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Medical Oncology

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01.03.2015 | Original Paper

PinX1 inhibits cell proliferation, migration and invasion in glioma cells

verfasst von: Peng-Jin Mei, Yan-Su Chen, Ying Du, Jin Bai, Jun-Nian Zheng

Erschienen in: Medical Oncology | Ausgabe 3/2015

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Abstract

PinX1 induces apoptosis and suppresses cell proliferation in some cancer cells, and the expression of PinX1 is frequently decreased in some cancer and negatively associated with metastasis and prognosis. However, the precise roles of PinX1 in gliomas have not been studied. In this study, we found that PinX1 obviously reduced the gliomas cell proliferation through regulating the expressions of cell cycle-relative molecules to arrest cell at G1 phase and down-regulating the expression of component telomerase reverse transcriptase (hTERT in human), which is the hardcore of telomerase. Moreover, PinX1 could suppress the abilities of gliomas cell wound healing, migration and invasion via suppressing MMP-2 expression and increasing TIMP-2 expression. In conclusion, our results suggested that PinX1 may be a potential suppressive gene in the progression of gliomas.

Ostrom QT, et al. CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010. Neuro Oncol. 2013;15(Suppl 2):1–56.CrossRef

Goodenberger ML. RB Jenkins. Genetics of adult glioma. Cancer Genet. 2012;205(12):613–21.CrossRefPubMed

Urbanska K, et al. Glioblastoma multiforme - an overview. Contemp Oncol (Pozn). 2014;18(5):307–12.PubMedCentralPubMed

Mrugala MM. Advances and challenges in the treatment of glioblastoma: a clinician’s perspective. Discov Med. 2013;15(83):221–30.PubMed

Sorensen AG, et al. Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Res. 2012;72(2):402–7.PubMedCentralCrossRefPubMed

Specenier P. Bevacizumab in glioblastoma multiforme. Expert Rev Anticancer Ther. 2012;12(1):9–18.CrossRefPubMed

Karcher S, et al. Different angiogenic phenotypes in primary and secondary glioblastomas. Int J Cancer. 2006;118(9):2182–9.CrossRefPubMed

Zhou XZ, Lu KP. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell. 2001;107(3):347–59.CrossRefPubMed

Yoo JE, Park YN, Oh BK. PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. J Biol Chem. 2014;289(10):6886–98.PubMedCentralCrossRefPubMed

10.

Yonekawa T, Yang S, Counter CM. PinX1 localizes to telomeres and stabilizes TRF1 at mitosis. Mol Cell Biol. 2012;32(8):1387–95.PubMedCentralCrossRefPubMed

11.

Zhou XZ, et al. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J Clin Invest. 2011;121(4):1266–82.PubMedCentralCrossRefPubMed

12.

Kondo T, et al. Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. Oncogene. 2005;24(1):157–64.CrossRefPubMed

13.

Ma Y, et al. The correlation of genetic instability of PINX1 gene to clinico-pathological features of gastric cancer in the Chinese population. J Cancer Res Clin Oncol. 2009;135(3):431–7.CrossRefPubMed

14.

Shi R, et al. Reduced expression of PinX1 correlates to progressive features in patients with prostate cancer. Cancer Cell Int. 2014;14:46.PubMedCentralCrossRefPubMed

15.

Cai MY, et al. Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma. Cancer Sci. 2010;101(6):1543–9.CrossRefPubMed

16.

Zhang R, et al. PinX1 without the G-patch motif suppresses proliferation, induces senescence, but does not inhibit telomerase activity in colorectal cancer SW480 cells. Oncol Rep. 2014;32(1):286–92.PubMed

17.

Liu JY, et al. PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway. Mol Cancer. 2013;12(1):148.PubMedCentralCrossRefPubMed

18.

Bai J, et al. JWA regulates melanoma metastasis by integrin alphaVbeta3 signaling. Oncogene. 2010;29(8):1227–37.CrossRefPubMed

19.

Denicourt C, Dowdy SF. Cip/Kip proteins: more than just CDKs inhibitors. Genes Dev. 2004;18(8):851–5.CrossRefPubMed

20.

Zuo J, et al. Expression and mechanism of PinX1 and telomerase activity in the carcinogenesis of esophageal epithelial cells. Oncol Rep. 2013;30(4):1823–31.PubMed

21.

Chaudhary AK, et al. Matrix metalloproteinase and its drug targets therapy in solid and hematological malignancies: an overview. Mutat Res. 2013;753(1):7–23.CrossRefPubMed

22.

Libra M, et al. Uterine cervical carcinoma: role of matrix metalloproteinases (review). Int J Oncol. 2009;34(4):897–903.CrossRefPubMed

23.

Wan SM, et al. Silencing of the hPOT1 gene by RNA inference promotes apoptosis and inhibits proliferation and aggressive phenotype of gastric cancer cells, likely through up-regulating PinX1 expression. J Clin Pathol. 2011;64(12):1051–7.CrossRefPubMed

24.

Collins K. The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol. 2006;7(7):484–94.PubMedCentralCrossRefPubMed

25.

Zhang B, et al. Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation. Oncogene. 2012;31(1):1–12.CrossRefPubMed

26.

Nakada M, et al. Molecular targets of glioma invasion. Cell Mol Life Sci. 2007;64(4):458–78.CrossRefPubMed

27.

Cuddapah VA, et al. A neurocentric perspective on glioma invasion. Nat Rev Neurosci. 2014;15(7):455–65.CrossRefPubMed

28.

Nie E, et al. beta-Catenin is involved in Bex2 down-regulation induced glioma cell invasion/migration inhibition. Biochem Biophys Res Commun. 2014.

29.

Roomi MW, et al. Modulation of uPA, MMPs and their inhibitors by a novel nutrient mixture in human glioblastoma cell lines. Int J Oncol. 2014;45(2):887–94.PubMed

30.

Singh MK, et al. T11TS inhibits glioma angiogenesis by modulation of MMPs, TIMPs, with related integrin alphav and TGF-beta1 expressions. Tumour Biol. 2014;35(3):2231–46.CrossRefPubMed

Titel: PinX1 inhibits cell proliferation, migration and invasion in glioma cells
verfasst von: Peng-Jin Mei
Yan-Su Chen
Ying Du
Jin Bai
Jun-Nian Zheng
Publikationsdatum: 01.03.2015
Verlag: Springer US
Erschienen in: Medical Oncology / Ausgabe 3/2015
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-015-0545-7

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16.04.2024 | Maligne primäre ZNS-Tumoren | Nachrichten

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