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Erschienen in: Clinical and Translational Oncology 10/2013

01.10.2013 | Research Article

Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and overall survival in patients with metastatic breast cancer: reargument of such contentious therapeutic preferences

verfasst von: Jun Ren, Lijun Di, Guohong Song, Jing Yu, Jun Jia, Yuling Zhu, Ying Yan, Hanfang Jiang, Xu Liang, Li Che, Jie Zhang, Fengling Wan, Xiaoli Wang, Xinna Zhou, Herbert Kim Lyerly

Erschienen in: Clinical and Translational Oncology | Ausgabe 10/2013

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Abstract

Background

We hypothesized that combination of dendritic cell (DC) with autologous cytokine-induced killer (CIK) immunotherapy in setting of high-dose chemotherapy (HDC) would be effective for selected metastatic breast cancer (MBC) patients.

Patients and methods

Our previous work showed thiotepa could eradicate breast cancer stem cells. From 2004 to 2009, 79 patients received standard dose chemotherapy (SDC) of 75 mg/m2 docetaxel and 75 mg/m2 thiotepa versus 87 patients of HDC + DC/CIK: 120 mg/m2 docetaxel to mobilize peripheral CD34+ progenitor cells, a sequence of HDC (120 mg/m2 docetaxel, plus 175 mg/m2 thiotepa) + DC/CIK, with or without 400 mg/m2 carboplatin depending upon bone marrow function. The endpoints were response rates (RR), progression-free survival (PFS), and overall survival (OS).

Results

Compared with SDC, PFS and OS were improved in HDC + DC/CIK (median PFS 10.2 vs. 3.7 months, P < 0.001; median OS 33.1 vs. 15.2 months, P < 0.001). Patients of pre-menopausal, HDC as first-line treatment after metastasis, or with visceral metastasis showed prolonged PFS and OS. SDC group also achieved the similar response as previous reports.

Conclusion

Our study demonstrated the novel combination of HDC with DC/CIK to be an effective choice for the selected MBC population, in which choosing appropriate chemo regimens played important roles, and also specific HDC regimen plus DC/CIK immunotherapy showed the clinical benefits compared with chemotherapy alone.
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Metadaten
Titel
Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and overall survival in patients with metastatic breast cancer: reargument of such contentious therapeutic preferences
verfasst von
Jun Ren
Lijun Di
Guohong Song
Jing Yu
Jun Jia
Yuling Zhu
Ying Yan
Hanfang Jiang
Xu Liang
Li Che
Jie Zhang
Fengling Wan
Xiaoli Wang
Xinna Zhou
Herbert Kim Lyerly
Publikationsdatum
01.10.2013
Verlag
Springer Milan
Erschienen in
Clinical and Translational Oncology / Ausgabe 10/2013
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-013-1001-9

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