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Erschienen in: Endocrine 1/2013

01.08.2013 | Original Article

Regulatory T cells and plasmacytoid dendritic cells contribute to the immune escape of papillary thyroid cancer coexisting with multinodular non-toxic goiter

verfasst von: Hang Yu, Xiaomei Huang, Xiaosun Liu, Hailong Jin, Ge’er Zhang, Qing Zhang, Jiren Yu

Erschienen in: Endocrine | Ausgabe 1/2013

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Abstract

Immunosuppressive lymphocytes, such as regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs), play crucial roles in tumor escape. To investigate the roles of Tregs and pDCs in papillary thyroid cancer (PTC) plus multinodular non-toxic goiter (MNG), thyroid tissue and blood samples from 30 patients with PTC plus MNG and 30 MNG alone were analyzed for CD4+ T cell, CD8+ T cell, FoxP3+ Treg, ICOS+FoxP3+ Treg, and pDC numbers by immunohistochemistry (IHC), immunofluorescence, and flow cytometry. Plasma concentration of the cytokines interleukin 10 (IL-10) and transforming growth factor β (TGF-β) were measured by enzyme-linked immunosorbent assay as well. Both in thyroid tissue and peripheral blood, the numbers of Foxp3+ Treg were significantly higher in patients with PTC plus MNG compared to patients with MNG alone; and as a prognostic marker, ICOS+Foxp3+ Tregs represent a stronger predictor of disease progression than the total numbers of Foxp3+ Tregs. Furthermore, a positive correlation between pDC and ICOS+Foxp3+ Treg numbers in tissue of patients with PTC plus MNG was observed, suggesting that PTC-derived pDCs may induce the differentiation of naive CD4+ T cells into ICOS+Foxp3+Tregs. This may be one of the mechanisms underlying tumor escape in PTC plus MNG patients. Our results suggest that Tregs and pDCs together contribute to the tumor escape in patients with PTC plus MNG.
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Metadaten
Titel
Regulatory T cells and plasmacytoid dendritic cells contribute to the immune escape of papillary thyroid cancer coexisting with multinodular non-toxic goiter
verfasst von
Hang Yu
Xiaomei Huang
Xiaosun Liu
Hailong Jin
Ge’er Zhang
Qing Zhang
Jiren Yu
Publikationsdatum
01.08.2013
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 1/2013
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-012-9853-2

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