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Endoplasmic Reticulum Stress: Relevance and Therapeutics in Central Nervous System Diseases

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Abstract

Endoplasmic reticulum (ER) stress plays an important role in a range of neurological disorders, such as neurodegenation diseases, cerebral ischemia, spinal cord injury, sclerosis, and diabetic neuropathy. Protein misfolding and accumulation in the ER lumen initiate unfolded protein response in energy-starved neurons which are relevant to toxic effects. In neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, ER dysfunction is well recognized, but the mechanisms remain unclear. In stroke and ischemia, spinal cord injury, and amyotrophic lateral sclerosis, chronic activation of ER stress is considered as main pathogeny which causes neuronal disorders. By targeting components of these ER signaling responses, to explore clinical treatment strategies or new drugs in CNS neurological diseases might become possible and valuable in the future.

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Acknowledgments

This work was supported by Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents (to J.X.), National Natural Science Funding of China (81372112, 81200958, 81200010, 81302775), Zhejiang Provincial Project of Protein Medicine Key Group (2010R50042).

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The authors declare no conflict of interest.

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  1. School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, 325035, China

    Hong-Yu Zhang, Zhou-guang Wang, Fen-Zan Wu, Li Lin, Xiaohua Tan, Li-Bing Ye & Jian Xiao

  2. Translation Medicine Research Center, Lishui People’s Hospital, Wenzhou Medical University, Lishui, 323000, China

    Xiang-Hong Lu

  3. School of Basic Medical Sciences, Institute of Hypoxia Research, Wenzhou Medical University, Wenzhou, 325035, China

    Xiao-Xia Kong

  4. Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Jilin University, Changchun, 130012, China

    Zhou-guang Wang

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Zhang, HY., Wang, Zg., Lu, XH. et al. Endoplasmic Reticulum Stress: Relevance and Therapeutics in Central Nervous System Diseases. Mol Neurobiol 51, 1343–1352 (2015). https://doi.org/10.1007/s12035-014-8813-7

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