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Erschienen in: Medical Oncology 2/2012

01.06.2012 | Case Report

Cowden syndrome: a major indication for extensive cancer surveillance

verfasst von: Seda Tutluer, Mine Durusu Tanriover, Gulay Sain Guven

Erschienen in: Medical Oncology | Ausgabe 2/2012

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Abstract

Cowden syndrome (CS) or multiple hamartoma syndrome is a rare genetic disorder related to increased cellular proliferation of ectodermal, mesodermal, and endodermal tissues. It is characterized by multiple hamartomas and malignant neoplasms. Cancers of the breast, thyroid, endometrium, and skin are the most prevalent ones. Although close surveillance for cancer is required, many cases are undiagnosed or diagnosis comes at a late stage, partly due to the variable phenotype of the disease. Detection of multiple skin lesions of different characteristic in a patient with other local and systemic pathologies prompts further evaluation for CS. A case of CS, whose diagnosis is based upon skin lesions, alimentary tract polyposis, mental dullness, and history of spinal arteriovenous malformations, is discussed in this report.
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Metadaten
Titel
Cowden syndrome: a major indication for extensive cancer surveillance
verfasst von
Seda Tutluer
Mine Durusu Tanriover
Gulay Sain Guven
Publikationsdatum
01.06.2012
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 2/2012
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-011-9896-x

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