Erschienen in:
01.06.2012 | Case Report
Does Kaposi’s sarcoma predict multicentric Castleman disease in the presence of generalized lymphadenopathy?
verfasst von:
Homam Alkaied, Kassem Harris, Dany Elsayegh, Inga Khachaturova, Michael Awasum, Seema Varma
Erschienen in:
Medical Oncology
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Ausgabe 2/2012
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Abstract
Multisystemic Castleman disease (MCD) can be associated with HHV8 infection, which involves the mantle zone of follicles. This condition results in an increase number of HHV8-positive (HHV8+) plasmablasts that multiply and amalgamate to form plasmablastic B-cell lymphoma. All previously reported cases of HIV-positive patients with MCD were coinfected with HHV8. Twelve cases of HIV− MCD that are HHV8+ were encountered in the literature, three of them developed lymphoma, and none of those cases were reported to have Kaposi’s sarcoma (KS). We report a unique case of HIV-negative elderly woman with preexisting KS that presented to the hospital with recurring nausea, vomiting, and fever, assessment revealed diffuse lymphadenopathy. Axillary lymph node biopsy showed HHV8+ MCD with foci of microlymphoma. Despite the treatment with high-dose steroids, she developed multisystem failure that lead to her death.