL-10 suppresses early inflammatory cell infiltration and subsequent development of IFN-γ-mediated Lyme arthritis. J Immunol 188:1381–1393PubMedCentralPubMedCrossRef

107.

Alghasham A, Rasheed Z (2014) Therapeutic targets for rheumatoid arthritis: progress and promises. Autoimmunity 47:77–94PubMedCrossRef

108.

Sattler S, Ling GS, Xu D et al (2014) IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut. J Autoimmun 50:107–122PubMedCentralPubMedCrossRef

109.

Toomey CB, Cauvi DM, Pollard KM (2014) The role of decay accelerating factor in environmentally induced and idiopathic systemic autoimmune disease. Autoimmune Dis 2014:452853. doi:10.1155/2014/452853

110.

El-Shitany NA, El-Bastawissy EA, El-Desoky K (2014) Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism. Int Immunopharmacol 19:290–299PubMedCrossRef

111.

Franco A, Touma R, Song Y et al (2014) Specificity of regulatory T cells that modulate vascular inflammation. Autoimmunity 47:95–104PubMedCrossRef

112.

Di Caro V, Phillips B, Engman C, Harnaha J, Trucco M, Giannoukakis N (2014) Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice. PLoS One 9:e83575

113.

Toubi E, Nussbaum S, Staun-Ram E et al (2012) Laquinimod modulates B cells and their regulatory effects on T cells in multiple sclerosis. J Neuroimmunol 251:45–54PubMedCrossRef

114.

Shi L, Bi M, Yang R et al (2014) Defective expression of regulatory B cells in iodine-induced autoimmune thyroiditis in non-obese diabetic H-2(h4) mice. J Endocrinol Invest 37:43–50PubMedCrossRef

115.

Yang X, Yang J, Chu Y, et al (2014) T follicular helper cells and regulatory B cells dynamics in systemic lupus erythematosus. PLoS One 9:e88441

116.

Rodríguez-Carrio J, de Paz B, López P et al (2014) IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients. PLoS One 9:e86069

117.

Björkbacka H, Fredrikson GN, Nilsson J (2013) Emerging biomarkers and intervention targets for immune-modulation of atherosclerosis - a review of the experimental evidence. Atherosclerosis 227:9–17PubMedCrossRef

118.

Itakura E, Huang RR, Wen DR, Paul E, Wünsch PH, Cochran AJ (2011) IL-10 expression by primary tumor cells correlates with melanoma progression from radial to vertical growth phase and development of metastatic competence. Mod Pathol 24:801–809PubMedCentralPubMedCrossRef

119.

Brooks N, Stojanovska L, Grant P, Apostolopoulos V, McDonald CF, Pouniotis DS (2012) Characterization of blood monocyte phenotype in patients with endometrial cancer. Int J Gynecol Cancer 22:1500–1508PubMed

120.

Sideras K, Braat H, Kwekkeboom J et al (2013) Review: role of the immune system in pancreatic cancer progression and immune modulating treatment strategies. Cancer Treat Rev 40:513–522PubMedCrossRef

121.

Ooi YC, Tran P, Ung N et al (2014) The role of regulatory T-cells in glioma immunology. Clin Neurol Neurosurg 119:125–132PubMedCrossRef

122.

Yan W, Han P, Zhou Z et al (2014) Netrin-1 induces epithelial-mesenchymal transition and promotes hepatocellular carcinoma invasiveness. Dig Dis Sci 59:1213–1221PubMedCrossRef

123.

Maine CJ, Aziz NH, Chatterjee J et al (2014) Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer. Cancer Immunol Immunother 63:215–224PubMedCrossRef

124.

Miranda-Hernández DF, Franco-Molina MA, Mendoza-Gamboa E (2013) Expression of Foxp3, CD25 and IL-2 in the B16F10 cancer cell line and melanoma is correlated with tumor growth in mice. Oncol Lett 6:1195–1200PubMedCentralPubMed

125.

Goswami KK, Barik S, Banerjee S et al (2013) Supraglottic laryngeal tumor microenvironmental factors facilitate STAT3 dependent pro-tumorigenic switch in tumor associated macrophages to render utmost immune evasion. Immunol Lett 156:7–17PubMedCrossRef

126.

Nishioka C, Ikezoe T, Yang J et al (2014) CD82 regulates STAT5/IL-10 and supports survival of acute myelogenous leukemia cells. Int J Cancer 134:55–64PubMedCrossRef

127.

van de Ven R, Lindenberg JJ, Oosterhoff D, de Gruijl TD (2013) Dendritic cell plasticity in tumor-conditioned skin: CD14+ cells at the cross-roads of immune activation and suppression. Front Immunol 4:403PubMedCentralPubMed

128.

Orsini G, Legitimo A, Failli A et al (2013) Defective generation and maturation of dendritic cells from monocytes in colorectal cancer patients during the course of disease. Int J Mol Sci 14:22022–22041PubMedCentralPubMedCrossRef

129.

