Erschienen in:
16.11.2015 | Original Article
Effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction
verfasst von:
Wei-Ren Chen, Xue-Qin Shen, Ying Zhang, Yun-Dai Chen, Shun-Ying Hu, Geng Qian, Jing Wang, Jun-Jie Yang, Zhi-Feng Wang, Feng Tian
Erschienen in:
Endocrine
|
Ausgabe 3/2016
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Abstract
The influence of glucagon-like peptide-1 has been studied in several studies in patients with acute myocardial infarction, but not in patients with non-ST-segment elevation myocardial infarction (NSTEMI). We planned to evaluate the effects of liraglutide on left ventricular function in patients with NSTEMI. A total of 90 patients were randomized 1:1 to receive either liraglutide (0.6 mg for 2 days, 1.2 mg for 2 days, followed by 1.8 mg for 3 days) or placebo for 7 days. Eighty-three patients completed the trial. Transthoracic echocardiography was used to assess left ventricular function. At 3 months, the primary endpoint, the difference in the change in left ventricular ejection fraction between the two groups was +4.7 % (liraglutide vs. placebo 95 % CI +0.7 to +9.2 % P = 0.009) under intention-to-treat analysis. The difference in decrease in serum glycosylated hemoglobin levels was −0.2 % (liraglutide vs. placebo 95 % CI −0.1 to −0.3 %; P < 0.001). Inflammation and oxidative stress improved significantly in the liraglutide group compared to the placebo group. Liraglutide could improve left ventricular function in patients with NSTEMI, making it a potential adjuvant therapy for NSTEMI.