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Erschienen in: Endocrine 3/2015

01.12.2015 | Original Article

The association with Turner syndrome significantly affects the course of Hashimoto’s thyroiditis in children, irrespective of karyotype

verfasst von: Tommaso Aversa, Maria Francesca Messina, Laura Mazzanti, Mariacarolina Salerno, Alessandro Mussa, Maria Felicia Faienza, Emanuela Scarano, Filippo De Luca, Malgorzata Wasniewska

Erschienen in: Endocrine | Ausgabe 3/2015

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Abstract

Only few studies have investigated to now whether the association with Turner syndrome (TS) may affect the course of Hashimoto’s thyroiditis (HT) in children. Aim of this study was to ascertain whether the presentation and long-term course of HT in TS children may be characterized by a peculiar and atypical pattern. The clinical and biochemical findings at HT diagnosis in 90 TS children (group A) were compared with those recorded in 449 girls with HT but without TS (group B); in group A patients, thyroid function tests were re-evaluated after a median time interval of 4.9 years. At HT diagnosis median TSH levels and the rate of cases presenting with a thyroid dysfunction picture were significantly lower in group A, irrespective of karyotype abnormalities. In group A only 34.8 % of the girls who had initially presented with euthyroidism remained euthyroid even at re-evaluation, whilst 67.7 % of those who had presented with subclinical hypothyroidism became overtly hypothyroid over time; also such evolutive pattern was irrespective of karyotype abnormalities. (1) In TS girls, HT presents with a milder hormonal pattern, which often deteriorates over time; (2) these biochemical features are not necessarily linked with a specific karyotype.
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Metadaten
Titel
The association with Turner syndrome significantly affects the course of Hashimoto’s thyroiditis in children, irrespective of karyotype
verfasst von
Tommaso Aversa
Maria Francesca Messina
Laura Mazzanti
Mariacarolina Salerno
Alessandro Mussa
Maria Felicia Faienza
Emanuela Scarano
Filippo De Luca
Malgorzata Wasniewska
Publikationsdatum
01.12.2015
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2015
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-014-0513-6

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