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Endocrine

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01.02.2013 | Editorial

TLR-10 polymorphism and papillary thyroid cancer: one more SNP to consider?

verfasst von: Myriem Boufraqech, Catsim Fassassi, Electron Kebebew

Erschienen in: Endocrine | Ausgabe 1/2013

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Excerpt

Activated toll-like receptor (TLR) signaling pathway has been reported in several endocrine neoplasms and has been found to be associated with the upregulation of proinflammatory cytokines. These cytokines are widely known as critical mediators of tumorigenesis. The stimulation of antitumor immunity through the activation of the TLR pathway can lead to the inhibition of the carcinogenesis process. However, TLRs have been considered as putative therapeutic target in various human cancers. A chronic inflammation in the absence of infection induces oxidative stress, DNA damage, and tissue damage promoting tumorigenesis. Thus, TLRs can be viewed as having a double-edged sword function. …

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Titel: TLR-10 polymorphism and papillary thyroid cancer: one more SNP to consider?
verfasst von: Myriem Boufraqech
Catsim Fassassi
Electron Kebebew
Publikationsdatum: 01.02.2013
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2013
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-012-9827-4

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TLR-10 polymorphism and papillary thyroid cancer: one more SNP to consider?

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