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01.04.2012 | Immunology in Serbia

The roles of Galectin-3 in autoimmunity and tumor progression

verfasst von: Gordana Radosavljevic, Vladislav Volarevic, Ivan Jovanovic, Marija Milovanovic, Nada Pejnovic, Nebojsa Arsenijevic, Daniel K. Hsu, Miodrag L. Lukic

Erschienen in: Immunologic Research | Ausgabe 1-2/2012

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Abstract

Galectin-3, a unique chimera-type member of the β-galactoside-binding soluble lectin family, is widely expressed in numerous cells. Here, we discuss the role of Galectin-3 in T-cell-mediated inflammatory (auto) immunity and tumor rejection by using Galectin-3-deficient mice and four disease models of human pathology: experimental autoimmune encephalomyelitis (EAE), Con-A-induced hepatitis, multiple low-dose streptozotocin-induced diabetes (MLD-STZ diabetes) and metastatic melanoma. We present evidence which suggest that Galectin-3 plays an important pro-inflammatory role in Con-A-induced hepatitis by promoting the activation of T lymphocytes, NKT cells and DCs, cytokine secretion, prevention of M2 macrophage polarization and apoptosis of mononuclear cells, and it leads to severe liver injury. In addition, experiments in Galectin-3-“knock-out” mice indicate that Galectin-3 is also involved in immune-mediated β-cell damage and is required for diabetogenesis in MLD-STZ model by promoting the expression of IFN-gamma, TNF-alpha, IL-17 and iNOS in immune and accessory effector cells. Next, our data demonstrated that Galectin-3 plays an important disease-exacerbating role in EAE through its multifunctional roles in preventing cell apoptosis and increasing IL-17 and IFN-gamma synthesis, but decreasing IL-10 production. Finally, based on our findings, we postulated that expression of Galectin-3 in the host may also facilitate melanoma metastasis by affecting tumor cell adhesion and modulating anti-melanoma immune response, in particular innate antitumor immunity. Taken together, we discuss the evidence of pro-inflammatory and antitumor activities of Galectin-3 and suggest that Galectin-3 may be an important therapeutic target.

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Titel: The roles of Galectin-3 in autoimmunity and tumor progression
verfasst von: Gordana Radosavljevic
Vladislav Volarevic
Ivan Jovanovic
Marija Milovanovic
Nada Pejnovic
Nebojsa Arsenijevic
Daniel K. Hsu
Miodrag L. Lukic
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Immunologic Research / Ausgabe 1-2/2012
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-012-8286-6

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Springer Medizin

The roles of Galectin-3 in autoimmunity and tumor progression

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Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

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„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

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