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Erschienen in: Endocrine 1/2017

29.09.2016 | Original Article

Comparison of the therapeutic effects of prednisolone and nonsteroidal anti-inflammatory drugs in patients with subacute thyroiditis

verfasst von: Junko Sato, Toyoyoshi Uchida, Koji Komiya, Hiromasa Goto, Kageumi Takeno, Ruriko Suzuki, Akira Honda, Miwa Himuro, Hirotaka Watada

Erschienen in: Endocrine | Ausgabe 1/2017

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Abstract

Subacute thyroiditis is a transient inflammatory thyroid disease of unknown etiology. The primary goal for treatment is to mitigate inflammation. The aim of this retrospective study was to compare the therapeutic effects of prednisolone and nonsteroidal anti-inflammation drugs in patients with subacute thyroiditis. In this study, 53 consecutive Japanese patients who had been diagnosed with were referred to our hospital for further management. After excluding 11 patients (9 did not need treatment, 2 did not meet the criteria for diagnosis of subacute thyroiditis), the remaining 42 patients were treated either with prednisolone (n = 25) or loxoprofen (n = 17). We compared the time periods required for resolution of clinical symptoms and signs and normalization of thyroid function between the two groups. The mean dose of prednisolone was 15.0 (range, 14–16) mg/day and that of loxoprofen was 180 mg/day. The time period to normalization of thyroid function was comparable between the prednisolone and loxoprofen groups (25, 18–36, vs 32, 21–39 days, p = 0.388). However, the time period for resolution of symptoms was shorter under prednisolone than loxoprofen (7, 7–12 days, vs 21, 14–32 days, p < 0.001). Prednisolone treatment of patients with subacute thyroiditis was superior to nonsteroidal anti-inflammation drugs with regard to resolution of symptoms.
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Literatur
1.
Zurück zum Zitat R.S. Bahn Chair, H.B. Burch, D.S. Cooper, J.R. Garber, M.C. Greenlee, I. Klein, P. Laurberg, I.R. McDougall, V.M. Montori, S.A. Rivkees, D.S. Ross, J.A. Sosa, M.N. Stan, Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid 21(6), 593–646 (2011)CrossRefPubMed R.S. Bahn Chair, H.B. Burch, D.S. Cooper, J.R. Garber, M.C. Greenlee, I. Klein, P. Laurberg, I.R. McDougall, V.M. Montori, S.A. Rivkees, D.S. Ross, J.A. Sosa, M.N. Stan, Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid 21(6), 593–646 (2011)CrossRefPubMed
2.
Zurück zum Zitat M. Yamamoto, S. Saito, K. Kaise, N. Kaise, K. Yoshida, K. Yoshinaga, Changes in thyroid hormones by treatment with aspirin and prednisolone in subacute thyroiditis with hyperthyroidism. Tohoku J. Exp. Med. 127(1), 85–95 (1979)CrossRefPubMed M. Yamamoto, S. Saito, K. Kaise, N. Kaise, K. Yoshida, K. Yoshinaga, Changes in thyroid hormones by treatment with aspirin and prednisolone in subacute thyroiditis with hyperthyroidism. Tohoku J. Exp. Med. 127(1), 85–95 (1979)CrossRefPubMed
3.
Zurück zum Zitat M. Yamamoto, S. Saito, T. Sakurada, H. Fukazawa, K. Yoshida, K. Kaise, N. Kaise, T. Nomura, Y. Itagaki, K. Yonemitsu, K. Yoshinaga, Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis. Clin. Endocrinol. (Oxf) 27(3), 339–344 (1987)CrossRef M. Yamamoto, S. Saito, T. Sakurada, H. Fukazawa, K. Yoshida, K. Kaise, N. Kaise, T. Nomura, Y. Itagaki, K. Yonemitsu, K. Yoshinaga, Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis. Clin. Endocrinol. (Oxf) 27(3), 339–344 (1987)CrossRef
