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Neural Crest and Olfactory System: New Prospective

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Abstract

Sensory neurons in vertebrates are derived from two embryonic transient cell sources: neural crest (NC) and ectodermal placodes. The placodes are thickenings of ectodermal tissue that are responsible for the formation of cranial ganglia as well as complex sensory organs that include the lens, inner ear, and olfactory epithelium. The NC cells have been indicated to arise at the edges of the neural plate/dorsal neural tube, from both the neural plate and the epidermis in response to reciprocal interactions Moury and Jacobson (Dev Biol 141:243–253, 1990). NC cells migrate throughout the organism and give rise to a multitude of cell types that include melanocytes, cartilage and connective tissue of the head, components of the cranial nerves, the dorsal root ganglia, and Schwann cells. The embryonic definition of these two transient populations and their relative contribution to the formation of sensory organs has been investigated and debated for several decades (Basch and Bronner-Fraser, Adv Exp Med Biol 589:24–31, 2006; Basch et al., Nature 441:218–222, 2006) review (Baker and Bronner-Fraser, Dev Biol 232:1–61, 2001). Historically, all placodes have been described as exclusively derived from non-neural ectodermal progenitors. Recent genetic fate-mapping studies suggested a NC contribution to the olfactory placodes (OP) as well as the otic (auditory) placodes in rodents (Murdoch and Roskams, J Neurosci Off J Soc Neurosci 28:4271–4282, 2008; Murdoch et al., J Neurosci 30:9523–9532, 2010; Forni et al., J Neurosci Off J Soc Neurosci 31:6915–6927, 2011b; Freyer et al., Development 138:5403–5414, 2011; Katoh et al., Mol Brain 4:34, 2011). This review analyzes and discusses some recent developmental studies on the OP, placodal derivatives, and olfactory system.

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Acknowledgments

The authors thank Dr. David H. Gutmann (Washington University School of Medicine, St Louis, MO, USA) for sharing the BLBPCreIRESLacZ mouse line.

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  1. Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Rm. 3A-1012, Bethesda, MD, 20892-3703, USA

    Paolo E. Forni & Susan Wray

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  1. Paolo E. Forni
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  2. Susan Wray
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Correspondence to Susan Wray.

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This work was supported by the Intramural Research Program of the National Institutes of Health, National Institute of Neurological Disorders and Stroke.

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Forni, P.E., Wray, S. Neural Crest and Olfactory System: New Prospective. Mol Neurobiol 46, 349–360 (2012). https://doi.org/10.1007/s12035-012-8286-5

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