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01.06.2010 | ORIGINAL RESEARCH

The Baseline Ratio of Neutrophils to Lymphocytes is Associated with Patient Prognosis in Rectal Carcinoma

verfasst von: Huanran Liu, Ge Liu, Quan Bao, Wei Sun, Haidong Bao, Liang Bi, Wei Wen, Yanfeng Liu, Zhenglin Wang, Xunguo Yin, Yunqing Bai, Xiang Hu

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 2/2010

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Abstract

Objective

In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of rectal cancer patients.

Methods

Study participants were identified from a prospective cohort of patients with rectal cancer in Dalian of China (n = 123).

Results

The median baseline N/L ratio was 2.41 ± 2.206 (range, 0.76–20.45). Our results revealed that the N/L ratio was significantly associated with tumor size (P = 0.003) and level of cancer antigen 125 (P = 0.027). A multivariate Cox model established a significant relationship between the N/L ratio and survival (adjusted hazard ratio, 2.615; 95% confidence interval, 1.152–5.933; P = 0.021).

Conclusions

These results suggest that the N/L ratio is an independent prognostic factor in rectal cancer, and the N/L ratio may serve as a clinically accessible and useful biomarker for patient survival.

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Titel: The Baseline Ratio of Neutrophils to Lymphocytes is Associated with Patient Prognosis in Rectal Carcinoma
verfasst von: Huanran Liu
Ge Liu
Quan Bao
Wei Sun
Haidong Bao
Liang Bi
Wei Wen
Yanfeng Liu
Zhenglin Wang
Xunguo Yin
Yunqing Bai
Xiang Hu
Publikationsdatum: 01.06.2010
Verlag: Springer US
Erschienen in: Journal of Gastrointestinal Cancer / Ausgabe 2/2010
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-009-9125-4

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The Baseline Ratio of Neutrophils to Lymphocytes is Associated with Patient Prognosis in Rectal Carcinoma

Abstract

Objective

Methods

Results

Conclusions

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Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie