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Forensic Science, Medicine and Pathology

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27.09.2016 | Original Article

Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter

verfasst von: Kristina Schwender, Hannah Holtkötter, Kristina Schulze Johann, Alina Glaub, Marianne Schürenkamp, Ulla Sibbing, Sabrina Banken, Mechtild Vennemann, Heidi Pfeiffer, Marielle Vennemann, GeSID Study Group

Erschienen in: Forensic Science, Medicine and Pathology | Ausgabe 4/2016

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Abstract

Purpose

Smoking during pregnancy has long been known as an important risk factor for sudden infant death syndrome (SIDS). However, the precise relationship between the smoking behavior of the mother and SIDS still remains unclear. In this study, the influence of prenatal smoking exposure on the childrens’ DNA methylation state of a CpG island located upstream of the promoter of the growth factor independent 1 (GFI1) gene was analyzed.

Methods

Blood samples of well-defined SIDS cases with non-smoking mothers (n = 11), SIDS cases with smoking mothers during pregnancy (n = 11), and non-SIDS cases (n = 6) were obtained from a previous study and methylation states were determined by bisulfite sequencing.

Results

Significant hypomethylation was observed in this CpG island in SIDS cases with cigarette smoke exposure compared to non-exposed cases. The strongest effect in this CpG island was observed for 49 CpG sites located within a transcription factor binding site. Coding for a transcriptional repressor, GFI1 plays an important role in various developmental processes. Alterations in the GFI1 expression might be linked to various conditions that are known to be associated with SIDS, such as dysregulated hematopoiesis and excessive inflammatory response.

Conclusion

Data obtained in this study show that analysis of methylation states in cases of sudden infant death syndrome might provide a further important piece of knowledge toward understanding SIDS, and should be investigated in further studies.

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Titel: Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter
verfasst von: Kristina Schwender
Hannah Holtkötter
Kristina Schulze Johann
Alina Glaub
Marianne Schürenkamp
Ulla Sibbing
Sabrina Banken
Mechtild Vennemann
Heidi Pfeiffer
Marielle Vennemann
GeSID Study Group
Publikationsdatum: 27.09.2016
Verlag: Springer US
Erschienen in: Forensic Science, Medicine and Pathology / Ausgabe 4/2016
Print ISSN: 1547-769X
Elektronische ISSN: 1556-2891
DOI: https://doi.org/10.1007/s12024-016-9812-y

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Abstract

Purpose

Methods

Results

Conclusion

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Conclusion

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