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Erschienen in: Medical Oncology 4/2012

01.12.2012 | Original Paper

PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker

verfasst von: Sayaka Yuzawa, Mitsunobu R. Kano, Takahiro Einama, Hiroshi Nishihara

Erschienen in: Medical Oncology | Ausgabe 4/2012

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Abstract

Pancreatic adenocarcinoma is a lethal disease that often develops a desmoplastic reaction in tumor stroma. In general, desmoplasia is thought to promote tumor growth. However, its molecular pathology and prognostic potential have not been fully investigated. Here, we investigate 26 cases of pancreatic ductal adenocarcinoma and examine the clinicopathological association between survival and expression levels of several molecular markers for stromal cells. These include alpha-smooth muscle actin (SMA) and platelet-derived growth factor (PDGF) receptor β (PDGFRβ). Both are markers of activated fibroblasts or pancreatic stellate cells (PSCs) that play an important role in desmoplasia. The staining patterns of both molecular markers were not uniform, so we categorized them into 3 grades (high, middle, and low) according to intensity. Interestingly, Kaplan–Meier analysis revealed that higher expression of PDGFRβ matched shorter prognosis (p = 0.0287, log-rank test) as well as lymphatic invasion and lymph node metastasis, whereas SMA did not (p = 0.6122). Our results suggest the prognostic potential of cancer stroma via PDGF-B signaling. Regulation of PDGF-B-associated signaling crosstalk between cancer cells and stroma cells, therefore, may indicate a possible therapeutic target for desmoplastic malignant tumors such as pancreatic adenocarcinoma.
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Metadaten
Titel
PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker
verfasst von
Sayaka Yuzawa
Mitsunobu R. Kano
Takahiro Einama
Hiroshi Nishihara
Publikationsdatum
01.12.2012
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 4/2012
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-012-0193-0

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