Scurr M, Ladell K, Besneux M et al (2014) Highly prevalent colorectal cancer-infiltrating LAP(+) Foxp3(−) T cells exhibit more potent immunosuppressive activity than Foxp3(+) regulatory T cells. Mucosal Immunol 7:428–439PubMedCentralPubMedCrossRef

130.

Marçais A, Viel S, Grau M, Henry T, Marvel J, Walzer T (2013) Regulation of mouse NK cell development and function by cytokines. Front Immunol 4:450PubMedCentralPubMedCrossRef

131.

Wang LX, Talebian F, Liu JQ, Khattabi M, Yu L, Bai XF (2012) IL-10 contributes to the suppressive function of tumour-associated myeloid cells and enhances myeloid cell accumulation in tumours. Scand J Immunol 75:273–281PubMedCentralPubMedCrossRef

132.

Zhang Y, Morgan R, Podack ER, Rosenblatt J (2013) B cell regulation of anti-tumor immune response. Immunol Res 57:115–124PubMedCrossRef

133.

Schaer DA, Budhu S, Liu C et al (2013) GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability. Cance Immunol Res 1:320–331CrossRef

134.

Abraham RM, Zhang Q, Odum N, Wasik MA (2011) The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma. Cancer Biol Ther 12:1019–1022PubMedCentralPubMedCrossRef

135.

Mumm JB, Oft M (2013) Pegylated IL-10 induces cancer immunity: the surprising role of IL-10 as a potent inducer of IFN-γ-mediated CD8(+) T cell cytotoxicity. Bioessays 35:623–631PubMedCrossRef

136.

Chen L, Zhou S, Qin J et al (2013) Combination of SLC administration and Tregs depletion is an attractive strategy for targeting hepatocellular carcinoma. Mol Cancer 12:153PubMedCentralPubMedCrossRef

137.

Yang Y, Hou J, Lin Z et al (2014) Attenuated Listeria monocytogenes as a cancer vaccine vector for the delivery of CD24, a biomarker for hepatic cancer stem cells. Cell Mol Immunol 11:184–196PubMedCentralPubMedCrossRef

138.

Chiang CL, Kandalaft LE, Tanyi J et al (2013) A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside. Clin Cancer Res 19:4801–4815PubMedCentralPubMedCrossRef

139.

Sung WW, Lee H (2013) The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma. Oncoimmunol 2:e25854

140.

Kim OH, Kang GH, Noh H et al (2013) Proangiogenic TIE2(+)/CD31 (+) macrophages are the predominant population of tumor-associated macrophages infiltrating metastatic lymph nodes. Mol Cells 36:432–438PubMedCentralPubMedCrossRef

141.

Dennis KL, Blatner NR, Gounari F, Khazaie K (2013) Current status of interleukin-10 and regulatory T-cells in cancer. Curr Opin Oncol 25:637–645PubMedCentralPubMedCrossRef

142.

Gower RM, Boehler RM, Azarin SM, Ricci CF, Leonard JN, Shea LD (2014) Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Biomaterials 35:2024–2031PubMedCentralPubMedCrossRef

143.

Le Texier L, Thebault P, Carvalho-Gaspar M et al (2012) Immunoregulatory function of IL-27 and TGF-β1 in cardiac allograft transplantation. Transplantation 94:226–233PubMedCentralPubMedCrossRef

144.

Uchiyama M, Jin X, Zhang Q et al (2012) Danazol induces prolonged survival of fully allogeneic cardiac grafts and maintains the generation of regulatory CD4(+) cells in mice. Transpl Int 25:357–365PubMedCrossRef

145.

Brikci-Nigassa L, Matsuyama M, Hase T et al (2012) Prope tolerance to heart allografts in mice associated with persistence of donor interleukin-10-transduced stem cells. Transplantation 93:761–768PubMedCrossRef

146.

Kant CD, Akiyama Y, Tanaka K et al (2013) Primary vascularization of allografts governs their immunogenicity and susceptibility to tolerogenesis. J Immunol 191:1948–1956PubMedCentralPubMedCrossRef

147.

Haykal S, Zhou Y, Marcus P et al (2013) The effect of decellularization of tracheal allografts on leukocyte infiltration and of recellularization on regulatory T cell recruitment. Biomaterials 34:5821–5832PubMedCrossRef

148.

Uchiyama M, Jin X, Matsuda H et al (2014) An agonistic anti-BTLA mAb (3C10) induced generation of IL-10-dependent regulatory CD4+ T cells and prolongation of murine cardiac allograft. Transplantation 97:301–309PubMedCrossRef

149.

Charles R, Chou HS, Wang L, Fung JJ, Lu L, Qian S (2013) Human hepatic stellate cells inhibit T-cell response through B7-H1 pathway. Transplantation 96:17–24PubMedCentralPubMedCrossRef

150.