4.
Zurück zum Zitat T. Uchida, R. Suzuki, T. Kasai, H. Onose, K. Komiya, H. Goto, K. Takeno, S. Ishii, J. Sato, A. Honda, Y. Kawano, M. Himuro, E. Yamada, T. Yamada, H. Watada, Cutoff value of thyroid uptake of Tc-pertechnetate to discriminate between Graves' disease and painless thyroiditis: a single center retrospective study. Endocr. J. 63(2), 143–149 (2016)CrossRefPubMed T. Uchida, R. Suzuki, T. Kasai, H. Onose, K. Komiya, H. Goto, K. Takeno, S. Ishii, J. Sato, A. Honda, Y. Kawano, M. Himuro, E. Yamada, T. Yamada, H. Watada, Cutoff value of thyroid uptake of Tc-pertechnetate to discriminate between Graves' disease and painless thyroiditis: a single center retrospective study. Endocr. J. 63(2), 143–149 (2016)CrossRefPubMed
5.
Zurück zum Zitat E. Nishihara, H. Ohye, N. Amino, K. Takata, T. Arishima, T. Kudo, M. Ito, S. Kubota, S. Fukata, A. Miyauchi, Clinical characteristics of 852 patients with subacute thyroiditis before treatment. Intern. Med. 47(8), 725–729 (2008)CrossRefPubMed E. Nishihara, H. Ohye, N. Amino, K. Takata, T. Arishima, T. Kudo, M. Ito, S. Kubota, S. Fukata, A. Miyauchi, Clinical characteristics of 852 patients with subacute thyroiditis before treatment. Intern. Med. 47(8), 725–729 (2008)CrossRefPubMed
6.
Zurück zum Zitat S. Kubota, E. Nishihara, T. Kudo, M. Ito, N. Amino, A. Miyauchi, Initial treatment with 15 mg of prednisolone daily is sufficient for most patients with subacute thyroiditis in Japan. Thyroid 23(3), 269–272 (2013)CrossRefPubMed S. Kubota, E. Nishihara, T. Kudo, M. Ito, N. Amino, A. Miyauchi, Initial treatment with 15 mg of prednisolone daily is sufficient for most patients with subacute thyroiditis in Japan. Thyroid 23(3), 269–272 (2013)CrossRefPubMed
7.
Zurück zum Zitat C.A. Benbassat, D. Olchovsky, G. Tsvetov, I. Shimon, Subacute thyroiditis: clinical characteristics and treatment outcome in fifty-six consecutive patients diagnosed between 1999 and 2005. J. Endocrinol. Invest. 30(8), 631–635 (2007)CrossRefPubMed C.A. Benbassat, D. Olchovsky, G. Tsvetov, I. Shimon, Subacute thyroiditis: clinical characteristics and treatment outcome in fifty-six consecutive patients diagnosed between 1999 and 2005. J. Endocrinol. Invest. 30(8), 631–635 (2007)CrossRefPubMed
8.
Zurück zum Zitat R. Volpe, The management of subacute (DeQuervain's) thyroiditis. Thyroid 3(3), 253–255 (1993)CrossRefPubMed R. Volpe, The management of subacute (DeQuervain's) thyroiditis. Thyroid 3(3), 253–255 (1993)CrossRefPubMed
9.
Zurück zum Zitat F.M. Cunningham, P. Lees, Advances in anti-inflammatory therapy. Br. Vet. J. 150(2), 115–134 (1994)CrossRefPubMed F.M. Cunningham, P. Lees, Advances in anti-inflammatory therapy. Br. Vet. J. 150(2), 115–134 (1994)CrossRefPubMed
Metadaten
Titel
Comparison of the therapeutic effects of prednisolone and nonsteroidal anti-inflammatory drugs in patients with subacute thyroiditis
verfasst von
Junko Sato
Toyoyoshi Uchida
Koji Komiya
Hiromasa Goto
Kageumi Takeno
Ruriko Suzuki
Akira Honda
Miwa Himuro
Hirotaka Watada
Publikationsdatum
29.09.2016
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 1/2017
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-016-1122-3

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