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Erschienen in: Medical Oncology 2/2012

01.06.2012 | Case Report

Does Kaposi’s sarcoma predict multicentric Castleman disease in the presence of generalized lymphadenopathy?

verfasst von: Homam Alkaied, Kassem Harris, Dany Elsayegh, Inga Khachaturova, Michael Awasum, Seema Varma

Erschienen in: Medical Oncology | Ausgabe 2/2012

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Abstract

Multisystemic Castleman disease (MCD) can be associated with HHV8 infection, which involves the mantle zone of follicles. This condition results in an increase number of HHV8-positive (HHV8+) plasmablasts that multiply and amalgamate to form plasmablastic B-cell lymphoma. All previously reported cases of HIV-positive patients with MCD were coinfected with HHV8. Twelve cases of HIV− MCD that are HHV8+ were encountered in the literature, three of them developed lymphoma, and none of those cases were reported to have Kaposi’s sarcoma (KS). We report a unique case of HIV-negative elderly woman with preexisting KS that presented to the hospital with recurring nausea, vomiting, and fever, assessment revealed diffuse lymphadenopathy. Axillary lymph node biopsy showed HHV8+ MCD with foci of microlymphoma. Despite the treatment with high-dose steroids, she developed multisystem failure that lead to her death.
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Metadaten
Titel
Does Kaposi’s sarcoma predict multicentric Castleman disease in the presence of generalized lymphadenopathy?
verfasst von
Homam Alkaied
Kassem Harris
Dany Elsayegh
Inga Khachaturova
Michael Awasum
Seema Varma
Publikationsdatum
01.06.2012
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 2/2012
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-011-9886-z

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