Macdonald KP, Le Texier L, Zhang P et al (2014) Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10. J Immunol 192:3180–3189PubMedCentralPubMedCrossRef

151.

Jaskula E, Lange A, Dlubek D, Polish Donor‐Recipient Matching Group et al (2013) IL-10 promoter polymorphisms influence susceptibility to aGvHD and are associated with proportions of CD4+FoxP3+ lymphocytes in blood after hematopoietic stem cell transplantation. Tissue Antigens 82:387–396PubMedCrossRef

152.

Li CJ, Li L, Lin L et al (2014) Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR genetic polymorphisms on tacrolimus metabolism in Chinese renal transplant recipients. PLoS One 9:e86206

153.

Goode I, Xu H, Ildstad ST (2014) Regulatory B cells: the new “it” cell. Transplant Proc 46:3–8PubMedCrossRef

154.

Dziodzio T, Biebl M, Pratschke J (2014) Impact of brain death on ischemia/reperfusion injury in liver transplantation. Curr Opin Organ Transplant 19:108–114PubMedCrossRef

155.

Vereyken EJ, Kraaij MD, Baan CC et al (2013) A shift towards pro-inflammatory CD16+ monocyte subsets with preserved cytokine production potential after kidney transplantation. PLoS One 8:e70152

156.

McDaniel DO, Rigney DA, McDaniel KY et al (2013) Early expression profile of inflammatory markers and kidney allograft status. Transplant Proc 45:1520–1523PubMedCrossRef

157.

Sklavos MM, Coudriet GM, Delmastro M et al (2013) Administration of a negative vaccination induces hyporesponsiveness to islet allografts. Cell Transplant 22:1147–1155PubMedCentralPubMedCrossRef

158.

Haugaa H, Thorgersen EB, Pharo A et al (2012) Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts. Liver Transpl 18:1421–1429PubMedCrossRef

159.

Levy O, Zhao W, Mortensen LJ et al (2013) mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation. Blood 122:e23–e32PubMedCentralPubMedCrossRef

160.

Wang C, Yu X, Cao Q et al (2013) Characterization of murine macrophages from bone marrow, spleen and peritoneum. BMC Immunol 14:6PubMedCentralPubMedCrossRef

161.

Grimstad Ø, Sandanger Ø, Ryan L et al (2011) Cellular sources and inducers of cytokines present in acute wound fluid. Wound Repair Regen 19:337–347PubMedCrossRef

162.

Castro-Manrreza ME, Mayani H, Monroy-García A et al (2014) Human mesenchymal stromal cells from adult and neonatal sources: a comparative in vitro analysis of their immunosuppressive properties against T cells. Stem Cells Dev 23:1217–1232PubMedCentralPubMedCrossRef

163.

Chan CS, Ming-Lum A, Golds GB, Lee SJ, Anderson RJ, Mui AL (2012) Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-α translation through a SHIP1-dependent pathway. J Biol Chem 287:38020–38027PubMedCentralPubMedCrossRef

164.

Deng B, Wehling-Henricks M, Villalta SA, Wang Y, Tidball JG (2012) IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration. J Immunol 189:3669–3680PubMedCentralPubMedCrossRef

165.

Medeiros MM, da Silva HB, Reis AS et al (2013), Liver accumulation of plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses. PLoS One 8:e81409

166.

Yan G, Xi Y, Xu S et al (2013) Inhibition of accelerated rejection mediated by alloreactive CD4⁺ memory T cells and prolonged allograft survival by arsenic trioxide. Immunol Invest 42:438–454PubMedCrossRef

167.

Pleidrup J, Dalgaard TS, Norup LR et al (2014) Ascaridia galli infection influences the development of both humoral and cell-mediated immunity after Newcastle Disease vaccination in chickens. Vaccine 32:383–392PubMedCrossRef

168.

Kaiser F, Steptoe A, Thompson S, Henderson B (2014) Monocyte cytokine synthesis in response to extracellular cell stress proteins suggests these proteins exhibit network behaviour. Cell Stress Chaperones 19:135–144PubMedCentralPubMedCrossRef

169.

Ghasemi H, Ghazanfari T, Yaraee R, Owlia P, Hassan ZM, Faghihzadeh S (2012) Roles of IL-10 in ocular inflammations: a review. Ocul Immunol Inflamm 20:406–418PubMedCrossRef

170.

Dinh QT, Mingomataj E, Quarcoo D et al (2005) Airway allergic inflammation induces tachykinin peptides expression in vagal sensory neurons innervating mouse airways. Clin Exp Allergy 35:820–825PubMedCrossRef

Titel: Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response
verfasst von: Ervin Ç. Mingomataj
Alketa H. Bakiri
Publikationsdatum: 01.02.2016
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 1/2016
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-015-8514-7

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Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response

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