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01.12.2015 | Original Research

Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

verfasst von: Meysam Moghbeli, Mohammad Mahdi Forghanifard, Ali Sadrizadeh, Hooman Mosannen Mozaffari, Ebrahim Golmakani, Mohammad Reza Abbaszadegan

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 4/2015

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Abstract

Purpose

Developmental pathways such as Wnt and Notch are involved in different cellular functions from the cell cycle regulation to self-renewal. Therefore, aberrations in these pathways may cause tumorigenesis. Msi1 has a critical regulatory role for the Wnt and Notch pathways. In the present study, we have assessed the probable correlation between the Msi1 and MAML1 in esophageal squamous cell carcinoma (ESCC) progression and metastasis.

Methods

Levels of Msi1 and MAML1 mRNA expression in 51 ESCC patients were compared to the normal tissues using real-time polymerase chain reaction (PCR).

Results

Nine out of 51 (17.6 %) cases had Msi1/MAML1 overexpression, and there was a significant correlation between such overexpressed cases and tumor location (p = 0.013).

Conclusions

We showed that there is not any direct correlation and feedback between the Msi1 and MAML1 in ESCC patients.

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Titel: Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma
verfasst von: Meysam Moghbeli
Mohammad Mahdi Forghanifard
Ali Sadrizadeh
Hooman Mosannen Mozaffari
Ebrahim Golmakani
Mohammad Reza Abbaszadegan
Publikationsdatum: 01.12.2015
Verlag: Springer US
Erschienen in: Journal of Gastrointestinal Cancer / Ausgabe 4/2015
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-015-9753-9

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Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

Abstract

Purpose

Methods

Results

Conclusions

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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