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Erschienen in: Endocrine 2/2020

28.05.2020 | Original Article

Epidemiology of pancreatic neuroendocrine neoplasms: a gender perspective

verfasst von: Giovanna Muscogiuri, Barbara Altieri, Manuela Albertelli, Andrea Dotto, Roberta Modica, Luigi Barrea, Giuseppe Fanciulli, Tiziana Feola, Roberto Baldelli, Rosaria Maddalena Ruggeri, Marco Gallo, Valentina Guarnotta, Pasqualino Malandrino, Erika Messina, Mary Anna Venneri, Elisa Giannetta, Diego Ferone, Annamaria Colao, Antongiulio Faggiano, on behalf of NIKE group

Erschienen in: Endocrine | Ausgabe 2/2020

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Abstract

Purpose

Pancreatic neuroendocrine neoplasms (PNENs) are a group of clinically rare and heterogeneous tumors of the pancreas. Currently there are no studies investigating the gender difference in PNEN susceptibility. Thus, the purpose of this study was aimed at examining how gender shapes risk factors, clinicopathological features, and comorbidities in PNENs.

Methods

The study design consisted of an Italian multicenter, retrospective study. The study included all consecutive patients with PNENs followed at the participating centers. Two hundred and twenty-nine patients (105 males,124 females, age 54 ± 0.98 years) with PNENs were enrolled at the participating centers. The clinicopathological features (age, gender, BMI, histology, tumor size, tumor grade, distant metastasis, hormonal function, and diagnostic circumstances), comorbidities (cardiovascular diseases (CVD), pancreatitis, type 2 diabetes (T2DM), and potential risk factors (smoking and drinking) were included in the analysis.

Results

Females were slightly prevalent (54.15%). PNENs were diagnosed at younger age in females compared to males (p = 0.04). The prevalence of CVD was significantly higher in males than in females (p = 0.006). In the female group, the presence of T2DM was significantly associated with higher tumor grade (p = 0.04) and metastatic disease (p = 0.02). The proportion of smokers and alcohol drinkers was significantly higher in the male group (p < 0.001). No significant gender differences were detected regarding the other parameters included in the analysis.

Conclusions

This study has identified gender differences of PNENs in terms of age at diagnosis, associated comorbidities, and potential risk factors. A gender-tailored approach could become a potential strategy to better understand the natural history of PNENs and improve the effectiveness of PNENs clinical management.
Literatur
9.
Zurück zum Zitat A. Faggiano, P. Ferolla, F. Grimaldi, D. Campana, M. Manzoni, M.V. Davi, A. Bianchi, R. Valcavi, E. Papini, D. Giuffrida, D. Ferone, G. Fanciulli, G. Arnaldi, G.M. Franchi, G. Francia, G. Fasola, L. Crino, A. Pontecorvi, P. Tomassetti, A. Colao, Natural history of gastro-entero-pancreatic and thoracic neuroendocrine tumors. Data from a large prospective and retrospective Italian epidemiological study: the NET management study. J. Endocrinol. Invest. 35(9), 817–823 (2012). https://doi.org/10.3275/8102 CrossRefPubMed A. Faggiano, P. Ferolla, F. Grimaldi, D. Campana, M. Manzoni, M.V. Davi, A. Bianchi, R. Valcavi, E. Papini, D. Giuffrida, D. Ferone, G. Fanciulli, G. Arnaldi, G.M. Franchi, G. Francia, G. Fasola, L. Crino, A. Pontecorvi, P. Tomassetti, A. Colao, Natural history of gastro-entero-pancreatic and thoracic neuroendocrine tumors. Data from a large prospective and retrospective Italian epidemiological study: the NET management study. J. Endocrinol. Invest. 35(9), 817–823 (2012). https://​doi.​org/​10.​3275/​8102 CrossRefPubMed
10.
Zurück zum Zitat A. Faggiano, R. Modica, F. Lo Calzo, L. Camera, V. Napolitano, B. Altieri, F. de Cicco, F. Bottiglieri, F. Sesti, G. Badalamenti, A.M. Isidori, A. Colao, Lanreotide therapy vs active surveillance in MEN1-related pancreatic neuroendocrine tumors <2 centimeters. J. Clin. Endocrinol. Metab. 105(1) (2020). https://doi.org/10.1210/clinem/dgz007 A. Faggiano, R. Modica, F. Lo Calzo, L. Camera, V. Napolitano, B. Altieri, F. de Cicco, F. Bottiglieri, F. Sesti, G. Badalamenti, A.M. Isidori, A. Colao, Lanreotide therapy vs active surveillance in MEN1-related pancreatic neuroendocrine tumors <2 centimeters. J. Clin. Endocrinol. Metab. 105(1) (2020). https://​doi.​org/​10.​1210/​clinem/​dgz007
11.
Zurück zum Zitat R. Valente, A.J. Hayes, S.P. Haugvik, P. Hedenstrom, D. Siuka, E. Korsaeth, D. Kammerer, S.M. Robinson, P. Maisonneuve, G. Delle Fave, B. Lindkvist, G. Capurso, Risk and protective factors for the occurrence of sporadic pancreatic endocrine neoplasms. Endocr. Relat. Cancer 24(8), 405–414 (2017). https://doi.org/10.1530/ERC-17-0040 CrossRefPubMed R. Valente, A.J. Hayes, S.P. Haugvik, P. Hedenstrom, D. Siuka, E. Korsaeth, D. Kammerer, S.M. Robinson, P. Maisonneuve, G. Delle Fave, B. Lindkvist, G. Capurso, Risk and protective factors for the occurrence of sporadic pancreatic endocrine neoplasms. Endocr. Relat. Cancer 24(8), 405–414 (2017). https://​doi.​org/​10.​1530/​ERC-17-0040 CrossRefPubMed
12.
13.
Zurück zum Zitat M. Falconi, B. Eriksson, G. Kaltsas, D.K. Bartsch, J. Capdevila, M. Caplin, B. Kos-Kudla, D. Kwekkeboom, G. Rindi, G. Kloppel, N. Reed, R. Kianmanesh, R.T. Jensen, Vienna Consensus Conference Participants, ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors. Neuroendocrinology 103(2), 153–171 (2016). https://doi.org/10.1159/000443171 M. Falconi, B. Eriksson, G. Kaltsas, D.K. Bartsch, J. Capdevila, M. Caplin, B. Kos-Kudla, D. Kwekkeboom, G. Rindi, G. Kloppel, N. Reed, R. Kianmanesh, R.T. Jensen, Vienna Consensus Conference Participants, ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors. Neuroendocrinology 103(2), 153–171 (2016). https://​doi.​org/​10.​1159/​000443171
