Abstract
Cervical cancer is the second most common life-threatening cancer among women worldwide, with incidence rates ranging from 4.8 per 100,000 in the Middle East to 44.3 per 100,000 in East Africa. Human papillomavirus (HPV) infection, especially HPV-16 and HPV-18, plays a major role in the etiology of cervical cancer, but HPV alone is not sufficient to induce cancer. We propose that squamous cell cervical cancer is caused by an interaction of oncogenic viruses and cervical tar exposures. Cervical tar exposures occur from cigarette smoking, use of tar-based vaginal douche products (TBD), and long years of inhaling smoke from wood- and coal-burning stoves in poorly ventilated kitchens.
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References
Anonymous 1995 Human papillomaviruses; IARC Monogr. Eval. Carcinog. Risks Human 64 1–379
Anonymous 2004 Tobacco smoke and involuntary smoking; IARC Monogr. Eval. Carcinog. Risks Humans 83 1–1438
Bosch F X, Manos M M, Munoz N, Sherman M, Jansen A M, Peto J, Schiffman M H, Moreno V, et al. 1995 Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study in cervical cancer (BSCC) Study Group; J. Natl. Cancer Inst. 87 796–802
Castle P E, Wacholder S, Lorincz A T, Scott D R, Sherman M E, Glass A G, Rush B B, Schussler J E, et al. 2002 A prospective study of high-grade cervical neoplasia risk among human papillomavirus-infected women; J. Natl. Cancer Inst. 94 1406–1414
Ferrera A, Velema J, Figueroa M, Bulnes R, Toro L A, Claros J M, de Barahona O and Melchers W J 2000 Co-factors related to the causal relationship between HPV and invasive cervical cancer in Honduras; Int. J. Epidemiol. 29 817–825
Haverkos H W 2005 Multifactorial etiology of cervical: a hypothesis; Medscape Gen. Med. 7 57 posted 11/30/2005
Haverkos H W, Boring D, Kruhlak N and Matthews E J 2008 Carcinogenic potential of tar-based vaginal douche products and cervical cancer; in American Association for Cancer Research Annual Meeting 2008, April 12–16, 2008, San Diego, California, Abstract #5570
Haverkos H W, Soon G, Steckley S L, and Pickworth W 2003 Cigarette smoking and cervical cancer: Part 1: a metaanalysis; Biomed. Pharmacother. 57 67–77
International Collaboration of Epidemiological Studies of Cervical Cancer 2006 Carcinoma of the cervix and tobacco smoking: collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies; Int. J. Cancer 118 1481–1495
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, and Thun M J 2008 Cancer statistics, 2008; CA Cancer J. Clin. 58 71–96
Lombard H L and Potter E A 1950 Epidemiologic aspects of cancer of the cervix: II. Hereditary and environmental factors; Cancer 3 960–968
Munoz N, Bosch F X, de Sanjose S, Herrero R, Castellsague X, Shah K V, Snijders P J, Meijer C J, et al. 2003 Epidemiologic classification of human papillomavirus types associated with cervical cancer. International Agency for Research on Cancer Multicenter Cervical Cancer Study Group; New Engl. J. Med. 348 518–527
Prokopczyk B, Cox J E, Hoffmann D and Waggoner S E 1997 Identification of tobacco-specific carcinogen in the cervical mucus of smokers and nonsmokers; J. Natl. Cancer Inst. 89 868–873
Prokopczyk B, Sinha I, Trushin N, Freeman W M and El-Bayoumy K 2008 Gene expression profiles of HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; Chem. Biol. Interact. Nov 6. [Epub ahead of print]
Rogers S and Rous P 1951 Joint action of a chemical carcinogen and a neoplastic virus to induce cancer in rabbits: results of exposing epidermal cells to a carcinogenic hydrocarbon at time of infection with the Shope papilloma virus; J. Exp. Med. 93 459–486
Rotkin I D 1967 Epidemiology of cancer of the cervix: 3: Sexual characteristics of a cervical cancer population; Am. J. Public Health Nations Health 57 815–829
Smith F R 1931 Etiologic factors in carcinoma of the cervix; Am. J. Obstet. Gynecol. 21 18–25
Steckley S L, Pickworth W B and Haverkos H W 2003 Cigarette smoking and cervical cancer: Part II: a geographic variability study; Biomed. Pharmacother. 57 78–83
Velema J P, Ferrera A, Figueroa M, Bulnes R, Toro L A, de Barahona O, Claros J M, and Melchers W J G 2002 Burning wood in the kitchen increases the risk of cervical neoplasia in HPV-infected women in Honduras;. Int. J. Cancer 97 536–541
Walboomers J M, Jacobs M V, Manos M M, Bosch F X, Kummer J A, Shah K V, Snijders P J, Peto J, et al. 1999 Human papillomavirus is a necessary cause of invasive cervical cancer worldwide; J. Pathol. 189 12–19
Winkelstein W Jr, Sacks S T, Ernster V L, and Selvin S 1977 Corrlations of incidence rates for selected cancers in the nine areas of the Third National Cancer Survey; Am. J. Epidemiol 105 407–409
Winkelstein W Jr 1977 Smoking and cancer of the uterine cervix: hypothesis; Am. J. Epidemiol. 106 257
World Health Organization 2006 Fuel for life: household energy and health (Geneva, Switzerland) Available at http://www.who.int/indoorair/pulblications/fuelforlife/en/index.html
zur Hausen H 1989 Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers; Cancer Res. 49 4677–4681
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Bennett, C., Kuhn, A.E. & Haverkos, H.W. Human papillomavirus and tar hypothesis for squamous cell cervical cancer. J Biosci 35, 331–337 (2010). https://doi.org/10.1007/s12038-010-0038-y
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DOI: https://doi.org/10.1007/s12038-010-0038-y