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Hepatology International
Erschienen in: Hepatology International 5/2019

31.08.2019 | Review Article

Radiomics in hepatocellular carcinoma: a quantitative review

verfasst von: Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix

Erschienen in: Hepatology International | Ausgabe 5/2019

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Abstract

Radiomics is an emerging field which extracts quantitative radiology data from medical images and explores their correlation with clinical outcomes in a non-invasive manner. This review aims to assess whether radiomics is a useful and reproducible method for clinical management of hepatocellular carcinoma (HCC) by reviewing the strengths and weaknesses of current radiomics literature pertaining specifically to HCC. From an initial set of 48 articles recovered through database searches, 23 articles were retained to be included in this review after full screening. Among these 23 studies, 7 used a radiomics approach in magnetic resonance imaging (MRI). Only two studies applied radiomics to positron emission tomography–computed tomography (PET–CT). In the remaining 14 articles, a radiomics analysis was performed on computed tomography (CT). Eight studies dealt with the relationship between biological signatures and imaging findings, and can be classified as radiogenomic studies. For each study included in our review, we computed a Radiomics Quality Score (RQS) as proposed by Lambin et al. We found that the RQS (mean ± standard deviation) was 8.35 ± 5.38 (out of a possible maximum value of 36). Although these scores are fairly low, and radiomics has not yet reached clinical utility in HCC, it is important to underscore the fact that these early studies pave the way for the radiomics field with a focus on HCC. Radiomics is still a very young field, and is far from being mature, but it remains a very promising technology for the future for developing adequate personalized treatment as a non-invasive approach, for complementing or replacing tumor biopsies, as well as for developing novel prognostic biomarkers in HCC patients.
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Metadaten
Titel
Radiomics in hepatocellular carcinoma: a quantitative review
verfasst von
Taiga Wakabayashi
Farid Ouhmich
Cristians Gonzalez-Cabrera
Emanuele Felli
Antonio Saviano
Vincent Agnus
Peter Savadjiev
Thomas F. Baumert
Patrick Pessaux
Jacques Marescaux
Benoit Gallix
Publikationsdatum
31.08.2019
Verlag
Springer India
Erschienen in
Hepatology International / Ausgabe 5/2019
Print ISSN: 1936-0533
Elektronische ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-019-09973-0

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