14.
Zurück zum Zitat N. Benetatos, J. Hodson, R. Marudanayagam, R.P. Sutcliffe, J.R. Isaac, J. Ayuk, T. Shah, K.J. Roberts, Prognostic factors and survival after surgical resection of pancreatic neuroendocrine tumor with validation of established and modified staging systems. Hepatobiliary Pancreat. Dis. Int, 17(2), 169–175 (2018). https://doi.org/10.1016/j.hbpd.2018.03.002 CrossRefPubMed N. Benetatos, J. Hodson, R. Marudanayagam, R.P. Sutcliffe, J.R. Isaac, J. Ayuk, T. Shah, K.J. Roberts, Prognostic factors and survival after surgical resection of pancreatic neuroendocrine tumor with validation of established and modified staging systems. Hepatobiliary Pancreat. Dis. Int, 17(2), 169–175 (2018). https://​doi.​org/​10.​1016/​j.​hbpd.​2018.​03.​002 CrossRefPubMed
15.
16.
Zurück zum Zitat K. Tsutsumi, T. Ohtsuka, M. Fujino, H. Nakashima, S. Aishima, J. Ueda, S. Takahata, M. Nakamura, Y. Oda, M. Tanaka, Analysis of risk factors for recurrence after curative resection of well-differentiated pancreatic neuroendocrine tumors based on the new grading classification. J. Hepatobiliary Pancreat. Sci. 21(6), 418–425 (2014). https://doi.org/10.1002/jhbp.47 CrossRefPubMed K. Tsutsumi, T. Ohtsuka, M. Fujino, H. Nakashima, S. Aishima, J. Ueda, S. Takahata, M. Nakamura, Y. Oda, M. Tanaka, Analysis of risk factors for recurrence after curative resection of well-differentiated pancreatic neuroendocrine tumors based on the new grading classification. J. Hepatobiliary Pancreat. Sci. 21(6), 418–425 (2014). https://​doi.​org/​10.​1002/​jhbp.​47 CrossRefPubMed
19.
Zurück zum Zitat R.V. Lloyd, R.Y. Osamura, G. Klöppel, J. Rosai, WHO classification of tumours of endocrine organs. In: Press, I. (ed.) WHO Classification of Tumours, vol. 10, p. 355, Lyons, France (2017) R.V. Lloyd, R.Y. Osamura, G. Klöppel, J. Rosai, WHO classification of tumours of endocrine organs. In: Press, I. (ed.) WHO Classification of Tumours, vol. 10, p. 355, Lyons, France (2017)
20.
Zurück zum Zitat World Health Organization, Waist Circumference and Waist–Hip Ratio. Report of a WHO Expert Consultation, Geneva, Switzerland, 8–11 December 2008 (2008) World Health Organization, Waist Circumference and Waist–Hip Ratio. Report of a WHO Expert Consultation, Geneva, Switzerland, 8–11 December 2008 (2008)
22.
Zurück zum Zitat J.C. Yao, M. Hassan, A. Phan, C. Dagohoy, C. Leary, J.E. Mares, E.K. Abdalla, J.B. Fleming, J.N. Vauthey, A. Rashid, D.B. Evans, One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J. Clin. Oncol. 26(18), 3063–3072 (2008). https://doi.org/10.1200/JCO.2007.15.4377 CrossRefPubMed J.C. Yao, M. Hassan, A. Phan, C. Dagohoy, C. Leary, J.E. Mares, E.K. Abdalla, J.B. Fleming, J.N. Vauthey, A. Rashid, D.B. Evans, One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J. Clin. Oncol. 26(18), 3063–3072 (2008). https://​doi.​org/​10.​1200/​JCO.​2007.​15.​4377 CrossRefPubMed
23.
Zurück zum Zitat M.A. De Leon-Nava, K. Nava, G. Soldevila, L. Lopez-Griego, J.R. Chavez-Rios, J.A. Vargas-Villavicencio, J. Morales-Montor, Immune sexual dimorphism: effect of gonadal steroids on the expression of cytokines, sex steroid receptors, and lymphocyte proliferation. J. Steroid Biochem. Mol. Biol. 113(1–2), 57–64 (2009). https://doi.org/10.1016/j.jsbmb.2008.11.003 CrossRefPubMed M.A. De Leon-Nava, K. Nava, G. Soldevila, L. Lopez-Griego, J.R. Chavez-Rios, J.A. Vargas-Villavicencio, J. Morales-Montor, Immune sexual dimorphism: effect of gonadal steroids on the expression of cytokines, sex steroid receptors, and lymphocyte proliferation. J. Steroid Biochem. Mol. Biol. 113(1–2), 57–64 (2009). https://​doi.​org/​10.​1016/​j.​jsbmb.​2008.​11.​003 CrossRefPubMed
