Abstract
Stress leads to detrimental effects on brain functions and results in various diseases. Recent studies highlight the involvement of glutamatergic transmission in pathogenesis of depressive behaviors and fears. Acute stress generates different impacts on the excitatory transmission compared to chronic stress. Different neuromodulators and epigenetic factors also participate in the alteration of synaptic transmission and the regulation of synaptic plasticity. Restoration of the glutamatergic transmission in stress-affected brain areas therefore provides novel directions of therapeutic interventions against stress.
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Acknowledgments
TY is supported by “Hundred Talents Program” and “Qing Lan Project” of Nanjing Normal University. GH received grants from Science Philosophy Betterment Society (Registered British Virgin Islands).
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Yuan, TF., Hou, G. The Effects of Stress on Glutamatergic Transmission in the Brain. Mol Neurobiol 51, 1139–1143 (2015). https://doi.org/10.1007/s12035-014-8783-9
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DOI: https://doi.org/10.1007/s12035-014-8783-9