26.
Zurück zum Zitat S. Patel, M. Narwari, D. Parekh, V. Shah, Insulinoma: case report and review of diagnostic and treatment modalities. J. Assoc. Physicians India 61(6), 423–426 (2013)PubMed S. Patel, M. Narwari, D. Parekh, V. Shah, Insulinoma: case report and review of diagnostic and treatment modalities. J. Assoc. Physicians India 61(6), 423–426 (2013)PubMed
27.
Zurück zum Zitat L. Barrea, B. Altieri, G. Muscogiuri, D. Laudisio, G. Annunziata, A. Colao, A. Faggiano, S. Savastano, Impact of nutritional status on gastroenteropancreatic neuroendocrine tumors (GEP-NET) aggressiveness. Nutrients 10(12) (2018). https://doi.org/10.3390/nu10121854 L. Barrea, B. Altieri, G. Muscogiuri, D. Laudisio, G. Annunziata, A. Colao, A. Faggiano, S. Savastano, Impact of nutritional status on gastroenteropancreatic neuroendocrine tumors (GEP-NET) aggressiveness. Nutrients 10(12) (2018). https://​doi.​org/​10.​3390/​nu10121854
33.
Zurück zum Zitat G. Capurso, M. Falconi, F. Panzuto, M. Rinzivillo, L. Boninsegna, R. Bettini, V. Corleto, P. Borgia, P. Pederzoli, A. Scarpa, G. Delle Fave, Risk factors for sporadic pancreatic endocrine tumors: a case-control study of prospectively evaluated patients. Am. J. Gastroenterol. 104(12), 3034–3041 (2009). https://doi.org/10.1038/ajg.2009.466 CrossRefPubMed G. Capurso, M. Falconi, F. Panzuto, M. Rinzivillo, L. Boninsegna, R. Bettini, V. Corleto, P. Borgia, P. Pederzoli, A. Scarpa, G. Delle Fave, Risk factors for sporadic pancreatic endocrine tumors: a case-control study of prospectively evaluated patients. Am. J. Gastroenterol. 104(12), 3034–3041 (2009). https://​doi.​org/​10.​1038/​ajg.​2009.​466 CrossRefPubMed
36.
Zurück zum Zitat J.P. Dumanski, C. Rasi, M. Lonn, H. Davies, M. Ingelsson, V. Giedraitis, L. Lannfelt, P.K. Magnusson, C.M. Lindgren, A.P. Morris, D. Cesarini, M. Johannesson, E. Tiensuu Janson, L. Lind, N.L. Pedersen, E. Ingelsson, L.A. Forsberg, Mutagenesis. Smoking is associated with mosaic loss of chromosome Y. Science 347(6217), 81–83 (2015). https://doi.org/10.1126/science.1262092 CrossRefPubMed J.P. Dumanski, C. Rasi, M. Lonn, H. Davies, M. Ingelsson, V. Giedraitis, L. Lannfelt, P.K. Magnusson, C.M. Lindgren, A.P. Morris, D. Cesarini, M. Johannesson, E. Tiensuu Janson, L. Lind, N.L. Pedersen, E. Ingelsson, L.A. Forsberg, Mutagenesis. Smoking is associated with mosaic loss of chromosome Y. Science 347(6217), 81–83 (2015). https://​doi.​org/​10.​1126/​science.​1262092 CrossRefPubMed
Metadaten
Titel
Epidemiology of pancreatic neuroendocrine neoplasms: a gender perspective
verfasst von
Giovanna Muscogiuri
Barbara Altieri
Manuela Albertelli
Andrea Dotto
Roberta Modica
Luigi Barrea
Giuseppe Fanciulli
Tiziana Feola
Roberto Baldelli
Rosaria Maddalena Ruggeri
Marco Gallo
Valentina Guarnotta
Pasqualino Malandrino
Erika Messina
Mary Anna Venneri
Elisa Giannetta
Diego Ferone
Annamaria Colao
Antongiulio Faggiano
on behalf of NIKE group
Publikationsdatum
28.05.2020
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 2/2020
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-020-02331-3

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